Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	27330
Gene name	Ribosomal protein S6 kinase A6
Gene symbol	RPS6KA6
Synonyms (NCBI Gene)	PP90RSK4RSK-4RSK4S6K-alpha-6p90RSK6
Chromosome	X
Chromosome location	Xq21.1
Summary	This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor de

345 Show/Hide all (345)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017599	hsa-miR-335-5p	Microarray	18185580
MIRT029385	hsa-miR-26b-5p	Microarray	19088304
MIRT443722	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT443722	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT1318406	hsa-miR-103a	CLIP-seq
MIRT1318407	hsa-miR-106a	CLIP-seq
MIRT1318408	hsa-miR-106b	CLIP-seq
MIRT1318409	hsa-miR-107	CLIP-seq
MIRT1318410	hsa-miR-1228	CLIP-seq
MIRT1318411	hsa-miR-1234	CLIP-seq
MIRT1318412	hsa-miR-1252	CLIP-seq
MIRT1318413	hsa-miR-125a-3p	CLIP-seq
MIRT1318414	hsa-miR-1273e	CLIP-seq
MIRT1318415	hsa-miR-1294	CLIP-seq
MIRT1318416	hsa-miR-1297	CLIP-seq
MIRT1318417	hsa-miR-135a	CLIP-seq
MIRT1318418	hsa-miR-135b	CLIP-seq
MIRT1318419	hsa-miR-137	CLIP-seq
MIRT1318420	hsa-miR-139-3p	CLIP-seq
MIRT1318421	hsa-miR-150	CLIP-seq
MIRT1318422	hsa-miR-15a	CLIP-seq
MIRT1318423	hsa-miR-15b	CLIP-seq
MIRT1318424	hsa-miR-16	CLIP-seq
MIRT1318425	hsa-miR-17	CLIP-seq
MIRT1318426	hsa-miR-195	CLIP-seq
MIRT1318427	hsa-miR-20a	CLIP-seq
MIRT1318428	hsa-miR-20b	CLIP-seq
MIRT1318429	hsa-miR-26a	CLIP-seq
MIRT1318430	hsa-miR-26b	CLIP-seq
MIRT1318431	hsa-miR-28-3p	CLIP-seq
MIRT1318432	hsa-miR-302a	CLIP-seq
MIRT1318433	hsa-miR-302b	CLIP-seq
MIRT1318434	hsa-miR-302c	CLIP-seq
MIRT1318435	hsa-miR-302d	CLIP-seq
MIRT1318436	hsa-miR-302e	CLIP-seq
MIRT1318437	hsa-miR-3125	CLIP-seq
MIRT1318438	hsa-miR-3134	CLIP-seq
MIRT1318439	hsa-miR-3143	CLIP-seq
MIRT1318440	hsa-miR-3149	CLIP-seq
MIRT1318441	hsa-miR-33a	CLIP-seq
MIRT1318442	hsa-miR-33b	CLIP-seq
MIRT1318443	hsa-miR-3688-3p	CLIP-seq
MIRT1318444	hsa-miR-372	CLIP-seq
MIRT1318445	hsa-miR-373	CLIP-seq
MIRT1318446	hsa-miR-3907	CLIP-seq
MIRT1318447	hsa-miR-3916	CLIP-seq
MIRT1318448	hsa-miR-3934	CLIP-seq
MIRT1318449	hsa-miR-411	CLIP-seq
MIRT1318450	hsa-miR-424	CLIP-seq
MIRT1318451	hsa-miR-4272	CLIP-seq
MIRT1318452	hsa-miR-4289	CLIP-seq
MIRT1318453	hsa-miR-4310	CLIP-seq
MIRT1318454	hsa-miR-4316	CLIP-seq
MIRT1318455	hsa-miR-4327	CLIP-seq
MIRT1318456	hsa-miR-4438	CLIP-seq
MIRT1318457	hsa-miR-4465	CLIP-seq
MIRT1318458	hsa-miR-4476	CLIP-seq
MIRT1318459	hsa-miR-4524	CLIP-seq
MIRT1318460	hsa-miR-4533	CLIP-seq
MIRT1318461	hsa-miR-4534	CLIP-seq
MIRT1318462	hsa-miR-4637	CLIP-seq
MIRT1318463	hsa-miR-4677-3p	CLIP-seq
MIRT1318464	hsa-miR-4787-3p	CLIP-seq
MIRT1318465	hsa-miR-4794	CLIP-seq
MIRT1318466	hsa-miR-483-5p	CLIP-seq
MIRT1318467	hsa-miR-496	CLIP-seq
MIRT1318468	hsa-miR-497	CLIP-seq
MIRT1318469	hsa-miR-503	CLIP-seq
MIRT1318470	hsa-miR-5095	CLIP-seq
MIRT1318471	hsa-miR-519d	CLIP-seq
MIRT1318472	hsa-miR-520a-3p	CLIP-seq
MIRT1318473	hsa-miR-520b	CLIP-seq
MIRT1318474	hsa-miR-520c-3p	CLIP-seq
MIRT1318475	hsa-miR-520d-3p	CLIP-seq
MIRT1318476	hsa-miR-520e	CLIP-seq
MIRT1318477	hsa-miR-520g	CLIP-seq
MIRT1318478	hsa-miR-520h	CLIP-seq
MIRT1318479	hsa-miR-543	CLIP-seq
MIRT1318480	hsa-miR-548c-3p	CLIP-seq
MIRT1318481	hsa-miR-577	CLIP-seq
MIRT1318482	hsa-miR-616	CLIP-seq
MIRT1318483	hsa-miR-640	CLIP-seq
MIRT1318484	hsa-miR-646	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT1318486	hsa-miR-764	CLIP-seq
MIRT1318487	hsa-miR-889	CLIP-seq
MIRT1318488	hsa-miR-93	CLIP-seq
MIRT1318411	hsa-miR-1234	CLIP-seq
MIRT1318421	hsa-miR-150	CLIP-seq
MIRT1318477	hsa-miR-520g	CLIP-seq
MIRT1318478	hsa-miR-520h	CLIP-seq
MIRT1318483	hsa-miR-640	CLIP-seq
MIRT1318420	hsa-miR-139-3p	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT1318420	hsa-miR-139-3p	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT1318420	hsa-miR-139-3p	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT1318407	hsa-miR-106a	CLIP-seq
MIRT1318408	hsa-miR-106b	CLIP-seq
MIRT1318410	hsa-miR-1228	CLIP-seq
MIRT1318411	hsa-miR-1234	CLIP-seq
MIRT2094684	hsa-miR-1271	CLIP-seq
MIRT1318416	hsa-miR-1297	CLIP-seq
MIRT2094685	hsa-miR-1307	CLIP-seq
MIRT1318420	hsa-miR-139-3p	CLIP-seq
MIRT2094686	hsa-miR-144	CLIP-seq
MIRT1318421	hsa-miR-150	CLIP-seq
MIRT1318425	hsa-miR-17	CLIP-seq
MIRT2094687	hsa-miR-182	CLIP-seq
MIRT2094688	hsa-miR-186	CLIP-seq
MIRT2094689	hsa-miR-1915	CLIP-seq
MIRT2094690	hsa-miR-199a-3p	CLIP-seq
MIRT2094691	hsa-miR-199b-3p	CLIP-seq
MIRT1318427	hsa-miR-20a	CLIP-seq
MIRT1318428	hsa-miR-20b	CLIP-seq
MIRT2094692	hsa-miR-218	CLIP-seq
MIRT1318429	hsa-miR-26a	CLIP-seq
MIRT1318430	hsa-miR-26b	CLIP-seq
MIRT1318432	hsa-miR-302a	CLIP-seq
MIRT1318433	hsa-miR-302b	CLIP-seq
MIRT1318434	hsa-miR-302c	CLIP-seq
MIRT1318435	hsa-miR-302d	CLIP-seq
MIRT1318436	hsa-miR-302e	CLIP-seq
MIRT2094693	hsa-miR-3129-5p	CLIP-seq
MIRT1318439	hsa-miR-3143	CLIP-seq
MIRT2094694	hsa-miR-3148	CLIP-seq
MIRT1318440	hsa-miR-3149	CLIP-seq
MIRT2094695	hsa-miR-3622b-5p	CLIP-seq
MIRT1318444	hsa-miR-372	CLIP-seq
MIRT1318445	hsa-miR-373	CLIP-seq
MIRT2094696	hsa-miR-4252	CLIP-seq
MIRT2094697	hsa-miR-4284	CLIP-seq
MIRT1318457	hsa-miR-4465	CLIP-seq
MIRT2094698	hsa-miR-4509	CLIP-seq
MIRT2094699	hsa-miR-4638-5p	CLIP-seq
MIRT2094700	hsa-miR-4642	CLIP-seq
MIRT2094701	hsa-miR-4694-3p	CLIP-seq
MIRT2094702	hsa-miR-4698	CLIP-seq
MIRT2094703	hsa-miR-4726-3p	CLIP-seq
MIRT2094704	hsa-miR-4744	CLIP-seq
MIRT2094705	hsa-miR-4778-3p	CLIP-seq
MIRT1318465	hsa-miR-4794	CLIP-seq
MIRT2094706	hsa-miR-512-3p	CLIP-seq
MIRT1318471	hsa-miR-519d	CLIP-seq
MIRT1318472	hsa-miR-520a-3p	CLIP-seq
MIRT1318473	hsa-miR-520b	CLIP-seq
MIRT1318474	hsa-miR-520c-3p	CLIP-seq
MIRT1318475	hsa-miR-520d-3p	CLIP-seq
MIRT1318476	hsa-miR-520e	CLIP-seq
MIRT1318477	hsa-miR-520g	CLIP-seq
MIRT1318478	hsa-miR-520h	CLIP-seq
MIRT2094707	hsa-miR-522	CLIP-seq
MIRT2094708	hsa-miR-561	CLIP-seq
MIRT2094709	hsa-miR-636	CLIP-seq
MIRT1318483	hsa-miR-640	CLIP-seq
MIRT2094710	hsa-miR-654-3p	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT2094711	hsa-miR-9	CLIP-seq
MIRT1318488	hsa-miR-93	CLIP-seq
MIRT2094712	hsa-miR-96	CLIP-seq
MIRT1318407	hsa-miR-106a	CLIP-seq
MIRT1318408	hsa-miR-106b	CLIP-seq
MIRT2319166	hsa-miR-1200	CLIP-seq
MIRT1318410	hsa-miR-1228	CLIP-seq
MIRT1318411	hsa-miR-1234	CLIP-seq
MIRT2319167	hsa-miR-1237	CLIP-seq
MIRT2319168	hsa-miR-1244	CLIP-seq
MIRT2319169	hsa-miR-1248	CLIP-seq
MIRT1318413	hsa-miR-125a-3p	CLIP-seq
MIRT2319170	hsa-miR-1283	CLIP-seq
MIRT1318416	hsa-miR-1297	CLIP-seq
MIRT2094685	hsa-miR-1307	CLIP-seq
MIRT2319171	hsa-miR-139-5p	CLIP-seq
MIRT2094686	hsa-miR-144	CLIP-seq
MIRT1318421	hsa-miR-150	CLIP-seq
MIRT1318425	hsa-miR-17	CLIP-seq
MIRT2319172	hsa-miR-181a	CLIP-seq
MIRT2319173	hsa-miR-181b	CLIP-seq
MIRT2319174	hsa-miR-181c	CLIP-seq
MIRT2319175	hsa-miR-181d	CLIP-seq
MIRT2094689	hsa-miR-1915	CLIP-seq
MIRT2319176	hsa-miR-1976	CLIP-seq
MIRT2094690	hsa-miR-199a-3p	CLIP-seq
MIRT2094691	hsa-miR-199b-3p	CLIP-seq
MIRT1318427	hsa-miR-20a	CLIP-seq
MIRT1318428	hsa-miR-20b	CLIP-seq
MIRT2319177	hsa-miR-223	CLIP-seq
MIRT1318429	hsa-miR-26a	CLIP-seq
MIRT1318430	hsa-miR-26b	CLIP-seq
MIRT1318432	hsa-miR-302a	CLIP-seq
MIRT1318433	hsa-miR-302b	CLIP-seq
MIRT1318434	hsa-miR-302c	CLIP-seq
MIRT1318435	hsa-miR-302d	CLIP-seq
MIRT1318436	hsa-miR-302e	CLIP-seq
MIRT2319178	hsa-miR-3074-3p	CLIP-seq
MIRT2319179	hsa-miR-3120-3p	CLIP-seq
MIRT2094693	hsa-miR-3129-5p	CLIP-seq
MIRT2319180	hsa-miR-3174	CLIP-seq
MIRT2319181	hsa-miR-323-3p	CLIP-seq
MIRT2319182	hsa-miR-340	CLIP-seq
MIRT2319183	hsa-miR-3662	CLIP-seq
MIRT1318444	hsa-miR-372	CLIP-seq
MIRT1318445	hsa-miR-373	CLIP-seq
MIRT1318448	hsa-miR-3934	CLIP-seq
MIRT2319184	hsa-miR-410	CLIP-seq
MIRT2094696	hsa-miR-4252	CLIP-seq
MIRT2319185	hsa-miR-4262	CLIP-seq
MIRT2319186	hsa-miR-4279	CLIP-seq
MIRT2094697	hsa-miR-4284	CLIP-seq
MIRT2319187	hsa-miR-4307	CLIP-seq
MIRT2319188	hsa-miR-4324	CLIP-seq
MIRT2319189	hsa-miR-4328	CLIP-seq
MIRT2319190	hsa-miR-433	CLIP-seq
MIRT2319191	hsa-miR-4421	CLIP-seq
MIRT1318456	hsa-miR-4438	CLIP-seq
MIRT2319192	hsa-miR-4448	CLIP-seq
MIRT2319193	hsa-miR-4452	CLIP-seq
MIRT1318457	hsa-miR-4465	CLIP-seq
MIRT2319194	hsa-miR-4477b	CLIP-seq
MIRT2319195	hsa-miR-451b	CLIP-seq
MIRT2094699	hsa-miR-4638-5p	CLIP-seq
MIRT2319196	hsa-miR-4645-3p	CLIP-seq
MIRT2319197	hsa-miR-4652-3p	CLIP-seq
MIRT2319198	hsa-miR-4684-5p	CLIP-seq
MIRT2319199	hsa-miR-4697-3p	CLIP-seq
MIRT2094702	hsa-miR-4698	CLIP-seq
MIRT2319200	hsa-miR-4720-3p	CLIP-seq
MIRT2094703	hsa-miR-4726-3p	CLIP-seq
MIRT2319201	hsa-miR-4731-5p	CLIP-seq
MIRT2319202	hsa-miR-4768-5p	CLIP-seq
MIRT2094705	hsa-miR-4778-3p	CLIP-seq
MIRT1318464	hsa-miR-4787-3p	CLIP-seq
MIRT1318465	hsa-miR-4794	CLIP-seq
MIRT2319203	hsa-miR-4804-3p	CLIP-seq
MIRT2319204	hsa-miR-488	CLIP-seq
MIRT1318470	hsa-miR-5095	CLIP-seq
MIRT2094706	hsa-miR-512-3p	CLIP-seq
MIRT1318471	hsa-miR-519d	CLIP-seq
MIRT1318472	hsa-miR-520a-3p	CLIP-seq
MIRT1318473	hsa-miR-520b	CLIP-seq
MIRT1318474	hsa-miR-520c-3p	CLIP-seq
MIRT1318475	hsa-miR-520d-3p	CLIP-seq
MIRT1318476	hsa-miR-520e	CLIP-seq
MIRT1318477	hsa-miR-520g	CLIP-seq
MIRT1318478	hsa-miR-520h	CLIP-seq
MIRT2319205	hsa-miR-544b	CLIP-seq
MIRT2319206	hsa-miR-567	CLIP-seq
MIRT2319207	hsa-miR-606	CLIP-seq
MIRT1318483	hsa-miR-640	CLIP-seq
MIRT1318486	hsa-miR-764	CLIP-seq
MIRT2319208	hsa-miR-802	CLIP-seq
MIRT1318488	hsa-miR-93	CLIP-seq
MIRT2319209	hsa-miR-936	CLIP-seq
MIRT2393888	hsa-miR-3128	CLIP-seq
MIRT2393889	hsa-miR-3194-3p	CLIP-seq
MIRT2319187	hsa-miR-4307	CLIP-seq
MIRT2094702	hsa-miR-4698	CLIP-seq
MIRT2393890	hsa-miR-4719	CLIP-seq
MIRT2393891	hsa-miR-4720-5p	CLIP-seq
MIRT2393892	hsa-miR-4799-3p	CLIP-seq
MIRT1318420	hsa-miR-139-3p	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT2439981	hsa-miR-142-5p	CLIP-seq
MIRT2094686	hsa-miR-144	CLIP-seq
MIRT2319182	hsa-miR-340	CLIP-seq
MIRT2439982	hsa-miR-4280	CLIP-seq
MIRT2439983	hsa-miR-4703-3p	CLIP-seq
MIRT2439984	hsa-miR-4709-5p	CLIP-seq
MIRT2439985	hsa-miR-4729	CLIP-seq
MIRT2439986	hsa-miR-579	CLIP-seq
MIRT1318485	hsa-miR-758	CLIP-seq
MIRT2319166	hsa-miR-1200	CLIP-seq
MIRT1318416	hsa-miR-1297	CLIP-seq
MIRT2094689	hsa-miR-1915	CLIP-seq
MIRT2319176	hsa-miR-1976	CLIP-seq
MIRT1318429	hsa-miR-26a	CLIP-seq
MIRT1318430	hsa-miR-26b	CLIP-seq
MIRT2319186	hsa-miR-4279	CLIP-seq
MIRT2319188	hsa-miR-4324	CLIP-seq
MIRT2319191	hsa-miR-4421	CLIP-seq
MIRT1318457	hsa-miR-4465	CLIP-seq
MIRT2094703	hsa-miR-4726-3p	CLIP-seq
MIRT2319205	hsa-miR-544b	CLIP-seq
MIRT1318407	hsa-miR-106a	CLIP-seq
MIRT1318408	hsa-miR-106b	CLIP-seq
MIRT2319166	hsa-miR-1200	CLIP-seq
MIRT2319168	hsa-miR-1244	CLIP-seq
MIRT1318416	hsa-miR-1297	CLIP-seq
MIRT2439981	hsa-miR-142-5p	CLIP-seq
MIRT2094686	hsa-miR-144	CLIP-seq
MIRT1318421	hsa-miR-150	CLIP-seq
MIRT1318425	hsa-miR-17	CLIP-seq
MIRT2094689	hsa-miR-1915	CLIP-seq
MIRT2319176	hsa-miR-1976	CLIP-seq
MIRT1318427	hsa-miR-20a	CLIP-seq
MIRT1318428	hsa-miR-20b	CLIP-seq
MIRT1318429	hsa-miR-26a	CLIP-seq
MIRT1318430	hsa-miR-26b	CLIP-seq
MIRT1318432	hsa-miR-302a	CLIP-seq
MIRT1318433	hsa-miR-302b	CLIP-seq
MIRT1318434	hsa-miR-302c	CLIP-seq
MIRT1318435	hsa-miR-302d	CLIP-seq
MIRT1318436	hsa-miR-302e	CLIP-seq
MIRT2319182	hsa-miR-340	CLIP-seq
MIRT1318444	hsa-miR-372	CLIP-seq
MIRT1318445	hsa-miR-373	CLIP-seq
MIRT2614774	hsa-miR-376a	CLIP-seq
MIRT2614775	hsa-miR-376b	CLIP-seq
MIRT2319186	hsa-miR-4279	CLIP-seq
MIRT2319188	hsa-miR-4324	CLIP-seq
MIRT2319191	hsa-miR-4421	CLIP-seq
MIRT1318456	hsa-miR-4438	CLIP-seq
MIRT1318457	hsa-miR-4465	CLIP-seq
MIRT2439984	hsa-miR-4709-5p	CLIP-seq
MIRT2094703	hsa-miR-4726-3p	CLIP-seq
MIRT2319201	hsa-miR-4731-5p	CLIP-seq
MIRT1318470	hsa-miR-5095	CLIP-seq
MIRT2094706	hsa-miR-512-3p	CLIP-seq
MIRT1318471	hsa-miR-519d	CLIP-seq
MIRT1318472	hsa-miR-520a-3p	CLIP-seq
MIRT1318473	hsa-miR-520b	CLIP-seq
MIRT1318474	hsa-miR-520c-3p	CLIP-seq
MIRT1318475	hsa-miR-520d-3p	CLIP-seq
MIRT1318476	hsa-miR-520e	CLIP-seq
MIRT1318477	hsa-miR-520g	CLIP-seq
MIRT1318478	hsa-miR-520h	CLIP-seq
MIRT2319205	hsa-miR-544b	CLIP-seq
MIRT1318488	hsa-miR-93	CLIP-seq
MIRT1318416	hsa-miR-1297	CLIP-seq
MIRT2094689	hsa-miR-1915	CLIP-seq
MIRT2319176	hsa-miR-1976	CLIP-seq
MIRT1318429	hsa-miR-26a	CLIP-seq
MIRT1318430	hsa-miR-26b	CLIP-seq
MIRT2690030	hsa-miR-3159	CLIP-seq
MIRT2690031	hsa-miR-3654	CLIP-seq
MIRT2614774	hsa-miR-376a	CLIP-seq
MIRT2614775	hsa-miR-376b	CLIP-seq
MIRT2319186	hsa-miR-4279	CLIP-seq
MIRT2319191	hsa-miR-4421	CLIP-seq
MIRT2690032	hsa-miR-4423-3p	CLIP-seq
MIRT1318457	hsa-miR-4465	CLIP-seq
MIRT2690033	hsa-miR-4520a-3p	CLIP-seq
MIRT2690034	hsa-miR-4638-3p	CLIP-seq
MIRT2094703	hsa-miR-4726-3p	CLIP-seq

30 Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	10644430
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004711	Function	Ribosomal protein S6 kinase activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IEA
GO:0007165	Process	Signal transduction	TAS	10644430
GO:0007417	Process	Central nervous system development	TAS	10644430
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030330	Process	DNA damage response, signal transduction by p53 class mediator	IBA
GO:0030330	Process	DNA damage response, signal transduction by p53 class mediator	IMP	15042092
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0038202	Process	TORC1 signaling	IBA
GO:0045992	Process	Negative regulation of embryonic development	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000381	Process	Negative regulation of mesoderm development	ISS

MIM	HGNC	e!Ensembl
300303	10435	ENSG00000072133

Q9UK32

Protein name

Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)

Protein function

Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. {ECO:0000

PDB

6G76 , 6G77 , 6G78

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00433	Pkinase_C	353 → 390	Protein kinase C terminal domain	Family
PF00069	Pkinase	426 → 683	Protein kinase domain	Domain
PF00069	Pkinase	73 → 330	Protein kinase domain	Domain

Sequence

MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH
VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT
KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA
ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM
APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA
QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF
DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA
QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI
ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV
HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD
AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL
SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ
PVLEPVAASSLAQRRSMKKRTSTGL

Sequence length

745

Interactions

View interactions

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Oocyte meiosis	RSK activation
mTOR signaling pathway
Thermogenesis
Long-term potentiation
Neurotrophin signaling pathway
Progesterone-mediated oocyte maturation
Insulin resistance
Yersinia infection
Chemical carcinogenesis - receptor activation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (43)
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	19584160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	21384559		★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign Neoplasm	Benign Neoplasm	BEFREE	26732474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast adenocarcinoma	Breast Adenocarcinoma	BEFREE	26397146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	24338215, 26397146, 27986634, 28731146, 29684350, 31413588, 31545499		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	27986634	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36498899	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	19584160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34034705	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	23942078	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	26732474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	19584160		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30579335		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25197367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30579335, 36498899	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	25625843	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Contiguous gene syndrome	Contiguous gene syndrome	BEFREE	10644430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	23942078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	22297070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	22297070	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	21372219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	21372219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31701625		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	33470396	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Large cell carcinoma of lung	Lung Carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36498899	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	24338215, 26397146, 27986634, 28731146, 29684350, 31413588, 31545499		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	21372219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	26732474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26397146, 30579335		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17314274, 18628456		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked	Mental retardation	BEFREE	10644430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked 1	Mental Retardation, X-Linked	BEFREE	10644430		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17314274, 19584160, 21372219, 22614021, 24338215, 26397146, 26732474, 29684350, 30579335, 31545499		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	BEFREE	15615695		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	31413588, 31545499		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	26732474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	25625843	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	22020623		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	19584160, 22020623, 23942078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36031631, 36498899	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34323415	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPS6KA1	[]	12	["MAPK signaling pathway","Oocyte meiosis","mTOR signaling pathway","Thermogenesis","Long-term potentiation","Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Insulin resistance","Yersinia infection","Chemical carcinogenesis - receptor activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","RSK activation"]	[]
RPS6KA2	[]	12	["MAPK signaling pathway","Oocyte meiosis","mTOR signaling pathway","Thermogenesis","Long-term potentiation","Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Insulin resistance","Yersinia infection","Chemical carcinogenesis - receptor activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","RSK activation"]	[]
RPS6KA3	[]	12	["MAPK signaling pathway","Oocyte meiosis","mTOR signaling pathway","Thermogenesis","Long-term potentiation","Neurotrophin signaling pathway","Progesterone-mediated oocyte maturation","Insulin resistance","Yersinia infection","Chemical carcinogenesis - receptor activation","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","RSK activation"]	[]
SPDYE12	[]	2	["Oocyte meiosis","Progesterone-mediated oocyte maturation"]	[]
SPDYE2B	[]	2	["Oocyte meiosis","Progesterone-mediated oocyte maturation"]	[]

RPS6KA6 (ribosomal protein S6 kinase A6)

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