Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6193
Gene name	Ribosomal protein S5
Gene symbol	RPS5
Synonyms (NCBI Gene)	S5uS7
Chromosome	19
Chromosome location	19q13.43
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049510	hsa-miR-92a-3p	qRT-PCR	23622248
MIRT050401	hsa-miR-23a-3p	CLASH	23622248
MIRT049510	hsa-miR-92a-3p	CLASH	23622248
MIRT045846	hsa-miR-132-3p	CLASH	23622248
MIRT043015	hsa-miR-324-3p	CLASH	23622248
MIRT041103	hsa-miR-503-5p	CLASH	23622248
MIRT037868	hsa-miR-455-3p	CLASH	23622248
MIRT035988	hsa-miR-1301-3p	CLASH	23622248
MIRT726680	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726681	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726679	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726678	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1317996	hsa-miR-1207-3p	CLIP-seq
MIRT1317997	hsa-miR-3153	CLIP-seq
MIRT1317998	hsa-miR-3189-5p	CLIP-seq
MIRT1317999	hsa-miR-4436b-3p	CLIP-seq
MIRT1318000	hsa-miR-4646-5p	CLIP-seq
MIRT1318001	hsa-miR-4668-5p	CLIP-seq
MIRT1318002	hsa-miR-4758-3p	CLIP-seq
MIRT1318003	hsa-miR-646	CLIP-seq
MIRT1317996	hsa-miR-1207-3p	CLIP-seq
MIRT1317997	hsa-miR-3153	CLIP-seq
MIRT1318000	hsa-miR-4646-5p	CLIP-seq
MIRT1318001	hsa-miR-4668-5p	CLIP-seq
MIRT1318003	hsa-miR-646	CLIP-seq
MIRT1317996	hsa-miR-1207-3p	CLIP-seq
MIRT1317997	hsa-miR-3153	CLIP-seq
MIRT1317999	hsa-miR-4436b-3p	CLIP-seq
MIRT1318000	hsa-miR-4646-5p	CLIP-seq
MIRT1318001	hsa-miR-4668-5p	CLIP-seq
MIRT1318003	hsa-miR-646	CLIP-seq
MIRT2393886	hsa-miR-1913	CLIP-seq
MIRT1317998	hsa-miR-3189-5p	CLIP-seq
MIRT1317999	hsa-miR-4436b-3p	CLIP-seq
MIRT1318002	hsa-miR-4758-3p	CLIP-seq
MIRT1317996	hsa-miR-1207-3p	CLIP-seq
MIRT1317998	hsa-miR-3189-5p	CLIP-seq
MIRT1317999	hsa-miR-4436b-3p	CLIP-seq
MIRT1318002	hsa-miR-4758-3p	CLIP-seq
MIRT1318003	hsa-miR-646	CLIP-seq
MIRT1317996	hsa-miR-1207-3p	CLIP-seq
MIRT1317998	hsa-miR-3189-5p	CLIP-seq
MIRT1317999	hsa-miR-4436b-3p	CLIP-seq
MIRT1318002	hsa-miR-4758-3p	CLIP-seq
MIRT1318003	hsa-miR-646	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	NAS	7772601
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IDA	18464793
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005515	Function	Protein binding	IPI	24965446, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IBA
GO:0005840	Component	Ribosome	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IC	8706699
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	IGI	17901157
GO:0006412	Process	Translation	NAS	7772601
GO:0006413	Process	Translational initiation	IC	15883184
GO:0006450	Process	Regulation of translational fidelity	IGI	17901157
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019843	Function	RRNA binding	IBA
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
603630	10426	ENSG00000083845

P46782

Protein name

Small ribosomal subunit protein uS7 (40S ribosomal protein S5) [Cleaved into: Small ribosomal subunit protein uS7, N-terminally processed (40S ribosomal protein S5, N-terminally processed)]

Protein function

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of

PDB

4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00177	Ribosomal_S7	51 → 204	Ribosomal protein S7p/S5e	Domain

Sequence

MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKR
FRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSG
PREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINA
AKGSSNSYAIKKKDELERVAKSNR

Sequence length

204

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Translation initiation complex formation
	Formation of a pool of free 40S subunits
	Formation of the ternary complex, and subsequently, the 43S complex
	Ribosomal scanning and start codon recognition
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
RPS4Y2	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPSA	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPS27L	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPS3A	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]
RPS4X	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	[]

RPS5 (ribosomal protein S5)

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