SGPP1 (sphingosine-1-phosphate phosphatase 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 81537
• Gene name: Sphingosine-1-phosphate phosphatase 1
• Gene symbol: SGPP1
• Synonyms (NCBI Gene): SPP-1, SPPase1
• Chromosome: 14
• Chromosome location: 14q23.2
• Summary: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 1085935

miRNA Show/Hide all (212)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021888	hsa-miR-128-3p	Microarray	17612493
MIRT024760	hsa-miR-215-5p	Microarray	19074876
MIRT025318	hsa-miR-34a-5p	Sequencing	20371350
MIRT026208	hsa-miR-192-5p	Microarray	19074876
MIRT726599	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726597	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726598	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1343734	hsa-miR-101	CLIP-seq
MIRT1343735	hsa-miR-1179	CLIP-seq
MIRT1343736	hsa-miR-124	CLIP-seq
MIRT1343737	hsa-miR-1250	CLIP-seq
MIRT1343738	hsa-miR-1261	CLIP-seq
MIRT1343739	hsa-miR-128	CLIP-seq
MIRT1343740	hsa-miR-1298	CLIP-seq
MIRT1343741	hsa-miR-1323	CLIP-seq
MIRT1343742	hsa-miR-133a	CLIP-seq
MIRT1343743	hsa-miR-133b	CLIP-seq
MIRT1343744	hsa-miR-142-5p	CLIP-seq
MIRT1343745	hsa-miR-144	CLIP-seq
MIRT1343746	hsa-miR-191	CLIP-seq
MIRT1343747	hsa-miR-22	CLIP-seq
MIRT1343748	hsa-miR-25	CLIP-seq
MIRT1343749	hsa-miR-2681	CLIP-seq
MIRT1343750	hsa-miR-2682	CLIP-seq
MIRT1343751	hsa-miR-27a	CLIP-seq
MIRT1343752	hsa-miR-27b	CLIP-seq
MIRT1343753	hsa-miR-3163	CLIP-seq
MIRT1343754	hsa-miR-32	CLIP-seq
MIRT1343755	hsa-miR-323-3p	CLIP-seq
MIRT1343756	hsa-miR-325	CLIP-seq
MIRT1343757	hsa-miR-337-3p	CLIP-seq
MIRT1343758	hsa-miR-345	CLIP-seq
MIRT1343759	hsa-miR-34a	CLIP-seq
MIRT1343760	hsa-miR-34c-5p	CLIP-seq
MIRT1343761	hsa-miR-3613-3p	CLIP-seq
MIRT1343762	hsa-miR-363	CLIP-seq
MIRT1343763	hsa-miR-3647-3p	CLIP-seq
MIRT1343764	hsa-miR-3662	CLIP-seq
MIRT1343765	hsa-miR-3663-5p	CLIP-seq
MIRT1343766	hsa-miR-367	CLIP-seq
MIRT1343767	hsa-miR-3692	CLIP-seq
MIRT1343768	hsa-miR-369-3p	CLIP-seq
MIRT1343769	hsa-miR-370	CLIP-seq
MIRT1343770	hsa-miR-374a	CLIP-seq
MIRT1343771	hsa-miR-374b	CLIP-seq
MIRT1343772	hsa-miR-374c	CLIP-seq
MIRT1343773	hsa-miR-3913-3p	CLIP-seq
MIRT1343774	hsa-miR-421	CLIP-seq
MIRT1343775	hsa-miR-4264	CLIP-seq
MIRT1343776	hsa-miR-4268	CLIP-seq
MIRT1343777	hsa-miR-4275	CLIP-seq
MIRT1343778	hsa-miR-4282	CLIP-seq
MIRT1343779	hsa-miR-4325	CLIP-seq
MIRT1343780	hsa-miR-4328	CLIP-seq
MIRT1343781	hsa-miR-4436b-5p	CLIP-seq
MIRT1343782	hsa-miR-4448	CLIP-seq
MIRT1343783	hsa-miR-4496	CLIP-seq
MIRT1343784	hsa-miR-449a	CLIP-seq
MIRT1343785	hsa-miR-449b	CLIP-seq
MIRT1343786	hsa-miR-449c	CLIP-seq
MIRT1343787	hsa-miR-4514	CLIP-seq
MIRT1343788	hsa-miR-4522	CLIP-seq
MIRT1343789	hsa-miR-4643	CLIP-seq
MIRT1343790	hsa-miR-466	CLIP-seq
MIRT1343791	hsa-miR-4666-5p	CLIP-seq
MIRT1343792	hsa-miR-4668-3p	CLIP-seq
MIRT1343793	hsa-miR-4692	CLIP-seq
MIRT1343794	hsa-miR-4694-3p	CLIP-seq
MIRT1343795	hsa-miR-4716-5p	CLIP-seq
MIRT1343796	hsa-miR-4766-3p	CLIP-seq
MIRT1343797	hsa-miR-4789-3p	CLIP-seq
MIRT1343798	hsa-miR-4797-3p	CLIP-seq
MIRT1343799	hsa-miR-4799-5p	CLIP-seq
MIRT1343800	hsa-miR-485-3p	CLIP-seq
MIRT1343801	hsa-miR-487a	CLIP-seq
MIRT1343802	hsa-miR-488	CLIP-seq
MIRT1343803	hsa-miR-489	CLIP-seq
MIRT1343804	hsa-miR-490-5p	CLIP-seq
MIRT1343805	hsa-miR-499-3p	CLIP-seq
MIRT1343806	hsa-miR-499a-3p	CLIP-seq
MIRT1343807	hsa-miR-506	CLIP-seq
MIRT1343808	hsa-miR-522	CLIP-seq
MIRT1343809	hsa-miR-543	CLIP-seq
MIRT1343810	hsa-miR-548ac	CLIP-seq
MIRT1343811	hsa-miR-548ae	CLIP-seq
MIRT1343812	hsa-miR-548ag	CLIP-seq
MIRT1343813	hsa-miR-548ai	CLIP-seq
MIRT1343814	hsa-miR-548aj	CLIP-seq
MIRT1343815	hsa-miR-548am	CLIP-seq
MIRT1343816	hsa-miR-548an	CLIP-seq
MIRT1343817	hsa-miR-548c-3p	CLIP-seq
MIRT1343818	hsa-miR-548d-3p	CLIP-seq
MIRT1343819	hsa-miR-548m	CLIP-seq
MIRT1343820	hsa-miR-548n	CLIP-seq
MIRT1343821	hsa-miR-548o	CLIP-seq
MIRT1343822	hsa-miR-548t	CLIP-seq
MIRT1343823	hsa-miR-548x	CLIP-seq
MIRT1343824	hsa-miR-548z	CLIP-seq
MIRT1343825	hsa-miR-561	CLIP-seq
MIRT1343826	hsa-miR-569	CLIP-seq
MIRT1343827	hsa-miR-577	CLIP-seq
MIRT1343828	hsa-miR-586	CLIP-seq
MIRT1343829	hsa-miR-601	CLIP-seq
MIRT1343830	hsa-miR-605	CLIP-seq
MIRT1343831	hsa-miR-628-3p	CLIP-seq
MIRT1343832	hsa-miR-634	CLIP-seq
MIRT1343833	hsa-miR-655	CLIP-seq
MIRT1343834	hsa-miR-885-5p	CLIP-seq
MIRT1343835	hsa-miR-92a	CLIP-seq
MIRT1343836	hsa-miR-92b	CLIP-seq
MIRT1343736	hsa-miR-124	CLIP-seq
MIRT1343746	hsa-miR-191	CLIP-seq
MIRT1553640	hsa-miR-451b	CLIP-seq
MIRT1343796	hsa-miR-4766-3p	CLIP-seq
MIRT1343807	hsa-miR-506	CLIP-seq
MIRT1343816	hsa-miR-548an	CLIP-seq
MIRT1343734	hsa-miR-101	CLIP-seq
MIRT1343735	hsa-miR-1179	CLIP-seq
MIRT1343736	hsa-miR-124	CLIP-seq
MIRT2101602	hsa-miR-1273e	CLIP-seq
MIRT1343739	hsa-miR-128	CLIP-seq
MIRT1343740	hsa-miR-1298	CLIP-seq
MIRT1343741	hsa-miR-1323	CLIP-seq
MIRT1343744	hsa-miR-142-5p	CLIP-seq
MIRT1343745	hsa-miR-144	CLIP-seq
MIRT1343746	hsa-miR-191	CLIP-seq
MIRT2101603	hsa-miR-19a	CLIP-seq
MIRT2101604	hsa-miR-19b	CLIP-seq
MIRT1343747	hsa-miR-22	CLIP-seq
MIRT1343751	hsa-miR-27a	CLIP-seq
MIRT1343752	hsa-miR-27b	CLIP-seq
MIRT2101605	hsa-miR-3115	CLIP-seq
MIRT2101606	hsa-miR-3136-3p	CLIP-seq
MIRT2101607	hsa-miR-3140-5p	CLIP-seq
MIRT2101608	hsa-miR-3153	CLIP-seq
MIRT1343753	hsa-miR-3163	CLIP-seq
MIRT1343758	hsa-miR-345	CLIP-seq
MIRT2101609	hsa-miR-3620	CLIP-seq
MIRT1343764	hsa-miR-3662	CLIP-seq
MIRT2101610	hsa-miR-3671	CLIP-seq
MIRT1343767	hsa-miR-3692	CLIP-seq
MIRT1343773	hsa-miR-3913-3p	CLIP-seq
MIRT2101611	hsa-miR-3942-5p	CLIP-seq
MIRT1343778	hsa-miR-4282	CLIP-seq
MIRT1553640	hsa-miR-451b	CLIP-seq
MIRT1343788	hsa-miR-4522	CLIP-seq
MIRT1343789	hsa-miR-4643	CLIP-seq
MIRT1343790	hsa-miR-466	CLIP-seq
MIRT2101612	hsa-miR-4668-5p	CLIP-seq
MIRT2101613	hsa-miR-4680-3p	CLIP-seq
MIRT2101614	hsa-miR-4703-5p	CLIP-seq
MIRT2101615	hsa-miR-4732-3p	CLIP-seq
MIRT2101616	hsa-miR-4747-3p	CLIP-seq
MIRT1343796	hsa-miR-4766-3p	CLIP-seq
MIRT2101617	hsa-miR-4775	CLIP-seq
MIRT1343797	hsa-miR-4789-3p	CLIP-seq
MIRT1343803	hsa-miR-489	CLIP-seq
MIRT1343805	hsa-miR-499-3p	CLIP-seq
MIRT1343806	hsa-miR-499a-3p	CLIP-seq
MIRT1343807	hsa-miR-506	CLIP-seq
MIRT1343816	hsa-miR-548an	CLIP-seq
MIRT1343821	hsa-miR-548o	CLIP-seq
MIRT2101618	hsa-miR-553	CLIP-seq
MIRT1343825	hsa-miR-561	CLIP-seq
MIRT2101619	hsa-miR-607	CLIP-seq
MIRT2101620	hsa-miR-944	CLIP-seq
MIRT1343734	hsa-miR-101	CLIP-seq
MIRT1343735	hsa-miR-1179	CLIP-seq
MIRT1343736	hsa-miR-124	CLIP-seq
MIRT1343739	hsa-miR-128	CLIP-seq
MIRT1343746	hsa-miR-191	CLIP-seq
MIRT1343750	hsa-miR-2682	CLIP-seq
MIRT1343751	hsa-miR-27a	CLIP-seq
MIRT1343752	hsa-miR-27b	CLIP-seq
MIRT1343753	hsa-miR-3163	CLIP-seq
MIRT1343773	hsa-miR-3913-3p	CLIP-seq
MIRT2101611	hsa-miR-3942-5p	CLIP-seq
MIRT1343778	hsa-miR-4282	CLIP-seq
MIRT2326024	hsa-miR-4464	CLIP-seq
MIRT1343786	hsa-miR-449c	CLIP-seq
MIRT1343787	hsa-miR-4514	CLIP-seq
MIRT1553640	hsa-miR-451b	CLIP-seq
MIRT1343789	hsa-miR-4643	CLIP-seq
MIRT1343790	hsa-miR-466	CLIP-seq
MIRT1343793	hsa-miR-4692	CLIP-seq
MIRT2101614	hsa-miR-4703-5p	CLIP-seq
MIRT2326025	hsa-miR-4748	CLIP-seq
MIRT1343796	hsa-miR-4766-3p	CLIP-seq
MIRT2101617	hsa-miR-4775	CLIP-seq
MIRT1343797	hsa-miR-4789-3p	CLIP-seq
MIRT1343803	hsa-miR-489	CLIP-seq
MIRT1343807	hsa-miR-506	CLIP-seq
MIRT1343810	hsa-miR-548ac	CLIP-seq
MIRT1343811	hsa-miR-548ae	CLIP-seq
MIRT1343814	hsa-miR-548aj	CLIP-seq
MIRT1343815	hsa-miR-548am	CLIP-seq
MIRT1343816	hsa-miR-548an	CLIP-seq
MIRT1343818	hsa-miR-548d-3p	CLIP-seq
MIRT1343823	hsa-miR-548x	CLIP-seq
MIRT1343824	hsa-miR-548z	CLIP-seq
MIRT2101620	hsa-miR-944	CLIP-seq
MIRT2440287	hsa-miR-4667-3p	CLIP-seq
MIRT1343801	hsa-miR-487a	CLIP-seq
MIRT2621689	hsa-miR-4710	CLIP-seq
MIRT2621690	hsa-miR-4792	CLIP-seq
MIRT2621691	hsa-miR-539	CLIP-seq
MIRT1343825	hsa-miR-561	CLIP-seq
MIRT1343744	hsa-miR-142-5p	CLIP-seq
MIRT2621689	hsa-miR-4710	CLIP-seq
MIRT2621690	hsa-miR-4792	CLIP-seq
MIRT2621691	hsa-miR-539	CLIP-seq
MIRT1343825	hsa-miR-561	CLIP-seq

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006665	Process	Sphingolipid metabolic process	IEA
GO:0006668	Process	Sphinganine-1-phosphate metabolic process	IEA
GO:0006670	Process	Sphingosine metabolic process	IBA
GO:0006670	Process	Sphingosine metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030149	Process	Sphingolipid catabolic process	IEA
GO:0030149	Process	Sphingolipid catabolic process	TAS
GO:0035621	Process	ER to Golgi ceramide transport	IMP	16782891
GO:0042392	Function	Sphingosine-1-phosphate phosphatase activity	IBA
GO:0042392	Function	Sphingosine-1-phosphate phosphatase activity	IDA	16782891
GO:0042392	Function	Sphingosine-1-phosphate phosphatase activity	IEA
GO:0042392	Function	Sphingosine-1-phosphate phosphatase activity	TAS
GO:0045616	Process	Regulation of keratinocyte differentiation	IEA
GO:0045616	Process	Regulation of keratinocyte differentiation	ISS
GO:0045682	Process	Regulation of epidermis development	IEA
GO:0045682	Process	Regulation of epidermis development	ISS
GO:0046839	Process	Phospholipid dephosphorylation	IBA
GO:0070780	Function	Dihydrosphingosine-1-phosphate phosphatase activity	IEA
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IEA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IEA

Other IDs

• MIM: 612826
• HGNC: 17720
• e!Ensembl: ENSG00000126821

Protein

• UniProt ID: Q9BX95
• Protein name: Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)
• Protein function: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed f
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01569	PAP2	160 → 280	PAP2 superfamily	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous, with the strongest level in placenta and kidney. {ECO:0000269|PubMed:12815058}.
• Sequence:

  MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEKAEAPLAGDPRLRGRQP
  GAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASPRRAGALRRNSLTGEEGQL
  ARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDI
  IRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQYPLIYGLILIPC
  WCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDLIDNFNQTHKYAPFIIIGLHL
  ALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHVTYNMGLVLDPSLDTLPLAGPPITVT
  LFGKAILRILIGMVFVLIIRDVMKKITIPLACKIFNIPCDDIRKARQHMEVELPYRYITY
  GMVGFSITFFVPYIFFFIGIS

• Sequence length: 441

Pathways

KEGG Pathway	Reactome Pathway
Sphingolipid metabolism	Sphingolipid de novo biosynthesis
Metabolic pathways
Sphingolipid signaling pathway

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SPTLC1 3 shared pathwaysSphingolipid metabolism, Sphingolipid signaling pathway, Sphingolipid de novo biosynthesis Related via 3 shared pathways including Sphingolipid metabolism, Sphingolipid signaling pathway. CERS1 3 shared pathwaysSphingolipid metabolism, Sphingolipid signaling pathway, Sphingolipid de novo biosynthesis Related via 3 shared pathways including Sphingolipid metabolism, Sphingolipid signaling pathway. DEGS2 3 shared pathwaysSphingolipid metabolism, Sphingolipid signaling pathway, Sphingolipid de novo biosynthesis Related via 3 shared pathways including Sphingolipid metabolism, Sphingolipid signaling pathway. ACER1 3 shared pathwaysSphingolipid metabolism, Sphingolipid signaling pathway, Sphingolipid de novo biosynthesis Related via 3 shared pathways including Sphingolipid metabolism, Sphingolipid signaling pathway. SGPP2 3 shared pathwaysSphingolipid metabolism, Sphingolipid signaling pathway, Sphingolipid de novo biosynthesis Related via 3 shared pathways including Sphingolipid metabolism, Sphingolipid signaling pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SPTLC1	0	[]	3	["Sphingolipid metabolism","Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis"]	0	[]
CERS1	0	[]	3	["Sphingolipid metabolism","Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis"]	0	[]
DEGS2	0	[]	3	["Sphingolipid metabolism","Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis"]	0	[]
ACER1	0	[]	3	["Sphingolipid metabolism","Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis"]	0	[]
SGPP2	0	[]	3	["Sphingolipid metabolism","Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 2 of 5 related genesSPTLC1, ACER1 Dementia Linked via 2 of 5 related genesSPTLC1, DEGS2 Major depressive disorder Linked via 2 of 5 related genesSPTLC1, SGPP2 Amyotrophic lateral sclerosis Linked via 1 of 5 related genesSPTLC1 Bipolar disorder Linked via 1 of 5 related genesSPTLC1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	2	["SPTLC1","ACER1"]
Dementia	2	["SPTLC1","DEGS2"]
Major depressive disorder	2	["SPTLC1","SGPP2"]
Amyotrophic lateral sclerosis	1	["SPTLC1"]
Bipolar disorder	1	["SPTLC1"]