PRPF38B (pre-mRNA processing factor 38B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55119
• Gene name: Pre-mRNA processing factor 38B
• Gene symbol: PRPF38B
• Synonyms (NCBI Gene): NET1
• Chromosome: 1
• Chromosome location: 1p13.3

miRNA Show/Hide all (163)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027254	hsa-miR-101-3p	Sequencing	20371350
MIRT038040	hsa-miR-423-5p	CLASH	23622248
MIRT036833	hsa-miR-877-3p	CLASH	23622248
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT528633	hsa-miR-6073	PAR-CLIP	20371350
MIRT528632	hsa-miR-142-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	22012620
MIRT528633	hsa-miR-6073	PAR-CLIP	22012620
MIRT528632	hsa-miR-142-3p	PAR-CLIP	22012620
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT483517	hsa-miR-136-3p	PAR-CLIP	27292025
MIRT528632	hsa-miR-142-3p	PAR-CLIP	27292025
MIRT528633	hsa-miR-6073	PAR-CLIP	27292025
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT528633	hsa-miR-6073	PAR-CLIP	20371350
MIRT528632	hsa-miR-142-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	20371350
MIRT483517	hsa-miR-136-3p	PAR-CLIP	22012620
MIRT528633	hsa-miR-6073	PAR-CLIP	22012620
MIRT528632	hsa-miR-142-3p	PAR-CLIP	22012620
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT483517	hsa-miR-136-3p	PAR-CLIP	23592263
MIRT1265432	hsa-miR-101	CLIP-seq
MIRT1265433	hsa-miR-103a	CLIP-seq
MIRT1265434	hsa-miR-107	CLIP-seq
MIRT1265435	hsa-miR-1179	CLIP-seq
MIRT1265436	hsa-miR-1224-5p	CLIP-seq
MIRT1265437	hsa-miR-1228	CLIP-seq
MIRT1265438	hsa-miR-1248	CLIP-seq
MIRT1265439	hsa-miR-1275	CLIP-seq
MIRT1265440	hsa-miR-1283	CLIP-seq
MIRT1265441	hsa-miR-137	CLIP-seq
MIRT1265442	hsa-miR-144	CLIP-seq
MIRT1265443	hsa-miR-188-3p	CLIP-seq
MIRT1265444	hsa-miR-194	CLIP-seq
MIRT1265445	hsa-miR-200b	CLIP-seq
MIRT1265446	hsa-miR-200c	CLIP-seq
MIRT1265447	hsa-miR-2053	CLIP-seq
MIRT1265448	hsa-miR-216a	CLIP-seq
MIRT1265449	hsa-miR-217	CLIP-seq
MIRT1265450	hsa-miR-2276	CLIP-seq
MIRT1265451	hsa-miR-296-3p	CLIP-seq
MIRT1265452	hsa-miR-300	CLIP-seq
MIRT1265453	hsa-miR-3121-3p	CLIP-seq
MIRT1265454	hsa-miR-3146	CLIP-seq
MIRT1265455	hsa-miR-3148	CLIP-seq
MIRT1265456	hsa-miR-3150b-3p	CLIP-seq
MIRT1265457	hsa-miR-3189-5p	CLIP-seq
MIRT1265458	hsa-miR-34a	CLIP-seq
MIRT1265459	hsa-miR-34c-5p	CLIP-seq
MIRT1265460	hsa-miR-3613-3p	CLIP-seq
MIRT1265461	hsa-miR-3667-5p	CLIP-seq
MIRT1265462	hsa-miR-3677-5p	CLIP-seq
MIRT1265463	hsa-miR-374c	CLIP-seq
MIRT1265464	hsa-miR-381	CLIP-seq
MIRT1265465	hsa-miR-3915	CLIP-seq
MIRT1265466	hsa-miR-3973	CLIP-seq
MIRT1265467	hsa-miR-411	CLIP-seq
MIRT1265468	hsa-miR-4270	CLIP-seq
MIRT1265469	hsa-miR-4282	CLIP-seq
MIRT1265470	hsa-miR-429	CLIP-seq
MIRT1265471	hsa-miR-4297	CLIP-seq
MIRT1265472	hsa-miR-4310	CLIP-seq
MIRT1265473	hsa-miR-4418	CLIP-seq
MIRT1265474	hsa-miR-4436a	CLIP-seq
MIRT1265475	hsa-miR-4441	CLIP-seq
MIRT1265476	hsa-miR-4447	CLIP-seq
MIRT1265477	hsa-miR-4460	CLIP-seq
MIRT1265478	hsa-miR-4471	CLIP-seq
MIRT1265479	hsa-miR-4472	CLIP-seq
MIRT1265480	hsa-miR-4494	CLIP-seq
MIRT1265481	hsa-miR-449a	CLIP-seq
MIRT1265482	hsa-miR-449b	CLIP-seq
MIRT1265483	hsa-miR-4525	CLIP-seq
MIRT1265484	hsa-miR-4665-5p	CLIP-seq
MIRT1265485	hsa-miR-4666-3p	CLIP-seq
MIRT1265486	hsa-miR-4666-5p	CLIP-seq
MIRT1265487	hsa-miR-4668-5p	CLIP-seq
MIRT1265488	hsa-miR-4689	CLIP-seq
MIRT1265489	hsa-miR-4696	CLIP-seq
MIRT1265490	hsa-miR-4723-5p	CLIP-seq
MIRT1265491	hsa-miR-4727-3p	CLIP-seq
MIRT1265492	hsa-miR-4731-3p	CLIP-seq
MIRT1265493	hsa-miR-4758-3p	CLIP-seq
MIRT1265494	hsa-miR-4772-3p	CLIP-seq
MIRT1265495	hsa-miR-4777-5p	CLIP-seq
MIRT1265496	hsa-miR-4784	CLIP-seq
MIRT1265497	hsa-miR-4789-5p	CLIP-seq
MIRT1265498	hsa-miR-4801	CLIP-seq
MIRT1265499	hsa-miR-4802-3p	CLIP-seq
MIRT1265500	hsa-miR-489	CLIP-seq
MIRT1265501	hsa-miR-495	CLIP-seq
MIRT1265502	hsa-miR-500a	CLIP-seq
MIRT1265503	hsa-miR-509-3-5p	CLIP-seq
MIRT1265504	hsa-miR-509-5p	CLIP-seq
MIRT1265505	hsa-miR-514	CLIP-seq
MIRT1265506	hsa-miR-514b-3p	CLIP-seq
MIRT1265507	hsa-miR-518d-5p	CLIP-seq
MIRT1265508	hsa-miR-519b-5p	CLIP-seq
MIRT1265509	hsa-miR-519c-5p	CLIP-seq
MIRT1265510	hsa-miR-520c-5p	CLIP-seq
MIRT1265511	hsa-miR-526a	CLIP-seq
MIRT1265512	hsa-miR-544	CLIP-seq
MIRT1265513	hsa-miR-548a-5p	CLIP-seq
MIRT1265514	hsa-miR-548ab	CLIP-seq
MIRT1265515	hsa-miR-548ak	CLIP-seq
MIRT1265516	hsa-miR-548b-5p	CLIP-seq
MIRT1265517	hsa-miR-548c-5p	CLIP-seq
MIRT1265518	hsa-miR-548d-5p	CLIP-seq
MIRT1265519	hsa-miR-548h	CLIP-seq
MIRT1265520	hsa-miR-548i	CLIP-seq
MIRT1265521	hsa-miR-548j	CLIP-seq
MIRT1265522	hsa-miR-548w	CLIP-seq
MIRT1265523	hsa-miR-548y	CLIP-seq
MIRT1265524	hsa-miR-559	CLIP-seq
MIRT1265525	hsa-miR-569	CLIP-seq
MIRT1265526	hsa-miR-578	CLIP-seq
MIRT1265527	hsa-miR-606	CLIP-seq
MIRT1265528	hsa-miR-607	CLIP-seq
MIRT1265529	hsa-miR-625	CLIP-seq
MIRT1265530	hsa-miR-643	CLIP-seq
MIRT1265531	hsa-miR-655	CLIP-seq
MIRT1265532	hsa-miR-885-3p	CLIP-seq
MIRT1265533	hsa-miR-885-5p	CLIP-seq
MIRT1265534	hsa-miR-936	CLIP-seq
MIRT2078039	hsa-miR-186	CLIP-seq
MIRT1265452	hsa-miR-300	CLIP-seq
MIRT1265464	hsa-miR-381	CLIP-seq
MIRT1265433	hsa-miR-103a	CLIP-seq
MIRT1265434	hsa-miR-107	CLIP-seq
MIRT1265436	hsa-miR-1224-5p	CLIP-seq
MIRT1265449	hsa-miR-217	CLIP-seq
MIRT2304540	hsa-miR-3125	CLIP-seq
MIRT1265456	hsa-miR-3150b-3p	CLIP-seq
MIRT2304541	hsa-miR-3162-3p	CLIP-seq
MIRT2304542	hsa-miR-3646	CLIP-seq
MIRT2304543	hsa-miR-3647-3p	CLIP-seq
MIRT1265465	hsa-miR-3915	CLIP-seq
MIRT2304544	hsa-miR-3916	CLIP-seq
MIRT1265468	hsa-miR-4270	CLIP-seq
MIRT1265473	hsa-miR-4418	CLIP-seq
MIRT1265474	hsa-miR-4436a	CLIP-seq
MIRT1265475	hsa-miR-4441	CLIP-seq
MIRT1265488	hsa-miR-4689	CLIP-seq
MIRT1265496	hsa-miR-4784	CLIP-seq
MIRT1265503	hsa-miR-509-3-5p	CLIP-seq
MIRT1265504	hsa-miR-509-5p	CLIP-seq
MIRT2304545	hsa-miR-583	CLIP-seq
MIRT1265527	hsa-miR-606	CLIP-seq
MIRT2601535	hsa-miR-1297	CLIP-seq
MIRT2601536	hsa-miR-26a	CLIP-seq
MIRT2601537	hsa-miR-26b	CLIP-seq
MIRT2601538	hsa-miR-2861	CLIP-seq
MIRT2601539	hsa-miR-3913-3p	CLIP-seq
MIRT2601540	hsa-miR-4465	CLIP-seq
MIRT1265478	hsa-miR-4471	CLIP-seq
MIRT2601541	hsa-miR-4757-5p	CLIP-seq
MIRT2601542	hsa-miR-4769-3p	CLIP-seq
MIRT1265500	hsa-miR-489	CLIP-seq
MIRT2601543	hsa-miR-576-5p	CLIP-seq
MIRT2601544	hsa-miR-630	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005634	Component	Nucleus	IEA
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0071011	Component	Precatalytic spliceosome	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5VTL8
• Protein name: Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27)
• Protein function: May be required for pre-mRNA splicing.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03371	PRP38	47 → 231	PRP38 family	Family

• Sequence:

  MANNSPALTGNSQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNP
  MILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEKGSRKTAGQTGMCGGVRGVG
  TGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFES
  FLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTLFPRIPVPVQKNIDQQIKTRPRKI
  KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE
  RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN
  ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK
  KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTD
  SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHK
  NKDETV

• Sequence length: 546

Pathways

KEGG Pathway:

Spliceosome

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NASOPHARYNGEAL NEOPLASM	—	GWAS catalog	24376627	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (40)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	31046876		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	LHGDN	16552434		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	21857017, 24375299, 24596379		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	31046876		★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	20039948	Associate	★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	BEFREE	15717291, 17994190, 20039948, 23872233		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	BEFREE	23945136		★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	Pubtator	23945136	Stimulate	★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29620229		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	21979892		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19124484, 20406972, 21857017, 21986943, 24596379, 29348822, 29769144		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19124484, 23380069, 23689132, 24897521, 30332929	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12115476		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	20590388, 24885292, 27216880, 31128017, 32641699, 36458010	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29620229		★☆☆☆☆ Found in Text Mining only
Cervical Intraepithelial Neoplasia	Cervical Intraepithelial Neoplasia	BEFREE	12115476		★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	31046876		★☆☆☆☆ Found in Text Mining only
Dentinogenesis Imperfecta	Dentinogenesis Imperfecta	BEFREE	19029076		★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	16552434, 18827818, 23945136, 24375299		★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	29348822		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	18214716, 22378020, 23636606, 25113254, 27216880, 30301500, 30867719, 31544556		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	18214716		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32420320, 33955315	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19124484, 20406972, 21857017, 21986943, 24596379, 29348822, 29769144		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	23945136		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gastrointestinal tract	Malignant gastrointestinal tract tumors	BEFREE	24375299		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	16552434, 18827818, 21284875, 31451992		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29620229		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23184663, 24375299, 26080853, 28511963, 29695506, 29769144, 31046876, 31088838		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	19124484		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16552434, 18827818, 21979892, 24375299, 28511963, 29769144, 30301500, 31544556, 31657628		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26459749		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34001978	Associate	★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	31046876		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	24196235, 26080853		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	16552434, 18827818, 21284875, 31451992		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	16552434, 21284875, 23945136	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	18827818	Stimulate	★☆☆☆☆ Found in Text Mining only
Subarachnoid Hemorrhage	Subarachnoid hemorrhage	BEFREE	30531151		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MMP2 2 shared diseasesMyopia, Nasopharyngeal neoplasms 1 shared evidence sourceDisgenet (Myopia) Related via 2 shared diseases including Myopia, Nasopharyngeal neoplasms — evidence mostly Disgenet. HLA-DQB1 2 shared diseasesMyopia, Nasopharyngeal neoplasms 2 shared evidence sourcesDisgenet (Myopia), GWAS catalog (Nasopharyngeal neoplasms) Related via 2 shared diseases including Myopia, Nasopharyngeal neoplasms — evidence mostly Disgenet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MMP2	2	["Myopia","Nasopharyngeal neoplasms"]	0	[]	1	["Disgenet (Myopia)"]
HLA-DQB1	2	["Myopia","Nasopharyngeal neoplasms"]	0	[]	2	["Disgenet (Myopia)","GWAS catalog (Nasopharyngeal neoplasms)"]

Diseases Linked via Similar Genes

Rheumatoid arthritis Linked via 2 of 2 related genesMMP2, HLA-DQB1 Hepatocellular carcinoma Linked via 2 of 2 related genesMMP2, HLA-DQB1 Colorectal cancer Linked via 2 of 2 related genesMMP2, HLA-DQB1 Diabetic neuropathy Linked via 2 of 2 related genesMMP2, HLA-DQB1 Diabetic retinopathy Linked via 2 of 2 related genesMMP2, HLA-DQB1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Rheumatoid arthritis	2	["MMP2","HLA-DQB1"]
Hepatocellular carcinoma	2	["MMP2","HLA-DQB1"]
Colorectal cancer	2	["MMP2","HLA-DQB1"]
Diabetic neuropathy	2	["MMP2","HLA-DQB1"]
Diabetic retinopathy	2	["MMP2","HLA-DQB1"]