POLD2 (DNA polymerase delta 2, accessory subunit)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5425
• Gene name: DNA polymerase delta 2, accessory subunit
• Gene symbol: POLD2
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7p13
• Summary: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3` to 5` exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimu

miRNA Show/Hide all (60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001608	hsa-let-7b-5p	pSILAC	18668040
MIRT001608	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT046820	hsa-miR-222-3p	CLASH	23622248
MIRT1247193	hsa-miR-1205	CLIP-seq
MIRT1247194	hsa-miR-1285	CLIP-seq
MIRT1247195	hsa-miR-1909	CLIP-seq
MIRT1247196	hsa-miR-2861	CLIP-seq
MIRT1247197	hsa-miR-3183	CLIP-seq
MIRT1247198	hsa-miR-3187-5p	CLIP-seq
MIRT1247199	hsa-miR-326	CLIP-seq
MIRT1247200	hsa-miR-330-5p	CLIP-seq
MIRT1247201	hsa-miR-378g	CLIP-seq
MIRT1247202	hsa-miR-4418	CLIP-seq
MIRT1247203	hsa-miR-4486	CLIP-seq
MIRT1247204	hsa-miR-4699-3p	CLIP-seq
MIRT1247205	hsa-miR-4723-3p	CLIP-seq
MIRT1247206	hsa-miR-4757-5p	CLIP-seq
MIRT1247207	hsa-miR-509-3-5p	CLIP-seq
MIRT1247208	hsa-miR-509-5p	CLIP-seq
MIRT1247209	hsa-miR-612	CLIP-seq
MIRT1247193	hsa-miR-1205	CLIP-seq
MIRT1247194	hsa-miR-1285	CLIP-seq
MIRT2072893	hsa-miR-1323	CLIP-seq
MIRT1247195	hsa-miR-1909	CLIP-seq
MIRT1247196	hsa-miR-2861	CLIP-seq
MIRT1247197	hsa-miR-3183	CLIP-seq
MIRT1247198	hsa-miR-3187-5p	CLIP-seq
MIRT1247199	hsa-miR-326	CLIP-seq
MIRT1247200	hsa-miR-330-5p	CLIP-seq
MIRT2072894	hsa-miR-3663-5p	CLIP-seq
MIRT1247201	hsa-miR-378g	CLIP-seq
MIRT1247202	hsa-miR-4418	CLIP-seq
MIRT1247203	hsa-miR-4486	CLIP-seq
MIRT1247205	hsa-miR-4723-3p	CLIP-seq
MIRT1247206	hsa-miR-4757-5p	CLIP-seq
MIRT1247207	hsa-miR-509-3-5p	CLIP-seq
MIRT1247208	hsa-miR-509-5p	CLIP-seq
MIRT2072895	hsa-miR-548aa	CLIP-seq
MIRT2072896	hsa-miR-548o	CLIP-seq
MIRT1247209	hsa-miR-612	CLIP-seq
MIRT1247193	hsa-miR-1205	CLIP-seq
MIRT1247194	hsa-miR-1285	CLIP-seq
MIRT2072893	hsa-miR-1323	CLIP-seq
MIRT1247195	hsa-miR-1909	CLIP-seq
MIRT1247196	hsa-miR-2861	CLIP-seq
MIRT1247197	hsa-miR-3183	CLIP-seq
MIRT1247198	hsa-miR-3187-5p	CLIP-seq
MIRT1247199	hsa-miR-326	CLIP-seq
MIRT1247200	hsa-miR-330-5p	CLIP-seq
MIRT2072894	hsa-miR-3663-5p	CLIP-seq
MIRT1247201	hsa-miR-378g	CLIP-seq
MIRT1247202	hsa-miR-4418	CLIP-seq
MIRT1247203	hsa-miR-4486	CLIP-seq
MIRT1247205	hsa-miR-4723-3p	CLIP-seq
MIRT1247206	hsa-miR-4757-5p	CLIP-seq
MIRT1247207	hsa-miR-509-3-5p	CLIP-seq
MIRT1247208	hsa-miR-509-5p	CLIP-seq
MIRT2072895	hsa-miR-548aa	CLIP-seq
MIRT2072896	hsa-miR-548o	CLIP-seq
MIRT1247209	hsa-miR-612	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREB1	Unknown	10978529
JUN	Unknown	10978529
NFIC	Unknown	10978529
SP1	Unknown	10978529
TFAP2A	Unknown	10978529

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12403614, 15670210, 16000169, 16510448, 26030842, 26496610, 28514442, 31449058, 33961781, 38554706
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8530069
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006260	Process	DNA replication	IEA
GO:0006260	Process	DNA replication	TAS	8530069
GO:0006261	Process	DNA-templated DNA replication	IDA	20334433
GO:0006271	Process	DNA strand elongation involved in DNA replication	IBA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0016035	Component	Zeta DNA polymerase complex	IDA	22465957
GO:0016035	Component	Zeta DNA polymerase complex	IPI	24449906
GO:0042276	Process	Error-prone translesion synthesis	IDA	24449906
GO:0043625	Component	Delta DNA polymerase complex	IBA
GO:0043625	Component	Delta DNA polymerase complex	IDA	11595739, 22465957
GO:0043625	Component	Delta DNA polymerase complex	IEA
GO:0043625	Component	Delta DNA polymerase complex	IPI	12403614
GO:0071897	Process	DNA biosynthetic process	IDA	11595739
GO:0071897	Process	DNA biosynthetic process	IEA

Other IDs

• MIM: 600815
• HGNC: 9176
• e!Ensembl: ENSG00000106628

Protein

• UniProt ID: P49005
• Protein name: DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50)
• Protein function: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Po
• PDB: 3E0J , 6S1M , 6S1N , 6S1O , 6TNY , 6TNZ , 9EKB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04042	DNA_pol_E_B	196 → 412	DNA polymerase alpha/epsilon subunit B	Family
  PF18018	DNA_pol_D_N	49 → 176	DNA polymerase delta subunit OB-fold domain	Domain

• Sequence:

  MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQ
  MRPFLENRAQQHWGSGVGVKKLCELQPEEKCCVVGTLFKAMPLQPSILREVSEEHNLLPQ
  PPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVFGSVRDDGKFLVEDYCFAD
  LAPQKPAPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSR
  VILAGNLLSHSTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFD
  PTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMED
  HLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFGSKIIRGPED
  QTVLLVTVPDFSATQTACLVNLRSLACQPISFSGFGAEDDDLGGLGLGP

• Sequence length: 469

Pathways

KEGG Pathway	Reactome Pathway
DNA replication	Recognition of DNA damage by PCNA-containing replication complex
Base excision repair	Polymerase switching on the C-strand of the telomere
Nucleotide excision repair	Processive synthesis on the C-strand of the telomere
Mismatch repair	Telomere C-strand (Lagging Strand) Synthesis
Homologous recombination	Removal of the Flap Intermediate from the C-strand
	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
	PCNA-Dependent Long Patch Base Excision Repair
	Termination of translesion DNA synthesis
	HDR through Homologous Recombination (HRR)
	Gap-filling DNA repair synthesis and ligation in GG-NER
	Dual Incision in GG-NER
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	Polymerase switching
	Removal of the Flap Intermediate
	Processive synthesis on the lagging strand

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (16)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
non-severe combined immunodeficiency due to polymerase delta deficiency	—	ClinGen	ClinGen report	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (13)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anaplasia	Anaplasia	BEFREE	21079801		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35224098	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	21079801		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms Hereditary Nonpolyposis	Lynch syndrome	Pubtator	31297992	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	26635288	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	19602686	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	21079801		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	36861411	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	34116171	Associate	★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	28367114		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	27806724	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	26635288		★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	30038717		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

POLD1 1 shared diseasenon-severe combined immunodeficiency due to polymerase delta deficiency 22 shared pathwaysDNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair, Homologous recombination, Dual Incision in GG-NER, Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, HDR through Homologous Recombination (HRR), Recognition of DNA damage by PCNA-containing replication complex, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere +10 more 1 shared evidence sourceClinGen (non-severe combined immunodeficiency due to polymerase delta deficiency) Related via 22 shared pathways including DNA replication, Base excision repair — evidence mostly ClinGen. POLD3 22 shared pathwaysDNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair, Homologous recombination, Dual Incision in GG-NER, Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, HDR through Homologous Recombination (HRR), Recognition of DNA damage by PCNA-containing replication complex, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere +10 more Related via 22 shared pathways including DNA replication, Base excision repair. POLD4 22 shared pathwaysDNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair, Homologous recombination, Dual Incision in GG-NER, Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, HDR through Homologous Recombination (HRR), Recognition of DNA damage by PCNA-containing replication complex, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere +10 more Related via 22 shared pathways including DNA replication, Base excision repair. PCNA 20 shared pathwaysDNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair, Dual Incision in GG-NER, Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, HDR through Homologous Recombination (HRR), Recognition of DNA damage by PCNA-containing replication complex, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis +8 more Related via 20 shared pathways including DNA replication, Base excision repair. RFC1 14 shared pathwaysDNA replication, Base excision repair, Nucleotide excision repair, Mismatch repair, Dual Incision in GG-NER, Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, HDR through Homologous Recombination (HRR), Recognition of DNA damage by PCNA-containing replication complex, Polymerase switching on the C-strand of the telomere, PCNA-Dependent Long Patch Base Excision Repair, Termination of translesion DNA synthesis +2 more Related via 14 shared pathways including DNA replication, Base excision repair.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
POLD1	1	["non-severe combined immunodeficiency due to polymerase delta deficiency"]	22	["DNA replication","Base excision repair","Nucleotide excision repair","Mismatch repair","Homologous recombination","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Homologous Recombination (HRR)","Recognition of DNA damage by PCNA-containing replication complex","Polymerase switching on the C-strand of the telomere","Processive synthesis on the C-strand of the telomere"]	1	["ClinGen (non-severe combined immunodeficiency due to polymerase delta deficiency)"]
POLD3	0	[]	22	["DNA replication","Base excision repair","Nucleotide excision repair","Mismatch repair","Homologous recombination","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Homologous Recombination (HRR)","Recognition of DNA damage by PCNA-containing replication complex","Polymerase switching on the C-strand of the telomere","Processive synthesis on the C-strand of the telomere"]	0	[]
POLD4	0	[]	22	["DNA replication","Base excision repair","Nucleotide excision repair","Mismatch repair","Homologous recombination","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Homologous Recombination (HRR)","Recognition of DNA damage by PCNA-containing replication complex","Polymerase switching on the C-strand of the telomere","Processive synthesis on the C-strand of the telomere"]	0	[]
PCNA	0	[]	20	["DNA replication","Base excision repair","Nucleotide excision repair","Mismatch repair","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Homologous Recombination (HRR)","Recognition of DNA damage by PCNA-containing replication complex","Polymerase switching on the C-strand of the telomere","Processive synthesis on the C-strand of the telomere","Telomere C-strand (Lagging Strand) Synthesis"]	0	[]
RFC1	0	[]	14	["DNA replication","Base excision repair","Nucleotide excision repair","Mismatch repair","Dual Incision in GG-NER","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","HDR through Homologous Recombination (HRR)","Recognition of DNA damage by PCNA-containing replication complex","Polymerase switching on the C-strand of the telomere","PCNA-Dependent Long Patch Base Excision Repair","Termination of translesion DNA synthesis"]	0	[]

Diseases Linked via Similar Genes

Atrial fibrillation Linked via 2 of 5 related genesPOLD1, POLD3 Colorectal neoplasms Linked via 2 of 5 related genesPOLD1, POLD3 Colorectal cancer Linked via 2 of 5 related genesPOLD1, POLD3 Immunodeficiency Linked via 2 of 5 related genesPOLD1, POLD3 Colonic neoplasms Linked via 2 of 5 related genesPCNA, RFC1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Atrial fibrillation	2	["POLD1","POLD3"]
Colorectal neoplasms	2	["POLD1","POLD3"]
Colorectal cancer	2	["POLD1","POLD3"]
Immunodeficiency	2	["POLD1","POLD3"]
Colonic neoplasms	2	["PCNA","RFC1"]