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Gene Gene information from NCBI Gene database.
Entrez ID 5928
Gene name RB binding protein 4, chromatin remodeling factor
Gene symbol RBBP4
Synonyms (NCBI Gene)
NURF55RBAP48lin-53
Chromosome 1
Chromosome location 1p35.1
Summary This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which
miRNA miRNA information provided by mirtarbase database.
1206 Show/Hide all (1206)
miRTarBase ID miRNA Experiments Reference
MIRT051653 hsa-let-7e-5p CLASH 23622248
MIRT043073 hsa-miR-324-5p CLASH 23622248
MIRT042541 hsa-miR-423-3p CLASH 23622248
MIRT040854 hsa-miR-18a-3p CLASH 23622248
MIRT054559 hsa-miR-429 ChIP-seqFlowImmunohistochemistryIn situ hybridizationLuciferase reporter assayMicroarrayqRT-PCRWestern blot 24572141
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
59 Show/Hide all (59)
GO ID Ontology Definition Evidence Reference
GO:0000118 Component Histone deacetylase complex IDA 9651585
GO:0000122 Process Negative regulation of transcription by RNA polymerase II NAS 9651585, 22865885
GO:0000781 Component Chromosome, telomeric region IDA 30045876
GO:0000781 Component Chromosome, telomeric region IEA
GO:0000785 Component Chromatin HDA 16217013
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602923 9887 ENSG00000162521
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q09028
Protein name Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4)
Protein function Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chrom
PDB 2XU7 , 3GFC , 4PBY , 4PBZ , 4PC0 , 4R7A , 5FXY , 5VTB , 5WAI , 5WAK , 5XWR , 5XXQ , 5Y1U , 6BW3 , 6BW4 , 6C23 , 6C24 , 6G16 , 6NQ3 , 6WKR , 6ZRC , 6ZRD , 7AOA , 7KSO , 7KSR , 7KTP , 7M40 , 7N40 , 7R1D , 7Y5K , 7Y5L , 7Y5O , 7Y5U , 7Y5V , 8EQV , 8FYH , 8IQF , 8IQG , 8T9G , 8TAS , 8TB9 , 8TX8 , 8VMI , 8VML , 8VNV , 8VNZ , 9C8U , 9DCH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 263 → 302 WD domain, G-beta repeat Repeat
PF00400 WD40 308 → 346 WD domain, G-beta repeat Repeat
PF00400 WD40 364 → 403 WD domain, G-beta repeat Repeat
PF00400 WD40 167 → 206 WD domain, G-beta repeat Repeat
PF00400 WD40 218 → 256 WD domain, G-beta repeat Repeat
PF12265 CAF1C_H4-bd 19 → 88 Histone-binding protein RBBP4 or subunit C of CAF1 complex Family
Tissue specificity TISSUE SPECIFICITY: Expressed in neuroblastoma cells. {ECO:0000269|PubMed:30026490}.
Sequence
Sequence length 425
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
ATP-dependent chromatin remodeling Transcription of E2F targets under negative control by DREAM complex
Polycomb repressive complex G0 and Early G1
Cellular senescence Polo-like kinase mediated events
  PRC2 methylates histones and DNA
  Oxidative Stress Induced Senescence
  HDACs deacetylate histones
  PKMTs methylate histone lysines
  Deposition of new CENPA-containing nucleosomes at the centromere
  Regulation of TP53 Activity through Acetylation
  Cyclin E associated events during G1/S transition
  G1/S-Specific Transcription
  Cyclin A:Cdk2-associated events at S phase entry
  RNA Polymerase I Transcription Initiation
  Regulation of PTEN gene transcription
  Transcriptional Regulation by E2F6
  HCMV Early Events