PABPN1L (PABPN1 like, cytoplasmic)

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Gene Gene information from NCBI Gene database.
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Entrez ID 390748
Gene name PABPN1 like, cytoplasmic
Gene symbol PABPN1L
Synonyms (NCBI Gene)
PABPNL1ePABP2
Chromosome 16
Chromosome location 16q24.3
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT527028 hsa-miR-4323 PAR-CLIP 22012620
MIRT527027 hsa-miR-2392 PAR-CLIP 22012620
MIRT527026 hsa-miR-6840-3p PAR-CLIP 22012620
MIRT527025 hsa-miR-6752-3p PAR-CLIP 22012620
MIRT527024 hsa-miR-7113-3p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding IEA
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A6NDY0
Protein name Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1)
Protein function Binds the poly(A) tail of mRNA.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 149 → 218 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in various adult tissues. {ECO:0000269|PubMed:18483763}.
Sequence 
MWPFPSRSLFPPPTQAWLQTVSSDPEAQGWGAWNETKEILGPEGGEGKEEKEEEEDAEED
QDGDAGFLLSLLEQENLAECPLPDQELEAIKMKVCAMEQAEGTPRPPGVQQQAEEEEGTA
AGQLLSPETVGCPLSGTPEEKVEADHRSVYVGNVDYGGSAEELEAHFSRCGEVHRVTILC
DKFSGHPKGYAYIEFATKGSVQAAVELDQSLFRGRVIKVLPKRTNFPGISSTDRGGLRGH
PGSRGAPFPHSGLQGRPRLRPQGQNRARGKFSPWFSPY
Sequence length 278
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway
mRNA surveillance pathway
Influenza A
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
PARKINSON DISEASE — GWAS catalog 25663231
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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BCL2L2-PABPN1 2 shared pathwaysmRNA surveillance pathway, Influenza A Related via 2 shared pathways including mRNA surveillance pathway, Influenza A. CPSF4L 2 shared pathwaysmRNA surveillance pathway, Influenza A Related via 2 shared pathways including mRNA surveillance pathway, Influenza A. NXT2 2 shared pathwaysmRNA surveillance pathway, Influenza A Related via 2 shared pathways including mRNA surveillance pathway, Influenza A. NXT1 2 shared pathwaysmRNA surveillance pathway, Influenza A Related via 2 shared pathways including mRNA surveillance pathway, Influenza A. NXF3 2 shared pathwaysmRNA surveillance pathway, Influenza A Related via 2 shared pathways including mRNA surveillance pathway, Influenza A.
Male infertility Linked via 2 of 5 related genesNXT2, NXF3 Prostate cancer Linked via 1 of 5 related genesBCL2L2-PABPN1