RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM, Mar 2008]
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75)
Protein function
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and h
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
CausalDiseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["Fanconi anemia pathway","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)","Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous DNA Pairing and Strand Exchange","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
["Fanconi anemia pathway","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)","Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous DNA Pairing and Strand Exchange","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
["Fanconi anemia pathway","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)","Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous DNA Pairing and Strand Exchange","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
["Fanconi anemia pathway","HDR through Single Strand Annealing (SSA)","HDR through Homologous Recombination (HRR)","Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)","Resolution of D-loop Structures through Holliday Junction Intermediates","Homologous DNA Pairing and Strand Exchange","Processing of DNA double-strand break ends","Presynaptic phase of homologous DNA pairing and strand exchange","Regulation of TP53 Activity through Phosphorylation","G2\/M DNA damage checkpoint"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to RMI1 (see Related Genes above), that are NOT already directly curated for RMI1 itself -- a lead worth checking, not a confirmed association.