Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6194
Gene name	Ribosomal protein S6
Gene symbol	RPS6
Synonyms (NCBI Gene)	S6eS6
Chromosome	9
Chromosome location	9p22.1
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic r

246 Show/Hide all (246)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003330	hsa-miR-15a-5p	Review	20026422
MIRT003326	hsa-miR-16-5p	Review	20026422
MIRT003326	hsa-miR-16-5p	Proteomics	18668040
MIRT051718	hsa-let-7d-5p	CLASH	23622248
MIRT048636	hsa-miR-99a-5p	CLASH	23622248
MIRT047174	hsa-miR-182-3p	CLASH	23622248
MIRT046422	hsa-miR-15b-5p	CLASH	23622248
MIRT039518	hsa-miR-652-3p	CLASH	23622248
MIRT037442	hsa-miR-744-5p	CLASH	23622248
MIRT052691	hsa-miR-1260b	CLASH	23622248
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT439727	hsa-miR-544a	HITS-CLIP	24374217
MIRT439727	hsa-miR-544a	HITS-CLIP	24374217
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT613798	hsa-miR-6765-3p	HITS-CLIP	23824327
MIRT613797	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT613796	hsa-miR-764	HITS-CLIP	23824327
MIRT613795	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT613794	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT613793	hsa-miR-4286	HITS-CLIP	23824327
MIRT613792	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT613791	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT613790	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT613789	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613788	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT613787	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT613786	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613785	hsa-miR-4312	HITS-CLIP	23824327
MIRT613784	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT613783	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT613782	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT613781	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT613780	hsa-miR-640	HITS-CLIP	23824327
MIRT613779	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT613778	hsa-miR-6878-3p	HITS-CLIP	23824327

53 Show/Hide all (53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IEA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	IDA	8706699, 34314702
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003729	Function	MRNA binding	IEA
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IDA	8706699, 23636399, 34314702
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0005515	Function	Protein binding	IPI	16314389, 18423201, 19417104, 21418524, 24454821, 26496610, 29568061, 30021884, 34232536, 34901782, 36217030
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	2334893
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	8590812
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	IEA
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	17220279
GO:0015935	Component	Small ribosomal subunit	IDA	15590835
GO:0016020	Component	Membrane	HDA	19946888
GO:0019901	Function	Protein kinase binding	IPI	21418524
GO:0022626	Component	Cytosolic ribosome	IDA	8706699
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	1301164, 25901680
GO:0030425	Component	Dendrite	IDA	15121898
GO:0031929	Process	TOR signaling	IDA	16428328
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032868	Process	Response to insulin	IEA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA	15121898
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	18697920
GO:0042593	Process	Glucose homeostasis	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	18362888
GO:0044297	Component	Cell body	IDA	15121898
GO:0071361	Process	Cellular response to ethanol	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:1903347	Process	Negative regulation of bicellular tight junction assembly	IEA
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
180460	10429	ENSG00000137154

P62753

Protein name

Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)

Protein function

Component of the 40S small ribosomal subunit (PubMed:23636399, PubMed:8706699). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:17220279). Part of the s

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6F4P , 6F4Q , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBW , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOK , 6ZON , 6ZP4 , 6ZUO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01092	Ribosomal_S6e	1 → 126	Ribosomal protein S6e	Family

Sequence

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQG
FPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKD
IPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLV
TPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRAS
TSKSESSQK

Sequence length

249

Interactions

View interactions

KEGG Pathway	Reactome Pathway
EGFR tyrosine kinase inhibitor resistance	L13a-mediated translational silencing of Ceruloplasmin expression
Ribosome	mTORC1-mediated signalling
HIF-1 signaling pathway	SRP-dependent cotranslational protein targeting to membrane
mTOR signaling pathway	Viral mRNA Translation
PI3K-Akt signaling pathway	Major pathway of rRNA processing in the nucleolus and cytosol
Apelin signaling pathway	Translation initiation complex formation
Thermogenesis	Formation of a pool of free 40S subunits
Insulin signaling pathway	Formation of the ternary complex, and subsequently, the 43S complex
Coronavirus disease - COVID-19	Ribosomal scanning and start codon recognition
Proteoglycans in cancer	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (9)
BREAST NEOPLASMS	—	CTD	20197467	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	21147110	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	30595370	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hemimegalencephaly	Uncertain significance	ClinVar Disgenet	—	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hepatocellular carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	21364753	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (115)
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	25199762		★★★★★ ★☆☆☆☆ Found in Text Mining only
Angiofibroma	Angiofibroma	BEFREE	24558502		★★★★★ ★☆☆☆☆ Found in Text Mining only
Angiomyolipoma of kidney	Angiomyolipoma Of Kidney	BEFREE	12547707		★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	29328863		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	30705255	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	30705255		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	28693262		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18652687, 29258115, 31252399, 31413588		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	20197467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28247844, 29258115	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	31096691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	21040950		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	24643969	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	32862831	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	26506236, 28713889	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	Pubtator	16779802	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chordoma	Chordoma	Pubtator	19401700	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coffin-Lowry syndrome	Coffin-Lowry Syndrome	BEFREE	17100996, 23985797, 26297997		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	31040906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	25379021		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25379021, 37475862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	26506236, 27387559		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	30225988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	22297070, 30225988		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	26549531	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	28701517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diarrhea 5 With Tufting Enteropathy Congenital	Congenital diarrhea	Pubtator	23015458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	21102526		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	22996377	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	22996377	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fleck corneal dystrophy	Fleck Corneal Dystrophy	BEFREE	26018084		★★★★★ ★☆☆☆☆ Found in Text Mining only
Focal cortical dysplasia of Taylor	Focal cortical dysplasia	Pubtator	20613634	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	28978054, 29328863, 30129426		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	29328863, 32246865, 34831193	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	23110505, 28978054, 30129426		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28978054		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	32246865, 34831193, 35287169	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangiosarcoma	Hemangiosarcoma	BEFREE	23938603		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemimegalencephaly	Hemimegalencephaly	BEFREE	31411685		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipoproteinemia Type II	Hyperlipoproteinemia	Pubtator	20613634	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	29494287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	31722741		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	19147540, 34200497	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Incontinentia Pigmenti Achromians	Incontinentia Pigmenti Achromians	BEFREE	28352194		★★★★★ ★☆☆☆☆ Found in Text Mining only
Infantile hemangioma	Hemangioma	BEFREE	23938603		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	23985797		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ki-1+ Anaplastic Large Cell Lymphoma	Anaplastic Lymphoma	BEFREE	24112608		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Neoplasm	Kidney Neoplasm	BEFREE	21907923		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	22094587		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	21067588, 29723246	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	21067588, 29723246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukoplakia, Oral	Leukoplakia	BEFREE	31498938		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	21147110		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	24643969		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	28701517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	28701517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	28701517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Vulgaris	Lupus Vulgaris	BEFREE	28701517		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphangioleiomyomatosis	Lymphangiomyomatosis	BEFREE	12045200		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	21102526		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	21102526		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18652687, 29258115, 31252399, 31413588		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	20197467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26080838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	31040906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30504425		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16247451, 19138981, 24859886, 28276898, 28481292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Peripheral Nerve Sheath Tumor	Malignant Peripheral Nerve Sheath Tumor	BEFREE	26695815		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31040906		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	20197467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	20197467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	20197467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	17148679		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	17914450, 29777202		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	25749517, 29777202	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	33082316	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	Pubtator	36115922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Motor Neuron Disease	Motor Neuron Disease	LHGDN	18642007		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	23015458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	23077530	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	24126065		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12045200, 16818631, 16915281, 18538015, 21890461, 27663511, 28247844, 28675642, 30129426, 31252399		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	25199762, 26490682		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32862831	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29451215		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pervasive Development Disorder	Autism spectrum disorder	BEFREE	30705255		★★★★★ ★☆☆☆☆ Found in Text Mining only
Post-Traumatic Stress Disorder	Stress Disorder	BEFREE	23856297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Proliferative vitreoretinopathy	Proliferative Vitreoretinopathy	BEFREE	29182404		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	26080838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	10554036		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	24885093, 26124442	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	26506236, 27387559		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	BEFREE	30442943		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	20959493		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	33564073	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	25199762, 28675642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	22996377		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	18538015, 23015458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	30339792		★★★★★ ★☆☆☆☆ Found in Text Mining only
Status Epilepticus	Status Epilepticus	BEFREE	28822838		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30504425		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Strawberry nevus of skin	Strawberry Nevus Of Skin	BEFREE	23938603		★★★★★ ★☆☆☆☆ Found in Text Mining only
Teratozoospermia	Teratozoospermia	Pubtator	29901159	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thymoma	Thymoma	BEFREE	30652078		★★★★★ ★☆☆☆☆ Found in Text Mining only
Trichohepatoenteric Syndrome	Trichohepatoenteric Syndrome	BEFREE	22009732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	25955731	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tuberous Sclerosis	Tuberous Sclerosis	LHGDN	15477556		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tuberous Sclerosis	Tuberous Sclerosis	BEFREE	24558502		★★★★★ ★☆☆☆☆ Found in Text Mining only
TUBEROUS SCLEROSIS 2 (disorder)	Tuberous Sclerosis	BEFREE	12045200		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	35896848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	27581326	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPS4Y2	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPSA	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPS27L	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPS3A	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPS4X	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]

RPS6 (ribosomal protein S6)

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