PFN3 (profilin 3)

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Gene Gene information from NCBI Gene database.
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Entrez ID 345456
Gene name Profilin 3
Gene symbol PFN3
Synonyms (NCBI Gene)
profilin-3
Chromosome 5
Chromosome location 5q35.3
Summary The product of this gene belongs to the profilin family of proteins. This protein binds to actin and affects the structure of the cytoskeleton. It also may be involved in spermatogenesis. It is a single exon gene. [provided by RefSeq, Jul 2008]
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10 Show/Hide all (10)
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GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IBA
GO:0003779 Function Actin binding IEA
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
612812 18627 ENSG00000196570
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P60673
Protein name Profilin-3 (Profilin III)
Protein function Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylin
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00235 Profilin 2 → 137 Profilin Domain
Tissue specificity TISSUE SPECIFICITY: Testis specific.
Sequence
Sequence length 137
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway
Rap1 signaling pathway
Regulation of actin cytoskeleton
Amyotrophic lateral sclerosis
Shigellosis
Salmonella infection
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PFN4 4 shared pathwaysRap1 signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection Related via 4 shared pathways including Rap1 signaling pathway, Regulation of actin cytoskeleton. PFN2 4 shared pathwaysRap1 signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection Related via 4 shared pathways including Rap1 signaling pathway, Regulation of actin cytoskeleton. PFN1 4 shared pathwaysRap1 signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Salmonella infection Related via 4 shared pathways including Rap1 signaling pathway, Regulation of actin cytoskeleton. ENAH 2 shared pathwaysRap1 signaling pathway, Regulation of actin cytoskeleton Related via 2 shared pathways including Rap1 signaling pathway, Regulation of actin cytoskeleton. MYL10 3 shared pathwaysRegulation of actin cytoskeleton, Shigellosis, Salmonella infection Related via 3 shared pathways including Regulation of actin cytoskeleton, Shigellosis.
Major depressive disorder Linked via 2 of 5 related genesENAH, MYL10 Ocular hypotension Linked via 1 of 5 related genesPFN2 Amyotrophic lateral sclerosis Linked via 1 of 5 related genesPFN1 Esophageal squamous cell carcinoma Linked via 1 of 5 related genesPFN1 amyotrophic lateral sclerosis type 18 Linked via 1 of 5 related genesPFN1