Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	84759
Gene name	Polycomb group ring finger 1
Gene symbol	PCGF1
Synonyms (NCBI Gene)	2010002K04RikNSPC1RNF3A-2RNF68
Chromosome	2
Chromosome location	2p13.1
Summary	PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supp

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044961	hsa-miR-186-5p	CLASH	23622248
MIRT1217386	hsa-miR-23a	CLIP-seq
MIRT1217387	hsa-miR-23b	CLIP-seq
MIRT1217388	hsa-miR-23c	CLIP-seq
MIRT1217389	hsa-miR-3126-3p	CLIP-seq
MIRT1217390	hsa-miR-3150a-3p	CLIP-seq
MIRT1217391	hsa-miR-3175	CLIP-seq
MIRT1217392	hsa-miR-3179	CLIP-seq
MIRT1217393	hsa-miR-3202	CLIP-seq
MIRT1217394	hsa-miR-320a	CLIP-seq
MIRT1217395	hsa-miR-320b	CLIP-seq
MIRT1217396	hsa-miR-320c	CLIP-seq
MIRT1217397	hsa-miR-320d	CLIP-seq
MIRT1217398	hsa-miR-4429	CLIP-seq
MIRT1217399	hsa-miR-4481	CLIP-seq
MIRT1217400	hsa-miR-4667-5p	CLIP-seq
MIRT1217401	hsa-miR-4700-5p	CLIP-seq
MIRT1217402	hsa-miR-4728-5p	CLIP-seq
MIRT1217403	hsa-miR-4745-5p	CLIP-seq
MIRT1217404	hsa-miR-4747-5p	CLIP-seq
MIRT1217405	hsa-miR-579	CLIP-seq
MIRT1217406	hsa-miR-637	CLIP-seq
MIRT1217407	hsa-miR-939	CLIP-seq
MIRT1217386	hsa-miR-23a	CLIP-seq
MIRT1217387	hsa-miR-23b	CLIP-seq
MIRT1217388	hsa-miR-23c	CLIP-seq
MIRT1217389	hsa-miR-3126-3p	CLIP-seq
MIRT1217390	hsa-miR-3150a-3p	CLIP-seq
MIRT1217391	hsa-miR-3175	CLIP-seq
MIRT1217392	hsa-miR-3179	CLIP-seq
MIRT1217393	hsa-miR-3202	CLIP-seq
MIRT1217400	hsa-miR-4667-5p	CLIP-seq
MIRT1217401	hsa-miR-4700-5p	CLIP-seq
MIRT1217402	hsa-miR-4728-5p	CLIP-seq
MIRT1217404	hsa-miR-4747-5p	CLIP-seq
MIRT1217405	hsa-miR-579	CLIP-seq
MIRT1217406	hsa-miR-637	CLIP-seq
MIRT1217407	hsa-miR-939	CLIP-seq
MIRT1217386	hsa-miR-23a	CLIP-seq
MIRT1217387	hsa-miR-23b	CLIP-seq
MIRT1217388	hsa-miR-23c	CLIP-seq
MIRT1217405	hsa-miR-579	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0005515	Function	Protein binding	IPI	16943429, 21282530, 22493164, 23523425, 24981860, 26496610, 26687479, 27505670, 27705803, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	21282530
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006338	Process	Chromatin remodeling	IDA	16943429
GO:0006338	Process	Chromatin remodeling	IMP	26151332
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	26687479
GO:0008270	Function	Zinc ion binding	IEA
GO:0031519	Component	PcG protein complex	IDA	16943429, 21282530, 26151332
GO:0031519	Component	PcG protein complex	IEA
GO:0035102	Component	PRC1 complex	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:1990841	Function	Promoter-specific chromatin binding	IBA

MIM	HGNC	e!Ensembl
610231	17615	ENSG00000115289

Q9BSM1

Protein name

Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)

Protein function

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that

PDB

4HPL , 4HPM , 5JH5 , 8HCU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13923	zf-C3HC4_2	46 → 85		Domain
PF16207	RAWUL	190 → 253	RAWUL domain RING finger- and WD40-associated ubiquitin-like	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11287196}.

Sequence

MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTI
TECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEE
KRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGK
DKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSR
WFGKPSPLLLQYSVKEKRR

Sequence length

259

Interactions

View interactions

KEGG Pathway
Polycomb repressive complex
Signaling pathways regulating pluripotency of stem cells

PCGF1 (polycomb group ring finger 1)

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