Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)
Protein function
As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activ
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["DNA replication","Nucleotide excision repair","Mismatch repair","Homologous recombination","Fanconi anemia pathway","HSF1 activation","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Regulation of HSF1-mediated heat shock response","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Single Strand Annealing (SSA)"]
["DNA replication","Nucleotide excision repair","Mismatch repair","Homologous recombination","Fanconi anemia pathway","HSF1 activation","Formation of Incision Complex in GG-NER","Dual Incision in GG-NER","Regulation of HSF1-mediated heat shock response","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Single Strand Annealing (SSA)"]
["DNA replication","Nucleotide excision repair","Mismatch repair","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
["DNA replication","Nucleotide excision repair","Mismatch repair","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
["DNA replication","Nucleotide excision repair","Mismatch repair","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to RPA3 (see Related Genes above), that are NOT already directly curated for RPA3 itself -- a lead worth checking, not a confirmed association.