Gene Gene information from NCBI Gene database.
Entrez ID 8503
Gene name Phosphoinositide-3-kinase regulatory subunit 3
Gene symbol PIK3R3
Synonyms (NCBI Gene)
p55p55-GAMMAp55PIK
Chromosome 1
Chromosome location 1p34.1
Summary Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene
miRNA miRNA information provided by mirtarbase database.
757
miRTarBase ID miRNA Experiments Reference
MIRT043293 hsa-miR-331-3p CLASH 23622248
MIRT042712 hsa-miR-346 CLASH 23622248
MIRT040803 hsa-miR-18a-3p CLASH 23622248
MIRT053541 hsa-miR-7-5p ELISALuciferase reporter assayqRT-PCRWestern blot 23135998
MIRT726939 hsa-miR-19a-3p HITS-CLIP 22473208
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MZF1 Unknown 23509792
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0001784 Function Phosphotyrosine residue binding IEA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0002042 Process Cell migration involved in sprouting angiogenesis IGI 28341552
GO:0005515 Function Protein binding IPI 16273093, 17500595, 19380743, 20598684, 21706016, 22402981, 24189400, 24658140, 24728074, 25241761, 25814554, 26496610, 28514442, 31515488, 31980649, 32296183, 32606738, 32814053, 33961781, 34591612, 34591642, 35384245
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606076 8981 ENSG00000117461
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92569
Protein name Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55
Protein function Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 65 140 SH2 domain Domain
PF16454 PI3K_P85_iSH2 163 331 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Domain
PF00017 SH2 358 432 SH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
Sequence
Sequence length 461
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Familial cancer of breast Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEARING LOSS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 2243505
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25371235
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 22982105 Associate
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 29535371
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28341552
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 16947419
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 28341552
★☆☆☆☆
Found in Text Mining only
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 30900311
★☆☆☆☆
Found in Text Mining only
Blast Phase Blast phase chronic myelogenous leukemia BEFREE 10071076
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 34321458 Associate
★☆☆☆☆
Found in Text Mining only