Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	83732
Gene name	RIO kinase 1
Gene symbol	RIOK1
Synonyms (NCBI Gene)	AD034RIO1RRP10bA288G3.1
Chromosome	6
Chromosome location	6p24.3
Summary	The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunit

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049170	hsa-miR-92a-3p	CLASH	23622248
MIRT1307412	hsa-miR-1227	CLIP-seq
MIRT1307413	hsa-miR-1324	CLIP-seq
MIRT1307414	hsa-miR-204	CLIP-seq
MIRT1307415	hsa-miR-211	CLIP-seq
MIRT1307416	hsa-miR-2115	CLIP-seq
MIRT1307417	hsa-miR-2681	CLIP-seq
MIRT1307418	hsa-miR-27a	CLIP-seq
MIRT1307419	hsa-miR-27b	CLIP-seq
MIRT1307420	hsa-miR-3938	CLIP-seq
MIRT1307421	hsa-miR-410	CLIP-seq
MIRT1307422	hsa-miR-412	CLIP-seq
MIRT1307423	hsa-miR-4729	CLIP-seq
MIRT1307424	hsa-miR-4755-5p	CLIP-seq
MIRT1307425	hsa-miR-4800-3p	CLIP-seq
MIRT1307426	hsa-miR-513a-5p	CLIP-seq
MIRT1307427	hsa-miR-516a-3p	CLIP-seq
MIRT1307428	hsa-miR-548aa	CLIP-seq
MIRT1307429	hsa-miR-623	CLIP-seq
MIRT1307430	hsa-miR-1243	CLIP-seq
MIRT1307431	hsa-miR-1301	CLIP-seq
MIRT1307413	hsa-miR-1324	CLIP-seq
MIRT1307432	hsa-miR-134	CLIP-seq
MIRT1307433	hsa-miR-3118	CLIP-seq
MIRT1307434	hsa-miR-3180-5p	CLIP-seq
MIRT1307435	hsa-miR-3591-3p	CLIP-seq
MIRT1307436	hsa-miR-3937	CLIP-seq
MIRT1307437	hsa-miR-4276	CLIP-seq
MIRT1307438	hsa-miR-4305	CLIP-seq
MIRT1307439	hsa-miR-4660	CLIP-seq
MIRT1307440	hsa-miR-4697-3p	CLIP-seq
MIRT1307441	hsa-miR-4720-3p	CLIP-seq
MIRT1307442	hsa-miR-4797-5p	CLIP-seq
MIRT1307443	hsa-miR-5047	CLIP-seq
MIRT1307444	hsa-miR-518d-5p	CLIP-seq
MIRT1307445	hsa-miR-519b-5p	CLIP-seq
MIRT1307446	hsa-miR-519c-5p	CLIP-seq
MIRT1307447	hsa-miR-520a-5p	CLIP-seq
MIRT1307448	hsa-miR-520c-5p	CLIP-seq
MIRT1307449	hsa-miR-525-5p	CLIP-seq
MIRT1307450	hsa-miR-526a	CLIP-seq
MIRT1307412	hsa-miR-1227	CLIP-seq
MIRT1307430	hsa-miR-1243	CLIP-seq
MIRT1307413	hsa-miR-1324	CLIP-seq
MIRT1307432	hsa-miR-134	CLIP-seq
MIRT1307418	hsa-miR-27a	CLIP-seq
MIRT1307419	hsa-miR-27b	CLIP-seq
MIRT1307433	hsa-miR-3118	CLIP-seq
MIRT1307435	hsa-miR-3591-3p	CLIP-seq
MIRT1307422	hsa-miR-412	CLIP-seq
MIRT1307437	hsa-miR-4276	CLIP-seq
MIRT1307438	hsa-miR-4305	CLIP-seq
MIRT1307440	hsa-miR-4697-3p	CLIP-seq
MIRT1307442	hsa-miR-4797-5p	CLIP-seq
MIRT1307425	hsa-miR-4800-3p	CLIP-seq
MIRT1307426	hsa-miR-513a-5p	CLIP-seq
MIRT1307431	hsa-miR-1301	CLIP-seq
MIRT1307434	hsa-miR-3180-5p	CLIP-seq
MIRT2611897	hsa-miR-376c	CLIP-seq
MIRT1307436	hsa-miR-3937	CLIP-seq
MIRT1307438	hsa-miR-4305	CLIP-seq
MIRT1307439	hsa-miR-4660	CLIP-seq
MIRT2611898	hsa-miR-4666-5p	CLIP-seq
MIRT1307441	hsa-miR-4720-3p	CLIP-seq
MIRT1307443	hsa-miR-5047	CLIP-seq
MIRT1307444	hsa-miR-518d-5p	CLIP-seq
MIRT1307445	hsa-miR-519b-5p	CLIP-seq
MIRT1307446	hsa-miR-519c-5p	CLIP-seq
MIRT1307447	hsa-miR-520a-5p	CLIP-seq
MIRT1307448	hsa-miR-520c-5p	CLIP-seq
MIRT1307449	hsa-miR-525-5p	CLIP-seq
MIRT1307450	hsa-miR-526a	CLIP-seq
MIRT1307428	hsa-miR-548aa	CLIP-seq
MIRT2611899	hsa-miR-570	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	21081503, 25852190, 32707033, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	21081503
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030490	Process	Maturation of SSU-rRNA	IBA
GO:0030490	Process	Maturation of SSU-rRNA	IMP	22072790
GO:0030688	Component	Preribosome, small subunit precursor	IBA
GO:0030688	Component	Preribosome, small subunit precursor	IDA	22072790
GO:0034708	Component	Methyltransferase complex	IMP	21081503
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	22072790
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000234	Process	Positive regulation of rRNA processing	IMP	22072790

MIM	HGNC	e!Ensembl
617753	18656	ENSG00000124784

Q9BRS2

Protein name

Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.1.-) (RIO kinase 1)

Protein function

Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The a

PDB

4OTP , 6G5I , 6V0N , 6ZV6 , 6ZXD , 6ZXE , 6ZXF , 6ZXG , 6ZXH , 7BOC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01163	RIO1	193 → 381		Family

Sequence

MDYRRLLMSRVVPGQFDDADSSDSENRDLKTVKEKDDILFEDLQDNVNENGEGEIEDEEE
EGYDDDDDDWDWDEGVGKLAKGYVWNGGSNPQANRQTSDSSSAKMSTPADKVLRKFENKI
NLDKLNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIIT
EINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPR
KMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKA
RELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKD
CANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHV
DEEVFKRAYIPRTLNEVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDLSGVQ
KVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHARPKKHTTDPDIDKKERKKMVKE
AQREKRKNKIPKHVKKRKEKTAKTKKGK

Sequence length

568

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome biogenesis in eukaryotes	Major pathway of rRNA processing in the nucleolus and cytosol

RIOK1 (RIO kinase 1)

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