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Gene Gene information from NCBI Gene database.
Entrez ID 84333
Gene name Polycomb group ring finger 5
Gene symbol PCGF5
Synonyms (NCBI Gene)
RNF159
Chromosome 10
Chromosome location 10q23.32
miRNA miRNA information provided by mirtarbase database.
826 Show/Hide all (826)
miRTarBase ID miRNA Experiments Reference
MIRT003815 hsa-miR-373-3p Microarray 15685193
MIRT019923 hsa-miR-375 Microarray 20215506
MIRT003815 hsa-miR-373-3p Microarray 15685193
MIRT024913 hsa-miR-215-5p Microarray 19074876
MIRT026591 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21 Show/Hide all (21)
GO ID Ontology Definition Evidence Reference
GO:0000805 Component X chromosome IEA
GO:0000805 Component X chromosome ISS
GO:0005515 Function Protein binding IPI 19273555, 21282530, 22493164, 23455924, 24981860, 25416956, 25519132, 26496610, 27705803, 28514442, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IDA 21282530
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617407 28264 ENSG00000180628
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86SE9
Protein name Polycomb group RING finger protein 5 (RING finger protein 159)
Protein function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod
PDB 4S3O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 17 → 56 Domain
PF16207 RAWUL 163 → 221 RAWUL domain RING finger- and WD40-associated ubiquitin-like Domain
Sequence
MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQV
HETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKVD
EEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFL
SLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGEN
FRCLNCSASQVCSQDGPLY
QSYPMVLQYRPRIDFG
Sequence length 256
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Polycomb repressive complex RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Signaling pathways regulating pluripotency of stem cells  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Ovarian serous cystadenocarcinoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (7)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Barrett Esophagus Barrett esophagus BEFREE 25228972
★★★★★
★☆☆☆☆
Found in Text Mining only
Barrett Esophagus Barrett esophagus Pubtator 25228972 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Esophageal neoplasm Pubtator 25228972 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Mesothelioma Mesothelioma BEFREE 31570769
★★★★★
★☆☆☆☆
Found in Text Mining only
Mesothelioma Mesothelioma Pubtator 31570769 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Parkinson disease Pubtator 36813848 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Peritonitis Peritonitis Pubtator 31570769 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only