RPS6KL1 (ribosomal protein S6 kinase like 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83694
• Gene name: Ribosomal protein S6 kinase like 1
• Gene symbol: RPS6KL1
• Synonyms (NCBI Gene): RSKL2
• Chromosome: 14
• Chromosome location: 14q24.3

miRNA Show/Hide all (216)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1318906	hsa-miR-1185	CLIP-seq
MIRT1318907	hsa-miR-1200	CLIP-seq
MIRT1318908	hsa-miR-1208	CLIP-seq
MIRT1318909	hsa-miR-1224-3p	CLIP-seq
MIRT1318910	hsa-miR-1236	CLIP-seq
MIRT1318911	hsa-miR-1260	CLIP-seq
MIRT1318912	hsa-miR-1260b	CLIP-seq
MIRT1318913	hsa-miR-1273g	CLIP-seq
MIRT1318914	hsa-miR-1280	CLIP-seq
MIRT1318915	hsa-miR-1285	CLIP-seq
MIRT1318916	hsa-miR-1286	CLIP-seq
MIRT1318917	hsa-miR-1291	CLIP-seq
MIRT1318918	hsa-miR-1294	CLIP-seq
MIRT1318919	hsa-miR-1321	CLIP-seq
MIRT1318920	hsa-miR-1343	CLIP-seq
MIRT1318921	hsa-miR-140-3p	CLIP-seq
MIRT1318922	hsa-miR-146a	CLIP-seq
MIRT1318923	hsa-miR-146b-5p	CLIP-seq
MIRT1318924	hsa-miR-147	CLIP-seq
MIRT1318925	hsa-miR-149	CLIP-seq
MIRT1318926	hsa-miR-1827	CLIP-seq
MIRT1318927	hsa-miR-188-3p	CLIP-seq
MIRT1318928	hsa-miR-1915	CLIP-seq
MIRT1318929	hsa-miR-198	CLIP-seq
MIRT1318930	hsa-miR-2114	CLIP-seq
MIRT1318931	hsa-miR-218	CLIP-seq
MIRT1318932	hsa-miR-2355-5p	CLIP-seq
MIRT1318933	hsa-miR-28-5p	CLIP-seq
MIRT1318934	hsa-miR-2861	CLIP-seq
MIRT1318935	hsa-miR-3064-5p	CLIP-seq
MIRT1318936	hsa-miR-30a	CLIP-seq
MIRT1318937	hsa-miR-30b	CLIP-seq
MIRT1318938	hsa-miR-30c	CLIP-seq
MIRT1318939	hsa-miR-30d	CLIP-seq
MIRT1318940	hsa-miR-30e	CLIP-seq
MIRT1318941	hsa-miR-3120-5p	CLIP-seq
MIRT1318942	hsa-miR-3139	CLIP-seq
MIRT1318943	hsa-miR-3147	CLIP-seq
MIRT1318944	hsa-miR-3156-3p	CLIP-seq
MIRT1318945	hsa-miR-3162-5p	CLIP-seq
MIRT1318946	hsa-miR-3174	CLIP-seq
MIRT1318947	hsa-miR-3180-5p	CLIP-seq
MIRT1318948	hsa-miR-3187-5p	CLIP-seq
MIRT1318949	hsa-miR-323-3p	CLIP-seq
MIRT1318950	hsa-miR-328	CLIP-seq
MIRT1318951	hsa-miR-339-5p	CLIP-seq
MIRT1318952	hsa-miR-346	CLIP-seq
MIRT1318953	hsa-miR-34a	CLIP-seq
MIRT1318954	hsa-miR-34c-5p	CLIP-seq
MIRT1318955	hsa-miR-3545-5p	CLIP-seq
MIRT1318956	hsa-miR-3605-5p	CLIP-seq
MIRT1318957	hsa-miR-3619-3p	CLIP-seq
MIRT1318958	hsa-miR-3622a-5p	CLIP-seq
MIRT1318959	hsa-miR-3652	CLIP-seq
MIRT1318960	hsa-miR-3657	CLIP-seq
MIRT1318961	hsa-miR-3667-3p	CLIP-seq
MIRT1318962	hsa-miR-3679-5p	CLIP-seq
MIRT1318963	hsa-miR-378g	CLIP-seq
MIRT1318964	hsa-miR-3911	CLIP-seq
MIRT1318965	hsa-miR-3919	CLIP-seq
MIRT1318966	hsa-miR-3936	CLIP-seq
MIRT1318967	hsa-miR-3942-3p	CLIP-seq
MIRT1318968	hsa-miR-3977	CLIP-seq
MIRT1318969	hsa-miR-4251	CLIP-seq
MIRT1318970	hsa-miR-4259	CLIP-seq
MIRT1318971	hsa-miR-4265	CLIP-seq
MIRT1318972	hsa-miR-4266	CLIP-seq
MIRT1318973	hsa-miR-4267	CLIP-seq
MIRT1318974	hsa-miR-4269	CLIP-seq
MIRT1318975	hsa-miR-4270	CLIP-seq
MIRT1318976	hsa-miR-4276	CLIP-seq
MIRT1318977	hsa-miR-4288	CLIP-seq
MIRT1318978	hsa-miR-4293	CLIP-seq
MIRT1318979	hsa-miR-4296	CLIP-seq
MIRT1318980	hsa-miR-4313	CLIP-seq
MIRT1318981	hsa-miR-4314	CLIP-seq
MIRT1318982	hsa-miR-4316	CLIP-seq
MIRT1318983	hsa-miR-4322	CLIP-seq
MIRT1318984	hsa-miR-4324	CLIP-seq
MIRT1318985	hsa-miR-433	CLIP-seq
MIRT1318986	hsa-miR-4417	CLIP-seq
MIRT1318987	hsa-miR-4421	CLIP-seq
MIRT1318988	hsa-miR-4430	CLIP-seq
MIRT1318989	hsa-miR-4436a	CLIP-seq
MIRT1318990	hsa-miR-4441	CLIP-seq
MIRT1318991	hsa-miR-4469	CLIP-seq
MIRT1318992	hsa-miR-4486	CLIP-seq
MIRT1318993	hsa-miR-4487	CLIP-seq
MIRT1318994	hsa-miR-449a	CLIP-seq
MIRT1318995	hsa-miR-449b	CLIP-seq
MIRT1318996	hsa-miR-4505	CLIP-seq
MIRT1318997	hsa-miR-4645-5p	CLIP-seq
MIRT1318998	hsa-miR-4669	CLIP-seq
MIRT1318999	hsa-miR-4673	CLIP-seq
MIRT1319000	hsa-miR-4676-5p	CLIP-seq
MIRT1319001	hsa-miR-4677-3p	CLIP-seq
MIRT1319002	hsa-miR-4683	CLIP-seq
MIRT1319003	hsa-miR-4685-5p	CLIP-seq
MIRT1319004	hsa-miR-4738-3p	CLIP-seq
MIRT1319005	hsa-miR-4739	CLIP-seq
MIRT1319006	hsa-miR-4755-3p	CLIP-seq
MIRT1319007	hsa-miR-4756-3p	CLIP-seq
MIRT1319008	hsa-miR-4756-5p	CLIP-seq
MIRT1319009	hsa-miR-4759	CLIP-seq
MIRT1319010	hsa-miR-4776-5p	CLIP-seq
MIRT1319011	hsa-miR-4786-5p	CLIP-seq
MIRT1319012	hsa-miR-4794	CLIP-seq
MIRT1319013	hsa-miR-4795-5p	CLIP-seq
MIRT1319014	hsa-miR-4800-5p	CLIP-seq
MIRT1319015	hsa-miR-511	CLIP-seq
MIRT1319016	hsa-miR-520a-5p	CLIP-seq
MIRT1319017	hsa-miR-525-5p	CLIP-seq
MIRT1319018	hsa-miR-544b	CLIP-seq
MIRT1319019	hsa-miR-575	CLIP-seq
MIRT1319020	hsa-miR-582-3p	CLIP-seq
MIRT1319021	hsa-miR-589	CLIP-seq
MIRT1319022	hsa-miR-612	CLIP-seq
MIRT1319023	hsa-miR-622	CLIP-seq
MIRT1319024	hsa-miR-632	CLIP-seq
MIRT1319025	hsa-miR-636	CLIP-seq
MIRT1319026	hsa-miR-642a	CLIP-seq
MIRT1319027	hsa-miR-644	CLIP-seq
MIRT1319028	hsa-miR-665	CLIP-seq
MIRT1319029	hsa-miR-708	CLIP-seq
MIRT1319030	hsa-miR-766	CLIP-seq
MIRT1319031	hsa-miR-876-3p	CLIP-seq
MIRT1319032	hsa-miR-940	CLIP-seq
MIRT1318965	hsa-miR-3919	CLIP-seq
MIRT1318967	hsa-miR-3942-3p	CLIP-seq
MIRT1319007	hsa-miR-4756-3p	CLIP-seq
MIRT2094829	hsa-miR-1254	CLIP-seq
MIRT2094830	hsa-miR-129-3p	CLIP-seq
MIRT2094831	hsa-miR-134	CLIP-seq
MIRT2094832	hsa-miR-214	CLIP-seq
MIRT2094833	hsa-miR-219-2-3p	CLIP-seq
MIRT1318932	hsa-miR-2355-5p	CLIP-seq
MIRT2094834	hsa-miR-2964a-3p	CLIP-seq
MIRT2094835	hsa-miR-302f	CLIP-seq
MIRT2094836	hsa-miR-3116	CLIP-seq
MIRT2094837	hsa-miR-3118	CLIP-seq
MIRT2094838	hsa-miR-3136-5p	CLIP-seq
MIRT2094839	hsa-miR-3170	CLIP-seq
MIRT1318946	hsa-miR-3174	CLIP-seq
MIRT2094840	hsa-miR-323-5p	CLIP-seq
MIRT1318953	hsa-miR-34a	CLIP-seq
MIRT1318954	hsa-miR-34c-5p	CLIP-seq
MIRT2094841	hsa-miR-3611	CLIP-seq
MIRT2094842	hsa-miR-3619-5p	CLIP-seq
MIRT2094843	hsa-miR-3665	CLIP-seq
MIRT1318965	hsa-miR-3919	CLIP-seq
MIRT2094844	hsa-miR-421	CLIP-seq
MIRT2094845	hsa-miR-4260	CLIP-seq
MIRT1318984	hsa-miR-4324	CLIP-seq
MIRT2094846	hsa-miR-4438	CLIP-seq
MIRT2094847	hsa-miR-4439	CLIP-seq
MIRT1318993	hsa-miR-4487	CLIP-seq
MIRT1318994	hsa-miR-449a	CLIP-seq
MIRT1318995	hsa-miR-449b	CLIP-seq
MIRT2094848	hsa-miR-4530	CLIP-seq
MIRT2094849	hsa-miR-4680-3p	CLIP-seq
MIRT2094850	hsa-miR-4690-5p	CLIP-seq
MIRT2094851	hsa-miR-4709-5p	CLIP-seq
MIRT1319007	hsa-miR-4756-3p	CLIP-seq
MIRT2094852	hsa-miR-4786-3p	CLIP-seq
MIRT2094853	hsa-miR-486-3p	CLIP-seq
MIRT2094854	hsa-miR-505	CLIP-seq
MIRT2094855	hsa-miR-5095	CLIP-seq
MIRT2094856	hsa-miR-615-5p	CLIP-seq
MIRT2094857	hsa-miR-671-5p	CLIP-seq
MIRT2094858	hsa-miR-758	CLIP-seq
MIRT2094859	hsa-miR-761	CLIP-seq
MIRT1319030	hsa-miR-766	CLIP-seq
MIRT2319227	hsa-miR-1207-5p	CLIP-seq
MIRT2319228	hsa-miR-1267	CLIP-seq
MIRT2319229	hsa-miR-128	CLIP-seq
MIRT2319230	hsa-miR-129-5p	CLIP-seq
MIRT2319231	hsa-miR-133a	CLIP-seq
MIRT2319232	hsa-miR-133b	CLIP-seq
MIRT2094831	hsa-miR-134	CLIP-seq
MIRT2319233	hsa-miR-140-5p	CLIP-seq
MIRT2319234	hsa-miR-185	CLIP-seq
MIRT2319235	hsa-miR-2682	CLIP-seq
MIRT2319236	hsa-miR-27a	CLIP-seq
MIRT2319237	hsa-miR-27b	CLIP-seq
MIRT2094837	hsa-miR-3118	CLIP-seq
MIRT2319238	hsa-miR-3132	CLIP-seq
MIRT2094838	hsa-miR-3136-5p	CLIP-seq
MIRT2319239	hsa-miR-3164	CLIP-seq
MIRT2319240	hsa-miR-4286	CLIP-seq
MIRT2319241	hsa-miR-4306	CLIP-seq
MIRT2319242	hsa-miR-4307	CLIP-seq
MIRT1318984	hsa-miR-4324	CLIP-seq
MIRT1318989	hsa-miR-4436a	CLIP-seq
MIRT2094847	hsa-miR-4439	CLIP-seq
MIRT2319243	hsa-miR-449c	CLIP-seq
MIRT2319244	hsa-miR-4513	CLIP-seq
MIRT2319245	hsa-miR-4644	CLIP-seq
MIRT1319000	hsa-miR-4676-5p	CLIP-seq
MIRT2319246	hsa-miR-4679	CLIP-seq
MIRT2319247	hsa-miR-4736	CLIP-seq
MIRT2319248	hsa-miR-4763-3p	CLIP-seq
MIRT1319015	hsa-miR-511	CLIP-seq
MIRT2319249	hsa-miR-516b	CLIP-seq
MIRT1319019	hsa-miR-575	CLIP-seq
MIRT1319023	hsa-miR-622	CLIP-seq
MIRT2319250	hsa-miR-720	CLIP-seq
MIRT1319032	hsa-miR-940	CLIP-seq
MIRT2319251	hsa-miR-943	CLIP-seq
MIRT2094839	hsa-miR-3170	CLIP-seq
MIRT2094845	hsa-miR-4260	CLIP-seq
MIRT2094856	hsa-miR-615-5p	CLIP-seq
MIRT2094839	hsa-miR-3170	CLIP-seq
MIRT2094841	hsa-miR-3611	CLIP-seq
MIRT2094845	hsa-miR-4260	CLIP-seq
MIRT2094856	hsa-miR-615-5p	CLIP-seq
MIRT2094858	hsa-miR-758	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005524	Function	ATP binding	IEA
GO:0005840	Component	Ribosome	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9Y6S9
• Protein name: Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04212	MIT	50 → 115	MIT (microtubule interacting and transport) domain	Domain
  PF00069	Pkinase	375 → 539	Protein kinase domain	Domain

• Sequence:

  MSLVACECLPSPGLEPEPCSRARSQAHVYLEQIRNRVALGVPDMTKRDYLVDAATQIRLA
  LERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKLKITKYLRRAEEIFNCHLQR
  PLSSGASPSAGFSSLRLRPIRTLSSAVEQLRGCRVVGVIEKVQLVQDPATGGTFVVKSLP
  RCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQAHSRHSGL
  SSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQR
  EAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCG
  RGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLL
  DQAGHIRLTYFGQWSEVEPQCCGEAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTG
  MALSQSHPSGIQAHTQLQLPEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFFS
  TIQWSKLVG

• Sequence length: 549

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (12)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	29255261, 29942085	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	31701892	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	37945903	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	37945903	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GWAS catalog	31835028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

C8orf90 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. DGKI 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. HSPE1-MOB4 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. MOB4 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. NAA40 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
C8orf90	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
DGKI	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
HSPE1-MOB4	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
MOB4	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]
NAA40	3	["Anorexia nervosa","Tourette syndrome","Obsessive-compulsive disorder"]	0	[]	3	["GWAS catalog (Anorexia nervosa)","GWAS catalog (Obsessive-compulsive disorder)","GWAS catalog (Tourette syndrome)"]

Diseases Linked via Similar Genes

Insomnia Linked via 3 of 5 related genesDGKI, HSPE1-MOB4, MOB4 Alzheimer disease Linked via 2 of 5 related genesC8orf90, DGKI Metabolic syndrome Linked via 2 of 5 related genesC8orf90, DGKI Obesity Linked via 2 of 5 related genesC8orf90, DGKI Diabetes mellitus type 2 Linked via 2 of 5 related genesC8orf90, DGKI

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Insomnia	3	["DGKI","HSPE1-MOB4","MOB4"]
Alzheimer disease	2	["C8orf90","DGKI"]
Metabolic syndrome	2	["C8orf90","DGKI"]
Obesity	2	["C8orf90","DGKI"]
Diabetes mellitus type 2	2	["C8orf90","DGKI"]