PLPP5 (phospholipid phosphatase 5)

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Gene Gene information from NCBI Gene database.
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Entrez ID 84513
Gene name Phospholipid phosphatase 5
Gene symbol PLPP5
Synonyms (NCBI Gene)
DPPL1HTPAPPPAPDC1B
Chromosome 8
Chromosome location 8p11.23
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
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GO ID Ontology Definition Evidence Reference
GO:0000810 Function Diacylglycerol diphosphate phosphatase activity IDA 17590538
GO:0000810 Function Diacylglycerol diphosphate phosphatase activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm TAS 21219541
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
610626 25026 ENSG00000147535
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NEB5
Protein name Phospholipid phosphatase 5 (EC 3.1.3.4) (EC 3.6.1.75) (Phosphatidic acid phosphatase type 2 domain-containing protein 1B)
Protein function Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01569 PAP2 89 → 234 PAP2 superfamily Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:17590538}.
Sequence 
MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPM
FVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFY
RCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRG
KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAEC
HKPFQDKLVLSTAQKPGDSYCFDI
Sequence length 264
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Glycerolipid metabolism Role of phospholipids in phagocytosis
Glycerophospholipid metabolism  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Ovarian serous cystadenocarcinoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (14)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 24051013
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 18757432, 24051013
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 21219541, 24603412 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 24051013
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma LHGDN 16261160
★★★★★
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 16261160, 21219541, 21531764, 24603412
★★★★★
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung Neoplasms BEFREE 24051013
★★★★★
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression BEFREE 28596527
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 18757432, 24051013
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 24051013
★★★★★
★☆☆☆☆
Found in Text Mining only
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PLPP4 3 shared pathwaysGlycerolipid metabolism, Glycerophospholipid metabolism, Role of phospholipids in phagocytosis Related via 3 shared pathways including Glycerolipid metabolism, Glycerophospholipid metabolism. GPAT4 2 shared pathwaysGlycerolipid metabolism, Glycerophospholipid metabolism Related via 2 shared pathways including Glycerolipid metabolism, Glycerophospholipid metabolism. GPAT3 2 shared pathwaysGlycerolipid metabolism, Glycerophospholipid metabolism Related via 2 shared pathways including Glycerolipid metabolism, Glycerophospholipid metabolism. PLD3 2 shared pathwaysGlycerophospholipid metabolism, Role of phospholipids in phagocytosis Related via 2 shared pathways including Glycerophospholipid metabolism, Role of phospholipids in phagocytosis. MBOAT2 2 shared pathwaysGlycerolipid metabolism, Glycerophospholipid metabolism Related via 2 shared pathways including Glycerolipid metabolism, Glycerophospholipid metabolism.
Alzheimer disease Linked via 3 of 5 related genesPLPP4, GPAT3, PLD3 Bipolar disorder Linked via 1 of 5 related genesPLPP4 Color vision deficiency Linked via 1 of 5 related genesPLPP4 Major depressive disorder Linked via 1 of 5 related genesPLPP4 Parkinson disease Linked via 1 of 5 related genesPLPP4