RPS25 (ribosomal protein S25)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6230
• Gene name: Ribosomal protein S25
• Gene symbol: RPS25
• Synonyms (NCBI Gene): S25, eS25
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA Show/Hide all (19)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031942	hsa-miR-16-5p	Proteomics	18668040
MIRT049009	hsa-miR-92a-3p	CLASH	23622248
MIRT046991	hsa-miR-218-5p	CLASH	23622248
MIRT1317914	hsa-miR-1207-3p	CLIP-seq
MIRT1317915	hsa-miR-142-5p	CLIP-seq
MIRT1317916	hsa-miR-4535	CLIP-seq
MIRT1317917	hsa-miR-4776-5p	CLIP-seq
MIRT1317918	hsa-miR-492	CLIP-seq
MIRT1317919	hsa-miR-561	CLIP-seq
MIRT1317914	hsa-miR-1207-3p	CLIP-seq
MIRT1317915	hsa-miR-142-5p	CLIP-seq
MIRT1317916	hsa-miR-4535	CLIP-seq
MIRT1317917	hsa-miR-4776-5p	CLIP-seq
MIRT1317918	hsa-miR-492	CLIP-seq
MIRT1317919	hsa-miR-561	CLIP-seq
MIRT1317914	hsa-miR-1207-3p	CLIP-seq
MIRT1317916	hsa-miR-4535	CLIP-seq
MIRT1317917	hsa-miR-4776-5p	CLIP-seq
MIRT1317918	hsa-miR-492	CLIP-seq

Gene ontology (GO) Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	NAS	10050887
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0005515	Function	Protein binding	IPI	22720776, 24965446, 25416956, 32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	22720776
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	10050887
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IDA	1748303
GO:0005840	Component	Ribosome	IEA
GO:0005840	Component	Ribosome	NAS	8020948
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	IC	8706699, 15883184
GO:0006412	Process	Translation	NAS	8020948
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0015935	Component	Small ribosomal subunit	HDA	15883184
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022626	Component	Cytosolic ribosome	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	HDA	15883184
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	18697920
GO:0045202	Component	Synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 180465
• HGNC: 10413
• e!Ensembl: ENSG00000118181

Protein

• UniProt ID: P62851
• Protein name: Small ribosomal subunit protein eS25 (40S ribosomal protein S25)
• Protein function: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399).
• PDB: 4UG0 , 4V6X , 5A2Q , 5AJ0 , 5FLX , 5LKS , 5OA3 , 5T2C , 5VYC , 6FEC , 6G18 , 6G4S , 6G4W , 6G51 , 6G53 , 6G5H , 6G5I , 6IP5 , 6IP6 , 6IP8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6YBS , 6Z6L , 6Z6M , 6Z6N , 6ZLW , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 6ZMT , 6ZMW , 6ZN5 , 6ZOJ , 6ZOL , 6ZON , 6ZP4 , 6ZUO , 6ZV6 , 6ZVH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03297	Ribosomal_S25	4 → 112	S25 ribosomal protein	Family

• Sequence:

  MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCK
  EVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPA
  AGEDA

• Sequence length: 125

Pathways

KEGG Pathway	Reactome Pathway
Ribosome	L13a-mediated translational silencing of Ceruloplasmin expression
Coronavirus disease - COVID-19	SRP-dependent cotranslational protein targeting to membrane
	Viral mRNA Translation
	Major pathway of rRNA processing in the nucleolus and cytosol
	Translation initiation complex formation
	Formation of a pool of free 40S subunits
	Formation of the ternary complex, and subsequently, the 43S complex
	Ribosomal scanning and start codon recognition
	GTP hydrolysis and joining of the 60S ribosomal subunit
	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Genes

Sort by: Blended Diseases Pathways Evidence source

RPS4Y2 13 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Translation initiation complex formation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, Ribosomal scanning and start codon recognition, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation +1 more Related via 13 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPSA 13 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Translation initiation complex formation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, Ribosomal scanning and start codon recognition, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation +1 more Related via 13 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPS27L 13 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Translation initiation complex formation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, Ribosomal scanning and start codon recognition, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation +1 more Related via 13 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPS3A 13 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Translation initiation complex formation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, Ribosomal scanning and start codon recognition, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation +1 more Related via 13 shared pathways including Ribosome, Coronavirus disease - COVID-19. RPS4X 13 shared pathwaysRibosome, Coronavirus disease - COVID-19, Major pathway of rRNA processing in the nucleolus and cytosol, L13a-mediated translational silencing of Ceruloplasmin expression, Translation initiation complex formation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, Ribosomal scanning and start codon recognition, GTP hydrolysis and joining of the 60S ribosomal subunit, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), SRP-dependent cotranslational protein targeting to membrane, Viral mRNA Translation +1 more Related via 13 shared pathways including Ribosome, Coronavirus disease - COVID-19.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RPS4Y2	0	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	0	[]
RPSA	0	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	0	[]
RPS27L	0	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	0	[]
RPS3A	0	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	0	[]
RPS4X	0	[]	13	["Ribosome","Coronavirus disease - COVID-19","Major pathway of rRNA processing in the nucleolus and cytosol","L13a-mediated translational silencing of Ceruloplasmin expression","Translation initiation complex formation","Formation of a pool of free 40S subunits","Formation of the ternary complex, and subsequently, the 43S complex","Ribosomal scanning and start codon recognition","GTP hydrolysis and joining of the 60S ribosomal subunit","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","SRP-dependent cotranslational protein targeting to membrane","Viral mRNA Translation"]	0	[]

Diseases Linked via Similar Genes

Spermatogenic failure, y-linked Linked via 1 of 5 related genesRPS4Y2 Asplenia Linked via 1 of 5 related genesRPSA Congenital asplenia Linked via 1 of 5 related genesRPSA Frontotemporal dementia Linked via 1 of 5 related genesRPSA Schizophrenia Linked via 1 of 5 related genesRPSA

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Spermatogenic failure, y-linked	1	["RPS4Y2"]
Asplenia	1	["RPSA"]
Congenital asplenia	1	["RPSA"]
Frontotemporal dementia	1	["RPSA"]
Schizophrenia	1	["RPSA"]