RAB6B (RAB6B, member RAS oncogene family)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51560
• Gene name: RAB6B, member RAS oncogene family
• Gene symbol: RAB6B
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q22.1

miRNA Show/Hide all (189)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003086	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT724221	hsa-miR-6771-3p	HITS-CLIP	19536157
MIRT724220	hsa-miR-3914	HITS-CLIP	19536157
MIRT724219	hsa-miR-3140-5p	HITS-CLIP	19536157
MIRT724218	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT724217	hsa-miR-1252-5p	HITS-CLIP	19536157
MIRT442352	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442351	hsa-miR-4254	PAR-CLIP	22100165
MIRT442350	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442349	hsa-miR-4510	PAR-CLIP	22100165
MIRT442348	hsa-miR-6127	PAR-CLIP	22100165
MIRT442347	hsa-miR-6129	PAR-CLIP	22100165
MIRT442346	hsa-miR-6130	PAR-CLIP	22100165
MIRT442345	hsa-miR-6133	PAR-CLIP	22100165
MIRT442344	hsa-miR-1254	PAR-CLIP	22100165
MIRT442343	hsa-miR-3116	PAR-CLIP	22100165
MIRT442342	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT442341	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT442339	hsa-miR-6731-5p	PAR-CLIP	22100165
MIRT442340	hsa-miR-8085	PAR-CLIP	22100165
MIRT442338	hsa-miR-6515-5p	PAR-CLIP	22100165
MIRT442352	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442351	hsa-miR-4254	PAR-CLIP	22100165
MIRT442350	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442349	hsa-miR-4510	PAR-CLIP	22100165
MIRT442348	hsa-miR-6127	PAR-CLIP	22100165
MIRT442347	hsa-miR-6129	PAR-CLIP	22100165
MIRT442346	hsa-miR-6130	PAR-CLIP	22100165
MIRT442345	hsa-miR-6133	PAR-CLIP	22100165
MIRT442344	hsa-miR-1254	PAR-CLIP	22100165
MIRT442343	hsa-miR-3116	PAR-CLIP	22100165
MIRT442342	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT442341	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT442339	hsa-miR-6731-5p	PAR-CLIP	22100165
MIRT442340	hsa-miR-8085	PAR-CLIP	22100165
MIRT442338	hsa-miR-6515-5p	PAR-CLIP	22100165
MIRT724221	hsa-miR-6771-3p	HITS-CLIP	19536157
MIRT724220	hsa-miR-3914	HITS-CLIP	19536157
MIRT724219	hsa-miR-3140-5p	HITS-CLIP	19536157
MIRT724218	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT724217	hsa-miR-1252-5p	HITS-CLIP	19536157
MIRT442352	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442351	hsa-miR-4254	PAR-CLIP	22100165
MIRT442350	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442349	hsa-miR-4510	PAR-CLIP	22100165
MIRT442348	hsa-miR-6127	PAR-CLIP	22100165
MIRT442347	hsa-miR-6129	PAR-CLIP	22100165
MIRT442346	hsa-miR-6130	PAR-CLIP	22100165
MIRT442345	hsa-miR-6133	PAR-CLIP	22100165
MIRT442344	hsa-miR-1254	PAR-CLIP	22100165
MIRT442343	hsa-miR-3116	PAR-CLIP	22100165
MIRT442342	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT442341	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT442339	hsa-miR-6731-5p	PAR-CLIP	22100165
MIRT442340	hsa-miR-8085	PAR-CLIP	22100165
MIRT442338	hsa-miR-6515-5p	PAR-CLIP	22100165
MIRT442352	hsa-miR-6760-5p	PAR-CLIP	22100165
MIRT442351	hsa-miR-4254	PAR-CLIP	22100165
MIRT442350	hsa-miR-4419a	PAR-CLIP	22100165
MIRT442349	hsa-miR-4510	PAR-CLIP	22100165
MIRT442348	hsa-miR-6127	PAR-CLIP	22100165
MIRT442347	hsa-miR-6129	PAR-CLIP	22100165
MIRT442346	hsa-miR-6130	PAR-CLIP	22100165
MIRT442345	hsa-miR-6133	PAR-CLIP	22100165
MIRT442344	hsa-miR-1254	PAR-CLIP	22100165
MIRT442343	hsa-miR-3116	PAR-CLIP	22100165
MIRT442342	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT442341	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT442339	hsa-miR-6731-5p	PAR-CLIP	22100165
MIRT442340	hsa-miR-8085	PAR-CLIP	22100165
MIRT442338	hsa-miR-6515-5p	PAR-CLIP	22100165
MIRT1285498	hsa-miR-142-5p	CLIP-seq
MIRT1285499	hsa-miR-183	CLIP-seq
MIRT1285500	hsa-miR-2277-3p	CLIP-seq
MIRT1285501	hsa-miR-2392	CLIP-seq
MIRT1285502	hsa-miR-23a	CLIP-seq
MIRT1285503	hsa-miR-23b	CLIP-seq
MIRT1285504	hsa-miR-23c	CLIP-seq
MIRT1285505	hsa-miR-3121-3p	CLIP-seq
MIRT1285506	hsa-miR-3136-3p	CLIP-seq
MIRT1285507	hsa-miR-3138	CLIP-seq
MIRT1285508	hsa-miR-3175	CLIP-seq
MIRT1285509	hsa-miR-3177-5p	CLIP-seq
MIRT1285510	hsa-miR-3194-3p	CLIP-seq
MIRT1285511	hsa-miR-328	CLIP-seq
MIRT1285512	hsa-miR-329	CLIP-seq
MIRT1285513	hsa-miR-338-5p	CLIP-seq
MIRT1285514	hsa-miR-362-3p	CLIP-seq
MIRT1285515	hsa-miR-377	CLIP-seq
MIRT1285516	hsa-miR-382	CLIP-seq
MIRT1285517	hsa-miR-3913-3p	CLIP-seq
MIRT1285518	hsa-miR-3977	CLIP-seq
MIRT1285519	hsa-miR-4434	CLIP-seq
MIRT1285520	hsa-miR-4459	CLIP-seq
MIRT1285521	hsa-miR-4476	CLIP-seq
MIRT1285522	hsa-miR-4504	CLIP-seq
MIRT1285523	hsa-miR-4516	CLIP-seq
MIRT1285524	hsa-miR-4643	CLIP-seq
MIRT1285525	hsa-miR-4645-5p	CLIP-seq
MIRT1285526	hsa-miR-466	CLIP-seq
MIRT1285527	hsa-miR-4673	CLIP-seq
MIRT1285528	hsa-miR-4682	CLIP-seq
MIRT1285529	hsa-miR-4789-3p	CLIP-seq
MIRT1285530	hsa-miR-4789-5p	CLIP-seq
MIRT1285531	hsa-miR-4795-5p	CLIP-seq
MIRT1285532	hsa-miR-489	CLIP-seq
MIRT1285533	hsa-miR-499-3p	CLIP-seq
MIRT1285534	hsa-miR-499a-3p	CLIP-seq
MIRT1285535	hsa-miR-513a-3p	CLIP-seq
MIRT1285536	hsa-miR-542-3p	CLIP-seq
MIRT1285537	hsa-miR-548a-5p	CLIP-seq
MIRT1285538	hsa-miR-548ab	CLIP-seq
MIRT1285539	hsa-miR-548ak	CLIP-seq
MIRT1285540	hsa-miR-548b-5p	CLIP-seq
MIRT1285541	hsa-miR-548c-5p	CLIP-seq
MIRT1285542	hsa-miR-548d-5p	CLIP-seq
MIRT1285543	hsa-miR-548h	CLIP-seq
MIRT1285544	hsa-miR-548i	CLIP-seq
MIRT1285545	hsa-miR-548j	CLIP-seq
MIRT1285546	hsa-miR-548k	CLIP-seq
MIRT1285547	hsa-miR-548l	CLIP-seq
MIRT1285548	hsa-miR-548w	CLIP-seq
MIRT1285549	hsa-miR-548y	CLIP-seq
MIRT1285550	hsa-miR-559	CLIP-seq
MIRT1285551	hsa-miR-568	CLIP-seq
MIRT1285552	hsa-miR-603	CLIP-seq
MIRT1285553	hsa-miR-656	CLIP-seq
MIRT1285554	hsa-miR-665	CLIP-seq
MIRT1285555	hsa-miR-758	CLIP-seq
MIRT1556922	hsa-miR-1281	CLIP-seq
MIRT2084685	hsa-miR-1265	CLIP-seq
MIRT1556922	hsa-miR-1281	CLIP-seq
MIRT2084686	hsa-miR-1286	CLIP-seq
MIRT2084687	hsa-miR-3127-5p	CLIP-seq
MIRT2084688	hsa-miR-3605-5p	CLIP-seq
MIRT2084689	hsa-miR-4307	CLIP-seq
MIRT2084690	hsa-miR-4311	CLIP-seq
MIRT2084691	hsa-miR-4436b-3p	CLIP-seq
MIRT1285521	hsa-miR-4476	CLIP-seq
MIRT2084692	hsa-miR-4667-5p	CLIP-seq
MIRT2084693	hsa-miR-4700-5p	CLIP-seq
MIRT2084694	hsa-miR-4728-3p	CLIP-seq
MIRT2084695	hsa-miR-627	CLIP-seq
MIRT2084696	hsa-miR-924	CLIP-seq
MIRT2310024	hsa-miR-122	CLIP-seq
MIRT2310025	hsa-miR-2278	CLIP-seq
MIRT1285501	hsa-miR-2392	CLIP-seq
MIRT2310026	hsa-miR-3176	CLIP-seq
MIRT2310027	hsa-miR-3187-3p	CLIP-seq
MIRT2310028	hsa-miR-3202	CLIP-seq
MIRT2310029	hsa-miR-3688-3p	CLIP-seq
MIRT2310030	hsa-miR-3922-3p	CLIP-seq
MIRT2310031	hsa-miR-3978	CLIP-seq
MIRT2310032	hsa-miR-4266	CLIP-seq
MIRT1285521	hsa-miR-4476	CLIP-seq
MIRT2310033	hsa-miR-4492	CLIP-seq
MIRT2310034	hsa-miR-4498	CLIP-seq
MIRT2310035	hsa-miR-4505	CLIP-seq
MIRT2310036	hsa-miR-4529-5p	CLIP-seq
MIRT2310037	hsa-miR-4533	CLIP-seq
MIRT2084692	hsa-miR-4667-5p	CLIP-seq
MIRT2310038	hsa-miR-4691-3p	CLIP-seq
MIRT2084693	hsa-miR-4700-5p	CLIP-seq
MIRT2310039	hsa-miR-4717-5p	CLIP-seq
MIRT2310040	hsa-miR-4731-5p	CLIP-seq
MIRT2310041	hsa-miR-4747-5p	CLIP-seq
MIRT2310042	hsa-miR-4761-5p	CLIP-seq
MIRT2310043	hsa-miR-4786-3p	CLIP-seq
MIRT2310044	hsa-miR-503	CLIP-seq
MIRT2310045	hsa-miR-671-5p	CLIP-seq
MIRT2310046	hsa-miR-762	CLIP-seq
MIRT2393359	hsa-miR-3153	CLIP-seq
MIRT2393360	hsa-miR-3184	CLIP-seq
MIRT2393361	hsa-miR-423-5p	CLIP-seq
MIRT2393362	hsa-miR-4710	CLIP-seq
MIRT2393363	hsa-miR-4794	CLIP-seq
MIRT2439809	hsa-miR-335	CLIP-seq
MIRT2439810	hsa-miR-3663-3p	CLIP-seq
MIRT1285517	hsa-miR-3913-3p	CLIP-seq
MIRT2439811	hsa-miR-4778-3p	CLIP-seq
MIRT1285532	hsa-miR-489	CLIP-seq
MIRT2606491	hsa-miR-1200	CLIP-seq
MIRT2606492	hsa-miR-4502	CLIP-seq
MIRT2310040	hsa-miR-4731-5p	CLIP-seq
MIRT1285552	hsa-miR-603	CLIP-seq
MIRT2606491	hsa-miR-1200	CLIP-seq
MIRT2606492	hsa-miR-4502	CLIP-seq
MIRT2310040	hsa-miR-4731-5p	CLIP-seq
MIRT1285552	hsa-miR-603	CLIP-seq

Gene ontology (GO) Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	25492866
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	NAS	10893188
GO:0005515	Function	Protein binding	IPI	23737971, 27107012, 32296183
GO:0005525	Function	GTP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	NAS	10893188
GO:0005829	Component	Cytosol	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	NAS	10893188
GO:0006891	Process	Intra-Golgi vesicle-mediated transport	IBA
GO:0007030	Process	Golgi organization	IMP	26209634
GO:0012505	Component	Endomembrane system	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031175	Process	Neuron projection development	TAS	25492866
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031489	Function	Myosin V binding	IPI	24006491
GO:0036064	Component	Ciliary basal body	IDA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:1903292	Process	Protein localization to Golgi membrane	IBA
GO:1903292	Process	Protein localization to Golgi membrane	IDA	25492866

Other IDs

• MIM: 615852
• HGNC: 14902
• e!Ensembl: ENSG00000154917

Protein

• UniProt ID: Q9NRW1
• Protein name: Ras-related protein Rab-6B (EC 3.6.5.2)
• Protein function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, dr
• PDB: 2E9S , 2FE4 , 2FFQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	15 → 175	Ras family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in brain.
• Sequence:

  MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDR
  TVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQQTSKWIDDVRTERGSDVI
  IMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTGYNVKQLFRRVASALPGMENV
  QEKSKEGMIDIKLDKPQEPPASEGGCSC

• Sequence length: 208

Pathways

Reactome Pathway

COPI-independent Golgi-to-ER retrograde traffic

Retrograde transport at the Trans-Golgi-Network

TBC/RABGAPs

RAB geranylgeranylation

RAB GEFs exchange GTP for GDP on RABs

Related Genes

Sort by: Blended Diseases Pathways Evidence source

RAB6A 5 shared pathwaysRAB GEFs exchange GTP for GDP on RABs, COPI-independent Golgi-to-ER retrograde traffic, TBC/RABGAPs, Retrograde transport at the Trans-Golgi-Network, RAB geranylgeranylation Related via 5 shared pathways including RAB GEFs exchange GTP for GDP on RABs, COPI-independent Golgi-to-ER retrograde traffic. RAB18 3 shared pathwaysRAB GEFs exchange GTP for GDP on RABs, COPI-independent Golgi-to-ER retrograde traffic, RAB geranylgeranylation Related via 3 shared pathways including RAB GEFs exchange GTP for GDP on RABs, COPI-independent Golgi-to-ER retrograde traffic. RAB35 3 shared pathwaysRAB GEFs exchange GTP for GDP on RABs, TBC/RABGAPs, RAB geranylgeranylation Related via 3 shared pathways including RAB GEFs exchange GTP for GDP on RABs, TBC/RABGAPs. RAB8B 3 shared pathwaysRAB GEFs exchange GTP for GDP on RABs, TBC/RABGAPs, RAB geranylgeranylation Related via 3 shared pathways including RAB GEFs exchange GTP for GDP on RABs, TBC/RABGAPs. RAB9B 3 shared pathwaysRAB GEFs exchange GTP for GDP on RABs, Retrograde transport at the Trans-Golgi-Network, RAB geranylgeranylation Related via 3 shared pathways including RAB GEFs exchange GTP for GDP on RABs, Retrograde transport at the Trans-Golgi-Network.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RAB6A	0	[]	5	["RAB GEFs exchange GTP for GDP on RABs","COPI-independent Golgi-to-ER retrograde traffic","TBC\/RABGAPs","Retrograde transport at the Trans-Golgi-Network","RAB geranylgeranylation"]	0	[]
RAB18	0	[]	3	["RAB GEFs exchange GTP for GDP on RABs","COPI-independent Golgi-to-ER retrograde traffic","RAB geranylgeranylation"]	0	[]
RAB35	0	[]	3	["RAB GEFs exchange GTP for GDP on RABs","TBC\/RABGAPs","RAB geranylgeranylation"]	0	[]
RAB8B	0	[]	3	["RAB GEFs exchange GTP for GDP on RABs","TBC\/RABGAPs","RAB geranylgeranylation"]	0	[]
RAB9B	0	[]	3	["RAB GEFs exchange GTP for GDP on RABs","Retrograde transport at the Trans-Golgi-Network","RAB geranylgeranylation"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 1 of 5 related genesRAB6A Insomnia Linked via 1 of 5 related genesRAB6A Obesity Linked via 1 of 5 related genesRAB6A Apert syndrome Linked via 1 of 5 related genesRAB18 Asthma Linked via 1 of 5 related genesRAB18

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	1	["RAB6A"]
Insomnia	1	["RAB6A"]
Obesity	1	["RAB6A"]
Apert syndrome	1	["RAB18"]
Asthma	1	["RAB18"]