Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5711
Gene name	Proteasome 26S subunit, non-ATPase 5
Gene symbol	PSMD5
Synonyms (NCBI Gene)	S5B
Chromosome	9
Chromosome location	9q33.2
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a

368 Show/Hide all (368)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030198	hsa-miR-26b-5p	Microarray	19088304
MIRT726850	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726848	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726849	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1270549	hsa-miR-10a	CLIP-seq
MIRT1270550	hsa-miR-10b	CLIP-seq
MIRT1270551	hsa-miR-1193	CLIP-seq
MIRT1270552	hsa-miR-1253	CLIP-seq
MIRT1270553	hsa-miR-1303	CLIP-seq
MIRT1270554	hsa-miR-141	CLIP-seq
MIRT1270555	hsa-miR-200a	CLIP-seq
MIRT1270556	hsa-miR-25	CLIP-seq
MIRT1270557	hsa-miR-31	CLIP-seq
MIRT1270558	hsa-miR-3119	CLIP-seq
MIRT1270559	hsa-miR-3123	CLIP-seq
MIRT1270560	hsa-miR-3148	CLIP-seq
MIRT1270561	hsa-miR-3152-3p	CLIP-seq
MIRT1270562	hsa-miR-3156-5p	CLIP-seq
MIRT1270563	hsa-miR-32	CLIP-seq
MIRT1270564	hsa-miR-323-5p	CLIP-seq
MIRT1270565	hsa-miR-323b-5p	CLIP-seq
MIRT1270566	hsa-miR-330-3p	CLIP-seq
MIRT1270567	hsa-miR-331-5p	CLIP-seq
MIRT1270568	hsa-miR-3545-3p	CLIP-seq
MIRT1270569	hsa-miR-3613-5p	CLIP-seq
MIRT1270570	hsa-miR-3620	CLIP-seq
MIRT1270571	hsa-miR-363	CLIP-seq
MIRT1270572	hsa-miR-3658	CLIP-seq
MIRT1270573	hsa-miR-3663-5p	CLIP-seq
MIRT1270574	hsa-miR-367	CLIP-seq
MIRT1270575	hsa-miR-3670	CLIP-seq
MIRT1270576	hsa-miR-3688-3p	CLIP-seq
MIRT1270577	hsa-miR-3688-5p	CLIP-seq
MIRT1270578	hsa-miR-3974	CLIP-seq
MIRT1270579	hsa-miR-4303	CLIP-seq
MIRT1270580	hsa-miR-4455	CLIP-seq
MIRT1270581	hsa-miR-4635	CLIP-seq
MIRT1270582	hsa-miR-4662a-5p	CLIP-seq
MIRT1270583	hsa-miR-4668-3p	CLIP-seq
MIRT1270584	hsa-miR-4678	CLIP-seq
MIRT1270585	hsa-miR-4680-5p	CLIP-seq
MIRT1270586	hsa-miR-4682	CLIP-seq
MIRT1270587	hsa-miR-4684-3p	CLIP-seq
MIRT1270588	hsa-miR-4694-3p	CLIP-seq
MIRT1270589	hsa-miR-4694-5p	CLIP-seq
MIRT1270590	hsa-miR-4695-3p	CLIP-seq
MIRT1270591	hsa-miR-4709-3p	CLIP-seq
MIRT1270592	hsa-miR-4755-3p	CLIP-seq
MIRT1270593	hsa-miR-4772-3p	CLIP-seq
MIRT1270594	hsa-miR-4778-5p	CLIP-seq
MIRT1270595	hsa-miR-4803	CLIP-seq
MIRT1270596	hsa-miR-496	CLIP-seq
MIRT1270597	hsa-miR-518a-5p	CLIP-seq
MIRT1270598	hsa-miR-520f	CLIP-seq
MIRT1270599	hsa-miR-527	CLIP-seq
MIRT1270600	hsa-miR-548c-3p	CLIP-seq
MIRT1270601	hsa-miR-548l	CLIP-seq
MIRT1270602	hsa-miR-548n	CLIP-seq
MIRT1270603	hsa-miR-548p	CLIP-seq
MIRT1270604	hsa-miR-552	CLIP-seq
MIRT1270605	hsa-miR-568	CLIP-seq
MIRT1270606	hsa-miR-570	CLIP-seq
MIRT1270607	hsa-miR-587	CLIP-seq
MIRT1270608	hsa-miR-609	CLIP-seq
MIRT1270609	hsa-miR-630	CLIP-seq
MIRT1270610	hsa-miR-767-5p	CLIP-seq
MIRT1270611	hsa-miR-875-3p	CLIP-seq
MIRT1270612	hsa-miR-876-3p	CLIP-seq
MIRT1270613	hsa-miR-889	CLIP-seq
MIRT1270614	hsa-miR-92a	CLIP-seq
MIRT1270615	hsa-miR-92b	CLIP-seq
MIRT2079509	hsa-miR-1237	CLIP-seq
MIRT2079510	hsa-miR-1254	CLIP-seq
MIRT2079511	hsa-miR-138	CLIP-seq
MIRT2079512	hsa-miR-2110	CLIP-seq
MIRT2079513	hsa-miR-3064-5p	CLIP-seq
MIRT2079514	hsa-miR-3116	CLIP-seq
MIRT1270561	hsa-miR-3152-3p	CLIP-seq
MIRT2079515	hsa-miR-3182	CLIP-seq
MIRT1270568	hsa-miR-3545-3p	CLIP-seq
MIRT2079516	hsa-miR-3650	CLIP-seq
MIRT2079517	hsa-miR-3660	CLIP-seq
MIRT2079518	hsa-miR-3909	CLIP-seq
MIRT2079519	hsa-miR-3973	CLIP-seq
MIRT2079520	hsa-miR-4271	CLIP-seq
MIRT1270579	hsa-miR-4303	CLIP-seq
MIRT2079521	hsa-miR-431	CLIP-seq
MIRT2079522	hsa-miR-4310	CLIP-seq
MIRT2079523	hsa-miR-4423-5p	CLIP-seq
MIRT2079524	hsa-miR-448	CLIP-seq
MIRT2079525	hsa-miR-4526	CLIP-seq
MIRT2079526	hsa-miR-4539	CLIP-seq
MIRT2079527	hsa-miR-4652-3p	CLIP-seq
MIRT1270582	hsa-miR-4662a-5p	CLIP-seq
MIRT2079528	hsa-miR-4667-5p	CLIP-seq
MIRT2079529	hsa-miR-4668-5p	CLIP-seq
MIRT1270586	hsa-miR-4682	CLIP-seq
MIRT2079530	hsa-miR-4700-5p	CLIP-seq
MIRT2079531	hsa-miR-4724-5p	CLIP-seq
MIRT2079532	hsa-miR-4725-3p	CLIP-seq
MIRT2079533	hsa-miR-4797-5p	CLIP-seq
MIRT2079534	hsa-miR-495	CLIP-seq
MIRT2079535	hsa-miR-548a-5p	CLIP-seq
MIRT2079536	hsa-miR-548ab	CLIP-seq
MIRT2079537	hsa-miR-548ak	CLIP-seq
MIRT2079538	hsa-miR-548b-5p	CLIP-seq
MIRT2079539	hsa-miR-548c-5p	CLIP-seq
MIRT2079540	hsa-miR-548d-5p	CLIP-seq
MIRT2079541	hsa-miR-548h	CLIP-seq
MIRT2079542	hsa-miR-548i	CLIP-seq
MIRT2079543	hsa-miR-548j	CLIP-seq
MIRT2079544	hsa-miR-548w	CLIP-seq
MIRT2079545	hsa-miR-548y	CLIP-seq
MIRT2079546	hsa-miR-559	CLIP-seq
MIRT2079547	hsa-miR-583	CLIP-seq
MIRT2079548	hsa-miR-586	CLIP-seq
MIRT2079549	hsa-miR-627	CLIP-seq
MIRT2079550	hsa-miR-661	CLIP-seq
MIRT2079551	hsa-miR-802	CLIP-seq
MIRT2079552	hsa-miR-924	CLIP-seq
MIRT2079553	hsa-miR-933	CLIP-seq
MIRT2305821	hsa-miR-1200	CLIP-seq
MIRT2305822	hsa-miR-1202	CLIP-seq
MIRT2079509	hsa-miR-1237	CLIP-seq
MIRT1270552	hsa-miR-1253	CLIP-seq
MIRT2305823	hsa-miR-125a-3p	CLIP-seq
MIRT2305824	hsa-miR-1273g	CLIP-seq
MIRT2305825	hsa-miR-1279	CLIP-seq
MIRT2305826	hsa-miR-1293	CLIP-seq
MIRT1270553	hsa-miR-1303	CLIP-seq
MIRT2305827	hsa-miR-132	CLIP-seq
MIRT2305828	hsa-miR-133a	CLIP-seq
MIRT2305829	hsa-miR-133b	CLIP-seq
MIRT2079511	hsa-miR-138	CLIP-seq
MIRT2305830	hsa-miR-143	CLIP-seq
MIRT2305831	hsa-miR-145	CLIP-seq
MIRT2305832	hsa-miR-1909	CLIP-seq
MIRT2305833	hsa-miR-1915	CLIP-seq
MIRT2305834	hsa-miR-192	CLIP-seq
MIRT2305835	hsa-miR-197	CLIP-seq
MIRT2079512	hsa-miR-2110	CLIP-seq
MIRT2305836	hsa-miR-2113	CLIP-seq
MIRT2305837	hsa-miR-212	CLIP-seq
MIRT2305838	hsa-miR-215	CLIP-seq
MIRT2305839	hsa-miR-2467-3p	CLIP-seq
MIRT1270556	hsa-miR-25	CLIP-seq
MIRT2305840	hsa-miR-299-5p	CLIP-seq
MIRT1270557	hsa-miR-31	CLIP-seq
MIRT1270558	hsa-miR-3119	CLIP-seq
MIRT2305841	hsa-miR-3144-5p	CLIP-seq
MIRT2305842	hsa-miR-3150a-3p	CLIP-seq
MIRT2305843	hsa-miR-3153	CLIP-seq
MIRT2305844	hsa-miR-3155	CLIP-seq
MIRT2305845	hsa-miR-3155b	CLIP-seq
MIRT1270562	hsa-miR-3156-5p	CLIP-seq
MIRT2305846	hsa-miR-3175	CLIP-seq
MIRT2305847	hsa-miR-3187-3p	CLIP-seq
MIRT2305848	hsa-miR-3191	CLIP-seq
MIRT1270563	hsa-miR-32	CLIP-seq
MIRT1270566	hsa-miR-330-3p	CLIP-seq
MIRT1270568	hsa-miR-3545-3p	CLIP-seq
MIRT2305849	hsa-miR-3613-3p	CLIP-seq
MIRT1270571	hsa-miR-363	CLIP-seq
MIRT2305850	hsa-miR-3646	CLIP-seq
MIRT2079516	hsa-miR-3650	CLIP-seq
MIRT2305851	hsa-miR-3651	CLIP-seq
MIRT1270573	hsa-miR-3663-5p	CLIP-seq
MIRT1270574	hsa-miR-367	CLIP-seq
MIRT1270575	hsa-miR-3670	CLIP-seq
MIRT2305852	hsa-miR-3678-3p	CLIP-seq
MIRT1270576	hsa-miR-3688-3p	CLIP-seq
MIRT1270577	hsa-miR-3688-5p	CLIP-seq
MIRT2305853	hsa-miR-3944-5p	CLIP-seq
MIRT2305854	hsa-miR-3972	CLIP-seq
MIRT2305855	hsa-miR-411	CLIP-seq
MIRT2305856	hsa-miR-412	CLIP-seq
MIRT2305857	hsa-miR-4261	CLIP-seq
MIRT737840	hsa-miR-4266	CLIP-seq
MIRT2079520	hsa-miR-4271	CLIP-seq
MIRT2079521	hsa-miR-431	CLIP-seq
MIRT2079522	hsa-miR-4310	CLIP-seq
MIRT2305858	hsa-miR-4324	CLIP-seq
MIRT2079523	hsa-miR-4423-5p	CLIP-seq
MIRT737838	hsa-miR-4434	CLIP-seq
MIRT2305859	hsa-miR-4435	CLIP-seq
MIRT2305860	hsa-miR-4483	CLIP-seq
MIRT2305861	hsa-miR-4505	CLIP-seq
MIRT737839	hsa-miR-4516	CLIP-seq
MIRT2079526	hsa-miR-4539	CLIP-seq
MIRT2305862	hsa-miR-4651	CLIP-seq
MIRT2305863	hsa-miR-4652-5p	CLIP-seq
MIRT2305864	hsa-miR-4659a-5p	CLIP-seq
MIRT2305865	hsa-miR-4659b-5p	CLIP-seq
MIRT2079528	hsa-miR-4667-5p	CLIP-seq
MIRT2079529	hsa-miR-4668-5p	CLIP-seq
MIRT1270590	hsa-miR-4695-3p	CLIP-seq
MIRT2079530	hsa-miR-4700-5p	CLIP-seq
MIRT2305866	hsa-miR-4701-5p	CLIP-seq
MIRT2079531	hsa-miR-4724-5p	CLIP-seq
MIRT2079532	hsa-miR-4725-3p	CLIP-seq
MIRT2305867	hsa-miR-4726-3p	CLIP-seq
MIRT2305868	hsa-miR-4731-5p	CLIP-seq
MIRT2305869	hsa-miR-4753-3p	CLIP-seq
MIRT1270592	hsa-miR-4755-3p	CLIP-seq
MIRT2305870	hsa-miR-4770	CLIP-seq
MIRT2305871	hsa-miR-4775	CLIP-seq
MIRT2305872	hsa-miR-4776-3p	CLIP-seq
MIRT2305873	hsa-miR-4790-3p	CLIP-seq
MIRT2079533	hsa-miR-4797-5p	CLIP-seq
MIRT2305874	hsa-miR-484	CLIP-seq
MIRT2305875	hsa-miR-485-5p	CLIP-seq
MIRT2079534	hsa-miR-495	CLIP-seq
MIRT2305876	hsa-miR-520d-5p	CLIP-seq
MIRT1270598	hsa-miR-520f	CLIP-seq
MIRT2305877	hsa-miR-524-5p	CLIP-seq
MIRT2305878	hsa-miR-544b	CLIP-seq
MIRT2305879	hsa-miR-545	CLIP-seq
MIRT1270600	hsa-miR-548c-3p	CLIP-seq
MIRT1270602	hsa-miR-548n	CLIP-seq
MIRT2305880	hsa-miR-548s	CLIP-seq
MIRT1270604	hsa-miR-552	CLIP-seq
MIRT1270605	hsa-miR-568	CLIP-seq
MIRT2305881	hsa-miR-577	CLIP-seq
MIRT2305882	hsa-miR-588	CLIP-seq
MIRT2305883	hsa-miR-590-3p	CLIP-seq
MIRT2305884	hsa-miR-608	CLIP-seq
MIRT2305885	hsa-miR-633	CLIP-seq
MIRT2305886	hsa-miR-635	CLIP-seq
MIRT2305887	hsa-miR-637	CLIP-seq
MIRT2305888	hsa-miR-758	CLIP-seq
MIRT2305889	hsa-miR-759	CLIP-seq
MIRT1270610	hsa-miR-767-5p	CLIP-seq
MIRT2079551	hsa-miR-802	CLIP-seq
MIRT1270612	hsa-miR-876-3p	CLIP-seq
MIRT2079552	hsa-miR-924	CLIP-seq
MIRT1270614	hsa-miR-92a	CLIP-seq
MIRT1270615	hsa-miR-92b	CLIP-seq
MIRT1270554	hsa-miR-141	CLIP-seq
MIRT1270555	hsa-miR-200a	CLIP-seq
MIRT737840	hsa-miR-4266	CLIP-seq
MIRT1270580	hsa-miR-4455	CLIP-seq
MIRT2079526	hsa-miR-4539	CLIP-seq
MIRT1270608	hsa-miR-609	CLIP-seq
MIRT2305833	hsa-miR-1915	CLIP-seq
MIRT2305835	hsa-miR-197	CLIP-seq
MIRT2305844	hsa-miR-3155	CLIP-seq
MIRT2305845	hsa-miR-3155b	CLIP-seq
MIRT2305856	hsa-miR-412	CLIP-seq
MIRT2079521	hsa-miR-431	CLIP-seq
MIRT2079523	hsa-miR-4423-5p	CLIP-seq
MIRT2305867	hsa-miR-4726-3p	CLIP-seq
MIRT2079533	hsa-miR-4797-5p	CLIP-seq
MIRT2305874	hsa-miR-484	CLIP-seq
MIRT2079552	hsa-miR-924	CLIP-seq
MIRT737837	hsa-miR-105	CLIP-seq
MIRT2079509	hsa-miR-1237	CLIP-seq
MIRT2603094	hsa-miR-1248	CLIP-seq
MIRT2079510	hsa-miR-1254	CLIP-seq
MIRT2603095	hsa-miR-1289	CLIP-seq
MIRT2603096	hsa-miR-1304	CLIP-seq
MIRT2603097	hsa-miR-1323	CLIP-seq
MIRT2305828	hsa-miR-133a	CLIP-seq
MIRT2305829	hsa-miR-133b	CLIP-seq
MIRT2079511	hsa-miR-138	CLIP-seq
MIRT2305833	hsa-miR-1915	CLIP-seq
MIRT2305835	hsa-miR-197	CLIP-seq
MIRT2079512	hsa-miR-2110	CLIP-seq
MIRT2305836	hsa-miR-2113	CLIP-seq
MIRT2305840	hsa-miR-299-5p	CLIP-seq
MIRT2079513	hsa-miR-3064-5p	CLIP-seq
MIRT2603098	hsa-miR-30a	CLIP-seq
MIRT2603099	hsa-miR-30b	CLIP-seq
MIRT2603100	hsa-miR-30c	CLIP-seq
MIRT2603101	hsa-miR-30d	CLIP-seq
MIRT2603102	hsa-miR-30e	CLIP-seq
MIRT2079514	hsa-miR-3116	CLIP-seq
MIRT2603103	hsa-miR-3120-3p	CLIP-seq
MIRT2603104	hsa-miR-3126-5p	CLIP-seq
MIRT2305842	hsa-miR-3150a-3p	CLIP-seq
MIRT2305843	hsa-miR-3153	CLIP-seq
MIRT2305844	hsa-miR-3155	CLIP-seq
MIRT2305845	hsa-miR-3155b	CLIP-seq
MIRT2603105	hsa-miR-3198	CLIP-seq
MIRT2603106	hsa-miR-3611	CLIP-seq
MIRT2305849	hsa-miR-3613-3p	CLIP-seq
MIRT2603107	hsa-miR-361-3p	CLIP-seq
MIRT2079518	hsa-miR-3909	CLIP-seq
MIRT2305856	hsa-miR-412	CLIP-seq
MIRT737840	hsa-miR-4266	CLIP-seq
MIRT2079520	hsa-miR-4271	CLIP-seq
MIRT2603108	hsa-miR-4294	CLIP-seq
MIRT2603109	hsa-miR-4309	CLIP-seq
MIRT2079521	hsa-miR-431	CLIP-seq
MIRT2603110	hsa-miR-4419a	CLIP-seq
MIRT2079523	hsa-miR-4423-5p	CLIP-seq
MIRT737838	hsa-miR-4434	CLIP-seq
MIRT2603111	hsa-miR-4510	CLIP-seq
MIRT737839	hsa-miR-4516	CLIP-seq
MIRT2603112	hsa-miR-4534	CLIP-seq
MIRT2603113	hsa-miR-4645-3p	CLIP-seq
MIRT2079532	hsa-miR-4725-3p	CLIP-seq
MIRT2305867	hsa-miR-4726-3p	CLIP-seq
MIRT2305869	hsa-miR-4753-3p	CLIP-seq
MIRT2603114	hsa-miR-4762-3p	CLIP-seq
MIRT2079533	hsa-miR-4797-5p	CLIP-seq
MIRT2305874	hsa-miR-484	CLIP-seq
MIRT2603115	hsa-miR-500a	CLIP-seq
MIRT737841	hsa-miR-532-5p	CLIP-seq
MIRT2305879	hsa-miR-545	CLIP-seq
MIRT2603116	hsa-miR-548aa	CLIP-seq
MIRT2603117	hsa-miR-548ae	CLIP-seq
MIRT2603118	hsa-miR-548aj	CLIP-seq
MIRT2603119	hsa-miR-548am	CLIP-seq
MIRT2603120	hsa-miR-548o	CLIP-seq
MIRT1270603	hsa-miR-548p	CLIP-seq
MIRT2603121	hsa-miR-548x	CLIP-seq
MIRT2305886	hsa-miR-635	CLIP-seq
MIRT2603122	hsa-miR-651	CLIP-seq
MIRT2079550	hsa-miR-661	CLIP-seq
MIRT2305888	hsa-miR-758	CLIP-seq
MIRT2079552	hsa-miR-924	CLIP-seq
MIRT737837	hsa-miR-105	CLIP-seq
MIRT2079509	hsa-miR-1237	CLIP-seq
MIRT2603094	hsa-miR-1248	CLIP-seq
MIRT2079510	hsa-miR-1254	CLIP-seq
MIRT2603095	hsa-miR-1289	CLIP-seq
MIRT2603096	hsa-miR-1304	CLIP-seq
MIRT2305828	hsa-miR-133a	CLIP-seq
MIRT2305829	hsa-miR-133b	CLIP-seq
MIRT2305833	hsa-miR-1915	CLIP-seq
MIRT2079512	hsa-miR-2110	CLIP-seq
MIRT2305836	hsa-miR-2113	CLIP-seq
MIRT2079513	hsa-miR-3064-5p	CLIP-seq
MIRT2079514	hsa-miR-3116	CLIP-seq
MIRT2603104	hsa-miR-3126-5p	CLIP-seq
MIRT2305842	hsa-miR-3150a-3p	CLIP-seq
MIRT2305843	hsa-miR-3153	CLIP-seq
MIRT2305844	hsa-miR-3155	CLIP-seq
MIRT2305845	hsa-miR-3155b	CLIP-seq
MIRT2603105	hsa-miR-3198	CLIP-seq
MIRT2603106	hsa-miR-3611	CLIP-seq
MIRT2603107	hsa-miR-361-3p	CLIP-seq
MIRT737840	hsa-miR-4266	CLIP-seq
MIRT2079520	hsa-miR-4271	CLIP-seq
MIRT2603108	hsa-miR-4294	CLIP-seq
MIRT2603109	hsa-miR-4309	CLIP-seq
MIRT2603110	hsa-miR-4419a	CLIP-seq
MIRT737838	hsa-miR-4434	CLIP-seq
MIRT2603111	hsa-miR-4510	CLIP-seq
MIRT737839	hsa-miR-4516	CLIP-seq
MIRT2603112	hsa-miR-4534	CLIP-seq
MIRT2603113	hsa-miR-4645-3p	CLIP-seq
MIRT2079532	hsa-miR-4725-3p	CLIP-seq
MIRT2305867	hsa-miR-4726-3p	CLIP-seq
MIRT2305869	hsa-miR-4753-3p	CLIP-seq
MIRT2603114	hsa-miR-4762-3p	CLIP-seq
MIRT2305874	hsa-miR-484	CLIP-seq
MIRT2603115	hsa-miR-500a	CLIP-seq
MIRT737841	hsa-miR-532-5p	CLIP-seq
MIRT2603116	hsa-miR-548aa	CLIP-seq
MIRT2603117	hsa-miR-548ae	CLIP-seq
MIRT2603118	hsa-miR-548aj	CLIP-seq
MIRT2603119	hsa-miR-548am	CLIP-seq
MIRT2603121	hsa-miR-548x	CLIP-seq
MIRT2305886	hsa-miR-635	CLIP-seq
MIRT2603122	hsa-miR-651	CLIP-seq
MIRT2079550	hsa-miR-661	CLIP-seq
MIRT2305888	hsa-miR-758	CLIP-seq

9 Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	TAS	8811196
GO:0005515	Function	Protein binding	IPI	16189514, 19490896, 21516116, 22901813, 25416956, 26496610, 27107012, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008540	Component	Proteasome regulatory particle, base subcomplex	IDA	19412159, 19490896
GO:0022624	Component	Proteasome accessory complex	IEA
GO:0022624	Component	Proteasome accessory complex	ISS
GO:0043248	Process	Proteasome assembly	IEA
GO:0070682	Process	Proteasome regulatory particle assembly	IDA	19490896

MIM	HGNC	e!Ensembl
604452	9563	ENSG00000095261

Q16401

Protein name

26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)

Protein function

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 m

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10508	Proteasom_PSMB	1 → 504	Proteasome non-ATPase 26S subunit	Family

Sequence

MAAQALALLREVARLEAPLEELRALHSVLQAVPLNELRQQAAELRLGPLFSLLNENHREK
TTLCVSILERLLQAMEPVHVARNLRVDLQRGLIHPDDSVKILTLSQIGRIVENSDAVTEI
LNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDI
VRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHG
RQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAVMDSPQQICERYPIFVEKV
FEMIESQDPTMIGVAVDTVGILGSNVEGKQVLQKTGTRFERLLMRIGHQSKNAPVELKIR
CLDAISSLLYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISSQPFPELHCAALKVFTA
IANQPWAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLR
LRTYLSEGPYYVKPVSTTAVEGAE

Sequence length

504

Interactions

View interactions

Reactome Pathway
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE DISEASE	—	GWAS catalog	30595370	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (8)
Arthritis Juvenile	Juvenile arthritis	Pubtator	35967305	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	33740106	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1	Autoimmune Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	Autoimmune Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Neoplasms	Intestinal Neoplasms	BEFREE	29716915		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	33740106	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	37349676	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PSMD10	0	[]	50	["Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21","Orc1 removal from chromatin","CDK-mediated phosphorylation and removal of Cdc6","Ubiquitin-dependent degradation of Cyclin D","Activation of NF-kappaB in B cells","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"]	0	[]
PSMB9	1	["Autoimmune disease"]	50	["Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21","Orc1 removal from chromatin","CDK-mediated phosphorylation and removal of Cdc6","Ubiquitin-dependent degradation of Cyclin D","Activation of NF-kappaB in B cells","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"]	1	["GWAS catalog (Autoimmune disease)"]
PSMB10	0	[]	50	["Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21","Orc1 removal from chromatin","CDK-mediated phosphorylation and removal of Cdc6","Ubiquitin-dependent degradation of Cyclin D","Activation of NF-kappaB in B cells","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"]	0	[]
PSMF1	0	[]	50	["Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21","Orc1 removal from chromatin","CDK-mediated phosphorylation and removal of Cdc6","Ubiquitin-dependent degradation of Cyclin D","Activation of NF-kappaB in B cells","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"]	0	[]
PSMB8	0	[]	50	["Regulation of PTEN stability and activity","Ub-specific processing proteases","Neddylation","Separation of Sister Chromatids","ABC-family proteins mediated transport","Regulation of RAS by GAPs","SCF(Skp2)-mediated degradation of p27\/p21","Orc1 removal from chromatin","CDK-mediated phosphorylation and removal of Cdc6","Ubiquitin-dependent degradation of Cyclin D","Activation of NF-kappaB in B cells","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"]	0	[]

PSMD5 (proteasome 26S subunit, non-ATPase 5)

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