Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5066
Gene name	Peptidylglycine alpha-amidating monooxygenase
Gene symbol	PAM
Synonyms (NCBI Gene)	PALPAM-1PHM
Chromosome	5
Chromosome location	5q21.1
Summary	This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PH

109 Show/Hide all (109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047841	hsa-miR-30c-5p	CLASH	23622248
MIRT046087	hsa-miR-125b-5p	CLASH	23622248
MIRT045767	hsa-miR-125a-5p	CLASH	23622248
MIRT440051	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440051	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1211930	hsa-miR-106a	CLIP-seq
MIRT1211931	hsa-miR-106b	CLIP-seq
MIRT1211932	hsa-miR-124	CLIP-seq
MIRT1211933	hsa-miR-1273d	CLIP-seq
MIRT1211934	hsa-miR-132	CLIP-seq
MIRT1211935	hsa-miR-15a	CLIP-seq
MIRT1211936	hsa-miR-15b	CLIP-seq
MIRT1211937	hsa-miR-16	CLIP-seq
MIRT1211938	hsa-miR-17	CLIP-seq
MIRT1211939	hsa-miR-195	CLIP-seq
MIRT1211940	hsa-miR-200b	CLIP-seq
MIRT1211941	hsa-miR-200c	CLIP-seq
MIRT1211942	hsa-miR-20a	CLIP-seq
MIRT1211943	hsa-miR-20b	CLIP-seq
MIRT1211944	hsa-miR-212	CLIP-seq
MIRT1211945	hsa-miR-302a	CLIP-seq
MIRT1211946	hsa-miR-302b	CLIP-seq
MIRT1211947	hsa-miR-302c	CLIP-seq
MIRT1211948	hsa-miR-302d	CLIP-seq
MIRT1211949	hsa-miR-302e	CLIP-seq
MIRT1211950	hsa-miR-3064-3p	CLIP-seq
MIRT1211951	hsa-miR-3128	CLIP-seq
MIRT1211952	hsa-miR-3153	CLIP-seq
MIRT1211953	hsa-miR-372	CLIP-seq
MIRT1211954	hsa-miR-373	CLIP-seq
MIRT1211955	hsa-miR-424	CLIP-seq
MIRT1211956	hsa-miR-4255	CLIP-seq
MIRT1211957	hsa-miR-429	CLIP-seq
MIRT1211958	hsa-miR-4438	CLIP-seq
MIRT1211959	hsa-miR-4524	CLIP-seq
MIRT1211960	hsa-miR-4668-5p	CLIP-seq
MIRT1211961	hsa-miR-4726-3p	CLIP-seq
MIRT1211962	hsa-miR-4753-3p	CLIP-seq
MIRT1211963	hsa-miR-4768-5p	CLIP-seq
MIRT1211964	hsa-miR-497	CLIP-seq
MIRT1211965	hsa-miR-503	CLIP-seq
MIRT1211966	hsa-miR-506	CLIP-seq
MIRT1211967	hsa-miR-519d	CLIP-seq
MIRT1211968	hsa-miR-520a-3p	CLIP-seq
MIRT1211969	hsa-miR-520b	CLIP-seq
MIRT1211970	hsa-miR-520c-3p	CLIP-seq
MIRT1211971	hsa-miR-520d-3p	CLIP-seq
MIRT1211972	hsa-miR-520e	CLIP-seq
MIRT1211973	hsa-miR-548an	CLIP-seq
MIRT1211974	hsa-miR-548c-3p	CLIP-seq
MIRT1211975	hsa-miR-646	CLIP-seq
MIRT1211976	hsa-miR-93	CLIP-seq
MIRT1211977	hsa-miR-3121-3p	CLIP-seq
MIRT1211978	hsa-miR-371-5p	CLIP-seq
MIRT1211979	hsa-miR-371b-5p	CLIP-seq
MIRT1211980	hsa-miR-3976	CLIP-seq
MIRT1211981	hsa-miR-4742-3p	CLIP-seq
MIRT1211982	hsa-miR-4795-3p	CLIP-seq
MIRT1211983	hsa-miR-548t	CLIP-seq
MIRT1211984	hsa-miR-606	CLIP-seq
MIRT1211932	hsa-miR-124	CLIP-seq
MIRT1552035	hsa-miR-4728-3p	CLIP-seq
MIRT1211966	hsa-miR-506	CLIP-seq
MIRT1211973	hsa-miR-548an	CLIP-seq
MIRT2060833	hsa-miR-1305	CLIP-seq
MIRT1211934	hsa-miR-132	CLIP-seq
MIRT2060834	hsa-miR-134	CLIP-seq
MIRT2060835	hsa-miR-205	CLIP-seq
MIRT1211944	hsa-miR-212	CLIP-seq
MIRT2060836	hsa-miR-30a	CLIP-seq
MIRT2060837	hsa-miR-30b	CLIP-seq
MIRT2060838	hsa-miR-30c	CLIP-seq
MIRT2060839	hsa-miR-30d	CLIP-seq
MIRT2060840	hsa-miR-30e	CLIP-seq
MIRT2060841	hsa-miR-3118	CLIP-seq
MIRT1211951	hsa-miR-3128	CLIP-seq
MIRT2060842	hsa-miR-3164	CLIP-seq
MIRT2060843	hsa-miR-3607-3p	CLIP-seq
MIRT2060844	hsa-miR-3686	CLIP-seq
MIRT2060845	hsa-miR-3907	CLIP-seq
MIRT2060846	hsa-miR-4317	CLIP-seq
MIRT2060847	hsa-miR-4318	CLIP-seq
MIRT2060848	hsa-miR-4693-5p	CLIP-seq
MIRT1211981	hsa-miR-4742-3p	CLIP-seq
MIRT1211982	hsa-miR-4795-3p	CLIP-seq
MIRT2060849	hsa-miR-892a	CLIP-seq
MIRT1211930	hsa-miR-106a	CLIP-seq
MIRT1211931	hsa-miR-106b	CLIP-seq
MIRT1211938	hsa-miR-17	CLIP-seq
MIRT1211942	hsa-miR-20a	CLIP-seq
MIRT1211943	hsa-miR-20b	CLIP-seq
MIRT1211967	hsa-miR-519d	CLIP-seq
MIRT1211976	hsa-miR-93	CLIP-seq
MIRT2392079	hsa-miR-1208	CLIP-seq
MIRT2392080	hsa-miR-4496	CLIP-seq
MIRT2392081	hsa-miR-651	CLIP-seq
MIRT2392079	hsa-miR-1208	CLIP-seq
MIRT2392080	hsa-miR-4496	CLIP-seq
MIRT2431874	hsa-miR-4786-3p	CLIP-seq
MIRT2431875	hsa-miR-548ad	CLIP-seq
MIRT2392081	hsa-miR-651	CLIP-seq
MIRT2687044	hsa-miR-330-3p	CLIP-seq
MIRT2687045	hsa-miR-4314	CLIP-seq
MIRT2687046	hsa-miR-4453	CLIP-seq
MIRT2687047	hsa-miR-4538	CLIP-seq
MIRT2687048	hsa-miR-4799-5p	CLIP-seq
MIRT2687049	hsa-miR-550b	CLIP-seq
MIRT2687050	hsa-miR-555	CLIP-seq
MIRT2687051	hsa-miR-888	CLIP-seq

35 Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001519	Process	Peptide amidation	IDA	2357221, 12699694
GO:0003824	Function	Catalytic activity	IEA
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004504	Function	Peptidylglycine monooxygenase activity	IBA
GO:0004504	Function	Peptidylglycine monooxygenase activity	IDA	2357221, 12699694
GO:0004504	Function	Peptidylglycine monooxygenase activity	IEA
GO:0004598	Function	Peptidylamidoglycolate lyase activity	IDA	12699694
GO:0004598	Function	Peptidylamidoglycolate lyase activity	IEA
GO:0004598	Function	Peptidylamidoglycolate lyase activity	ISS
GO:0005507	Function	Copper ion binding	IEA
GO:0005507	Function	Copper ion binding	ISS
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0006518	Process	Peptide metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IDA	12699694
GO:0010043	Process	Response to zinc ion	IDA	12699694
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016715	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031418	Function	L-ascorbic acid binding	IEA
GO:0034599	Process	Cellular response to oxidative stress	IC	39880951
GO:0034599	Process	Cellular response to oxidative stress	IC	39880951
GO:0034599	Process	Cellular response to oxidative stress	IDA	39880951
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	39880951
GO:0046872	Function	Metal ion binding	IEA
GO:0062112	Process	Fatty acid primary amide biosynthetic process	ISS
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145

MIM	HGNC	e!Ensembl
170270	8596	ENSG00000145730

P19021

Protein name

Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]

Protein function

Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:12699694, PubMed:2357221). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (PubMed:15

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01082	Cu2_monooxygen	59 → 175	Copper type II ascorbate-dependent monooxygenase, N-terminal domain	Domain
PF01436	NHL	630 → 659	NHL repeat	Repeat
PF01436	NHL	683 → 711	NHL repeat	Repeat
PF01436	NHL	779 → 806	NHL repeat	Repeat
PF03712	Cu2_monoox_C	195 → 342	Copper type II ascorbate-dependent monooxygenase, C-terminal domain	Domain

Sequence

MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALD
IRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF
CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKD
CSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH
LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATH
IGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE
HHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESES
DLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQ
PPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSF
DSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALH
QVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFS
PSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVR
EIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFD
MPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMEN
KPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEH
KLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEE
YSAPLPALAPSSS

Sequence length

973

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (15)
ANDROGENETIC ALOPECIA	—	GWAS catalog	30573740	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDERS	—	CTD, Disgenet CTD, Disgenet	19815072	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	34737426, 39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 2	—	CTD	24464100, 30054598	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign; Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	30804565, 35835914	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	28892059, 31701892	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	38839884	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	36329495	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	19815072	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	29632382, 30054458, 30297969, 30595370, 34594039, 35551307, 36329495, 38374256, 38685053, 39024449, 39379762	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PAM (peptidylglycine alpha-amidating monooxygenase)

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