SENP8 (SUMO peptidase family member, NEDD8 specific)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 123228
• Gene name: SUMO peptidase family member, NEDD8 specific
• Gene symbol: SENP8
• Synonyms (NCBI Gene): DEN1, NEDP1, PRSC2
• Chromosome: 15
• Chromosome location: 15q23
• Summary: This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregul

miRNA Show/Hide all (129)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002912	hsa-miR-124-3p	Microarray	18668037
MIRT634890	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT634889	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT634888	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT634887	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT634886	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT634885	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT634884	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT634883	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT634882	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT634881	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT634880	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT634879	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT634877	hsa-miR-4312	HITS-CLIP	23824327
MIRT634878	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT634876	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT634875	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT634874	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT634873	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT634872	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT634871	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT634890	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT634889	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT634888	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT627633	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT634887	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT634886	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT634885	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT634884	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT634883	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT634882	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT634881	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT634880	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT634879	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT634877	hsa-miR-4312	HITS-CLIP	23824327
MIRT634878	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT634876	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT634875	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT634874	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT634873	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT634872	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT634871	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT627637	hsa-miR-596	HITS-CLIP	23824327
MIRT627636	hsa-miR-8062	HITS-CLIP	23824327
MIRT627635	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT627634	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT627633	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT627632	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT627631	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT627630	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT627629	hsa-miR-1976	HITS-CLIP	23824327
MIRT627628	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT627627	hsa-miR-4663	HITS-CLIP	23824327
MIRT627626	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT627625	hsa-miR-8077	HITS-CLIP	23824327
MIRT627624	hsa-miR-4279	HITS-CLIP	23824327
MIRT627623	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT634890	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT634889	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT634888	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT634887	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT634886	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT634885	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT634884	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT634883	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT634882	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT634881	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT634880	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT634879	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT634877	hsa-miR-4312	HITS-CLIP	23824327
MIRT634878	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT634876	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT634875	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT634874	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT634873	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT634872	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT634871	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT634890	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT634889	hsa-miR-6838-3p	HITS-CLIP	23824327
MIRT634888	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT627633	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT634887	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT634886	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT634885	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT634884	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT634883	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT634882	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT634881	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT634880	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT634879	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT634877	hsa-miR-4312	HITS-CLIP	23824327
MIRT634878	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT634876	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT634875	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT634874	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT634873	hsa-miR-6894-3p	HITS-CLIP	23824327
MIRT634872	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT634871	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT627637	hsa-miR-596	HITS-CLIP	23824327
MIRT627636	hsa-miR-8062	HITS-CLIP	23824327
MIRT627635	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT627634	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT627633	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT627632	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT627631	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT627630	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT627629	hsa-miR-1976	HITS-CLIP	23824327
MIRT627628	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT627627	hsa-miR-4663	HITS-CLIP	23824327
MIRT627626	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT627625	hsa-miR-8077	HITS-CLIP	23824327
MIRT627624	hsa-miR-4279	HITS-CLIP	23824327
MIRT627623	hsa-miR-6869-5p	HITS-CLIP	23824327
MIRT1336047	hsa-miR-106a	CLIP-seq
MIRT1336048	hsa-miR-106b	CLIP-seq
MIRT1336049	hsa-miR-17	CLIP-seq
MIRT1336050	hsa-miR-20a	CLIP-seq
MIRT1336051	hsa-miR-20b	CLIP-seq
MIRT1336052	hsa-miR-2467-3p	CLIP-seq
MIRT1336053	hsa-miR-3145-3p	CLIP-seq
MIRT1336054	hsa-miR-3605-5p	CLIP-seq
MIRT1336055	hsa-miR-3609	CLIP-seq
MIRT1336056	hsa-miR-3678-3p	CLIP-seq
MIRT1336057	hsa-miR-3682-3p	CLIP-seq
MIRT1336058	hsa-miR-4450	CLIP-seq
MIRT1336059	hsa-miR-4796-3p	CLIP-seq
MIRT1336060	hsa-miR-519d	CLIP-seq
MIRT1336061	hsa-miR-548ah	CLIP-seq
MIRT1336062	hsa-miR-93	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000338	Process	Protein deneddylation	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019784	Function	DeNEDDylase activity	IBA
GO:0019784	Function	DeNEDDylase activity	IEA
GO:0019784	Function	DeNEDDylase activity	TAS
GO:0043687	Process	Post-translational protein modification	TAS

Other IDs

• MIM: 608659
• HGNC: 22992
• e!Ensembl: ENSG00000166192

Protein

• UniProt ID: Q96LD8
• Protein name: Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)
• Protein function: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269|PubMed:12730221, ECO:0000269|PubMed:1
• PDB: 1XT9 , 2BKQ , 2BKR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02902	Peptidase_C48	25 → 212	Ulp1 protease family, C-terminal catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Broadly expressed, with highest levels in kidney and pancreas. {ECO:0000269|PubMed:12730221}.
• Sequence:

  MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQ
  FIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDS
  HSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFR
  QQTESLLQLLTPAYITKKRGEWKDLITTLAKK

• Sequence length: 212

Pathways

Reactome Pathway

UCH proteinases

Neddylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Neurodevelopmental abnormality	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma of lung	Lung carcinoma	BEFREE	17416433		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31577950		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	17416433		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

UCHL3 2 shared pathwaysNeddylation, UCH proteinases Related via 2 shared pathways including Neddylation, UCH proteinases. NEDD8 2 shared pathwaysNeddylation, UCH proteinases Related via 2 shared pathways including Neddylation, UCH proteinases. PSMB11 2 shared pathwaysNeddylation, UCH proteinases Related via 2 shared pathways including Neddylation, UCH proteinases. PSME4 2 shared pathwaysNeddylation, UCH proteinases Related via 2 shared pathways including Neddylation, UCH proteinases. PSMA8 2 shared pathwaysNeddylation, UCH proteinases Related via 2 shared pathways including Neddylation, UCH proteinases.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
UCHL3	0	[]	2	["Neddylation","UCH proteinases"]	0	[]
NEDD8	0	[]	2	["Neddylation","UCH proteinases"]	0	[]
PSMB11	0	[]	2	["Neddylation","UCH proteinases"]	0	[]
PSME4	0	[]	2	["Neddylation","UCH proteinases"]	0	[]
PSMA8	0	[]	2	["Neddylation","UCH proteinases"]	0	[]

Diseases Linked via Similar Genes

Diabetic retinopathy Linked via 1 of 5 related genesUCHL3 Prostate cancer Linked via 1 of 5 related genesNEDD8 Alzheimer disease Linked via 1 of 5 related genesPSME4 Metabolic syndrome Linked via 1 of 5 related genesPSME4 Osteoarthritis Linked via 1 of 5 related genesPSME4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetic retinopathy	1	["UCHL3"]
Prostate cancer	1	["NEDD8"]
Alzheimer disease	1	["PSME4"]
Metabolic syndrome	1	["PSME4"]
Osteoarthritis	1	["PSME4"]