Gene Gene information from NCBI Gene database.
Entrez ID 5711
Gene name Proteasome 26S subunit, non-ATPase 5
Gene symbol PSMD5
Synonyms (NCBI Gene)
S5B
Chromosome 9
Chromosome location 9q33.2
Summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a
miRNA miRNA information provided by mirtarbase database.
368
miRTarBase ID miRNA Experiments Reference
MIRT030198 hsa-miR-26b-5p Microarray 19088304
MIRT726850 hsa-miR-92a-3p HITS-CLIP 22473208
MIRT726848 hsa-miR-92b-3p HITS-CLIP 22473208
MIRT726849 hsa-miR-32-5p HITS-CLIP 22473208
MIRT1270549 hsa-miR-10a CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0000502 Component Proteasome complex TAS 8811196
GO:0005515 Function Protein binding IPI 16189514, 19490896, 21516116, 22901813, 25416956, 26496610, 27107012, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005829 Component Cytosol IEA
GO:0005829 Component Cytosol TAS
GO:0008540 Component Proteasome regulatory particle, base subcomplex IDA 19412159, 19490896
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604452 9563 ENSG00000095261
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16401
Protein name 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)
Protein function Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 m
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10508 Proteasom_PSMB 1 504 Proteasome non-ATPase 26S subunit Family
Sequence
Sequence length 504
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTOIMMUNE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arthritis Juvenile Juvenile arthritis Pubtator 35967305 Associate
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 33740106 Associate
★☆☆☆☆
Found in Text Mining only
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 Autoimmune Diseases GWASCAT_DG 30595370
★☆☆☆☆
Found in Text Mining only
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 Autoimmune Diseases GWASCAT_DG 30595370
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases GWASCAT_DG 30595370
★☆☆☆☆
Found in Text Mining only
Intestinal Neoplasms Intestinal Neoplasms BEFREE 29716915
★☆☆☆☆
Found in Text Mining only
Osteoporosis Osteoporosis Pubtator 33740106 Associate
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Ovarian neoplasm Pubtator 37349676 Associate
★☆☆☆☆
Found in Text Mining only