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Gene Gene information from NCBI Gene database.
Entrez ID 8503
Gene name Phosphoinositide-3-kinase regulatory subunit 3
Gene symbol PIK3R3
Synonyms (NCBI Gene)
p55p55-GAMMAp55PIK
Chromosome 1
Chromosome location 1p34.1
Summary Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene
miRNA miRNA information provided by mirtarbase database.
757 Show/Hide all (757)
miRTarBase ID miRNA Experiments Reference
MIRT043293 hsa-miR-331-3p CLASH 23622248
MIRT042712 hsa-miR-346 CLASH 23622248
MIRT040803 hsa-miR-18a-3p CLASH 23622248
MIRT053541 hsa-miR-7-5p ELISALuciferase reporter assayqRT-PCRWestern blot 23135998
MIRT726939 hsa-miR-19a-3p HITS-CLIP 22473208
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MZF1 Unknown 23509792
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0001784 Function Phosphotyrosine residue binding IEA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0002042 Process Cell migration involved in sprouting angiogenesis IGI 28341552
GO:0005515 Function Protein binding IPI 16273093, 17500595, 19380743, 20598684, 21706016, 22402981, 24189400, 24658140, 24728074, 25241761, 25814554, 26496610, 28514442, 31515488, 31980649, 32296183, 32606738, 32814053, 33961781, 34591612, 34591642, 35384245
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606076 8981 ENSG00000117461
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92569
Protein name Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55
Protein function Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 358 → 432 SH2 domain Domain
PF00017 SH2 65 → 140 SH2 domain Domain
PF16454 PI3K_P85_iSH2 163 → 331 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
Sequence
Sequence length 461
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
EGFR tyrosine kinase inhibitor resistance GPVI-mediated activation cascade
Endocrine resistance PIP3 activates AKT signaling
Platinum drug resistance Interleukin-7 signaling
ErbB signaling pathway Signaling by SCF-KIT
Ras signaling pathway Synthesis of PIPs at the plasma membrane
Rap1 signaling pathway Constitutive Signaling by Aberrant PI3K in Cancer
cAMP signaling pathway Costimulation by the CD28 family
Chemokine signaling pathway CD28 dependent PI3K/Akt signaling
HIF-1 signaling pathway G alpha (q) signalling events
FoxO signaling pathway Interleukin-3, Interleukin-5 and GM-CSF signaling
Phosphatidylinositol signaling system PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Sphingolipid signaling pathway RET signaling
Phospholipase D signaling pathway Extra-nuclear estrogen signaling
Hormone signaling Interleukin receptor SHC signaling
Autophagy - animal Regulation of signaling by CBL
mTOR signaling pathway  
PI3K-Akt signaling pathway  
AMPK signaling pathway  
Apoptosis  
Longevity regulating pathway  
Longevity regulating pathway - multiple species  
Cellular senescence  
Axon guidance  
VEGF signaling pathway  
Osteoclast differentiation  
Focal adhesion  
Signaling pathways regulating pluripotency of stem cells  
Platelet activation  
Neutrophil extracellular trap formation  
Toll-like receptor signaling pathway  
C-type lectin receptor signaling pathway  
JAK-STAT signaling pathway  
Natural killer cell mediated cytotoxicity  
T cell receptor signaling pathway  
B cell receptor signaling pathway  
Fc epsilon RI signaling pathway  
Fc gamma R-mediated phagocytosis  
TNF signaling pathway  
Leukocyte transendothelial migration  
Neurotrophin signaling pathway  
Cholinergic synapse  
Inflammatory mediator regulation of TRP channels  
Regulation of actin cytoskeleton  
Insulin signaling pathway  
Progesterone-mediated oocyte maturation  
Estrogen signaling pathway  
Prolactin signaling pathway  
Thyroid hormone signaling pathway  
Regulation of lipolysis in adipocytes  
Relaxin signaling pathway  
GnRH secretion  
Type II diabetes mellitus  
Insulin resistance  
Non-alcoholic fatty liver disease  
AGE-RAGE signaling pathway in diabetic complications  
Growth hormone synthesis, secretion and action  
Aldosterone-regulated sodium reabsorption  
Carbohydrate digestion and absorption  
Alzheimer disease  
Spinocerebellar ataxia  
Prion disease  
Bacterial invasion of epithelial cells  
Shigellosis  
Yersinia infection  
Chagas disease  
Amoebiasis  
Hepatitis C  
Hepatitis B  
Measles  
Human cytomegalovirus infection  
Influenza A  
Human papillomavirus infection  
Human T-cell leukemia virus 1 infection  
Kaposi sarcoma-associated herpesvirus infection  
Herpes simplex virus 1 infection  
Epstein-Barr virus infection  
Human immunodeficiency virus 1 infection  
Coronavirus disease - COVID-19  
Pathways in cancer  
Viral carcinogenesis  
Proteoglycans in cancer  
MicroRNAs in cancer  
Chemical carcinogenesis - receptor activation  
Chemical carcinogenesis - reactive oxygen species  
Colorectal cancer  
Renal cell carcinoma  
Pancreatic cancer  
Endometrial cancer  
Glioma  
Prostate cancer  
Melanoma  
Chronic myeloid leukemia  
Acute myeloid leukemia  
Small cell lung cancer  
Non-small cell lung cancer  
Breast cancer  
Hepatocellular carcinoma  
Gastric cancer  
Central carbon metabolism in cancer  
Choline metabolism in cancer  
PD-L1 expression and PD-1 checkpoint pathway in cancer  
Diabetic cardiomyopathy  
Lipid and atherosclerosis  
Fluid shear stress and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
Familial cancer of breast Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEARING LOSS — GWAS catalog 36788145, 37165447, 39024449
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (95)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 2243505
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25371235
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 22982105 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 29535371
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28341552
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 16947419
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 28341552
★★★★★
★☆☆☆☆
Found in Text Mining only
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 30900311
★★★★★
★☆☆☆☆
Found in Text Mining only
Blast Phase Blast phase chronic myelogenous leukemia BEFREE 10071076
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 34321458 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only