RBP2 (retinol binding protein 2)

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Gene Gene information from NCBI Gene database.
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Entrez ID 5948
Gene name Retinol binding protein 2
Gene symbol RBP2
Synonyms (NCBI Gene)
CRABP-IICRBP2CRBPIIRBPC2
Chromosome 3
Chromosome location 3q23
Summary This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiati
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT053351 hsa-miR-212-3p Luciferase reporter assayqRT-PCRWestern blot 23922798
MIRT053351 hsa-miR-212-3p Luciferase reporter assayqRT-PCRWestern blot 23922798
MIRT053351 hsa-miR-212-3p Luciferase reporter assayqRT-PCRWestern blot 23922798
MIRT053351 hsa-miR-212-3p Luciferase reporter assayqRT-PCRWestern blot 23922798
MIRT053351 hsa-miR-212-3p ImmunohistochemistryqRT-PCRWestern blot 23794145
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0001523 Process Retinoid metabolic process IEA
GO:0005501 Function Retinoid binding TAS 7657783
GO:0005504 Function Fatty acid binding IBA
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
180280 9920 ENSG00000114113
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P50120
Protein name Retinol-binding protein 2 (Cellular retinol-binding protein II) (CRBP-II)
Protein function Intracellular transport of retinol.
PDB 2RCQ , 2RCT , 4EDE , 4EEJ , 4EFG , 4EXZ , 4GKC , 4QYN , 4QYP , 4QZT , 4QZU , 4RUU , 4ZCB , 4ZGU , 4ZH6 , 4ZH9 , 4ZJ0 , 4ZR2 , 5DG4 , 5DPQ , 5F58 , 5F6B , 5F7G , 5FAZ , 5FEN , 5FFH , 5U6G , 6BTH , 6BTI , 6C7Z , 6E50 , 6E51 , 6E5E , 6E5Q , 6E5R , 6E5S , 6E6L , 6E7M , 6MCU , 6MCV , 6MKV , 6MLB , 6ON5 , 6ON7 , 6ON8 , 6VID , 6VIS , 6VIT , 6WNF , 6WNJ , 6WP0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 6 → 134 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Higher expression in adult small intestine and to a much lesser extent in fetal kidney. {ECO:0000269|PubMed:11274389}.
Sequence 
MTRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKVIDQDGDNFKTKTTSTFRN
YDVDFTVGVEFDEYTKSLDNRHVKALVTWEGDVLVCVQKGEKENRGWKQWIEGDKLYLEL
TCGDQVCRQVFKKK
Sequence length 134
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Vitamin digestion and absorption Retinoid metabolism and transport
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LRAT 2 shared pathwaysVitamin digestion and absorption, Retinoid metabolism and transport Related via 2 shared pathways including Vitamin digestion and absorption, Retinoid metabolism and transport. PNLIP 2 shared pathwaysVitamin digestion and absorption, Retinoid metabolism and transport Related via 2 shared pathways including Vitamin digestion and absorption, Retinoid metabolism and transport. PLB1 2 shared pathwaysVitamin digestion and absorption, Retinoid metabolism and transport Related via 2 shared pathways including Vitamin digestion and absorption, Retinoid metabolism and transport. APOA1 2 shared pathwaysVitamin digestion and absorption, Retinoid metabolism and transport Related via 2 shared pathways including Vitamin digestion and absorption, Retinoid metabolism and transport. APOB 2 shared pathwaysVitamin digestion and absorption, Retinoid metabolism and transport Related via 2 shared pathways including Vitamin digestion and absorption, Retinoid metabolism and transport.
Alzheimer disease Linked via 3 of 5 related genesLRAT, APOA1, APOB Stroke Linked via 3 of 5 related genesLRAT, APOA1, APOB Diabetes mellitus type 2 Linked via 3 of 5 related genesPLB1, APOA1, APOB Hepatocellular carcinoma Linked via 2 of 5 related genesLRAT, APOA1 Celiac disease Linked via 2 of 5 related genesLRAT, APOB