Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	57523
Gene name	NYN domain and retroviral integrase containing
Gene symbol	NYNRIN
Synonyms (NCBI Gene)	CGIN1KIAA1305
Chromosome	14
Chromosome location	14q12

130 Show/Hide all (130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042292	hsa-miR-484	CLASH	23622248
MIRT1200825	hsa-miR-1227	CLIP-seq
MIRT1200826	hsa-miR-1228	CLIP-seq
MIRT1200827	hsa-miR-1245b-3p	CLIP-seq
MIRT1200828	hsa-miR-1252	CLIP-seq
MIRT1200829	hsa-miR-1270	CLIP-seq
MIRT1200830	hsa-miR-1271	CLIP-seq
MIRT1200831	hsa-miR-1292	CLIP-seq
MIRT1200832	hsa-miR-1321	CLIP-seq
MIRT1200833	hsa-miR-182	CLIP-seq
MIRT1200834	hsa-miR-185	CLIP-seq
MIRT1200835	hsa-miR-1909	CLIP-seq
MIRT1200836	hsa-miR-1914	CLIP-seq
MIRT1200837	hsa-miR-219-2-3p	CLIP-seq
MIRT1200838	hsa-miR-2277-3p	CLIP-seq
MIRT1200839	hsa-miR-2467-5p	CLIP-seq
MIRT1200840	hsa-miR-299-3p	CLIP-seq
MIRT1200841	hsa-miR-29a	CLIP-seq
MIRT1200842	hsa-miR-29b	CLIP-seq
MIRT1200843	hsa-miR-29c	CLIP-seq
MIRT1200844	hsa-miR-3065-3p	CLIP-seq
MIRT1200845	hsa-miR-3120-3p	CLIP-seq
MIRT1200846	hsa-miR-3123	CLIP-seq
MIRT1200847	hsa-miR-3151	CLIP-seq
MIRT1200848	hsa-miR-3166	CLIP-seq
MIRT1200849	hsa-miR-3188	CLIP-seq
MIRT1200850	hsa-miR-3200-5p	CLIP-seq
MIRT1200851	hsa-miR-3202	CLIP-seq
MIRT1200852	hsa-miR-329	CLIP-seq
MIRT1200853	hsa-miR-330-3p	CLIP-seq
MIRT1200854	hsa-miR-342-3p	CLIP-seq
MIRT1200855	hsa-miR-3591-3p	CLIP-seq
MIRT1200856	hsa-miR-362-3p	CLIP-seq
MIRT1200857	hsa-miR-362-5p	CLIP-seq
MIRT1200858	hsa-miR-3652	CLIP-seq
MIRT1200859	hsa-miR-3660	CLIP-seq
MIRT1200860	hsa-miR-3663-5p	CLIP-seq
MIRT1200861	hsa-miR-3678-3p	CLIP-seq
MIRT1200862	hsa-miR-3680	CLIP-seq
MIRT1200863	hsa-miR-377	CLIP-seq
MIRT1200864	hsa-miR-3912	CLIP-seq
MIRT1200865	hsa-miR-3975	CLIP-seq
MIRT1200866	hsa-miR-4252	CLIP-seq
MIRT1200867	hsa-miR-4270	CLIP-seq
MIRT1200868	hsa-miR-4306	CLIP-seq
MIRT1200869	hsa-miR-4316	CLIP-seq
MIRT1200870	hsa-miR-4419a	CLIP-seq
MIRT1200871	hsa-miR-4430	CLIP-seq
MIRT1200872	hsa-miR-4441	CLIP-seq
MIRT1200873	hsa-miR-4447	CLIP-seq
MIRT1200874	hsa-miR-4455	CLIP-seq
MIRT1200875	hsa-miR-4470	CLIP-seq
MIRT1200876	hsa-miR-4472	CLIP-seq
MIRT1200877	hsa-miR-4510	CLIP-seq
MIRT1200878	hsa-miR-4526	CLIP-seq
MIRT1200879	hsa-miR-4531	CLIP-seq
MIRT1200880	hsa-miR-4533	CLIP-seq
MIRT1200881	hsa-miR-4638-3p	CLIP-seq
MIRT1200882	hsa-miR-4644	CLIP-seq
MIRT1200883	hsa-miR-4684-3p	CLIP-seq
MIRT1200884	hsa-miR-4693-3p	CLIP-seq
MIRT1200885	hsa-miR-4700-3p	CLIP-seq
MIRT1200886	hsa-miR-4705	CLIP-seq
MIRT1200887	hsa-miR-4709-3p	CLIP-seq
MIRT1200888	hsa-miR-4716-3p	CLIP-seq
MIRT1200889	hsa-miR-4728-5p	CLIP-seq
MIRT1200890	hsa-miR-4733-3p	CLIP-seq
MIRT1200891	hsa-miR-4739	CLIP-seq
MIRT1200892	hsa-miR-4756-5p	CLIP-seq
MIRT1200893	hsa-miR-4771	CLIP-seq
MIRT1200894	hsa-miR-4787-5p	CLIP-seq
MIRT1200895	hsa-miR-4797-5p	CLIP-seq
MIRT1200896	hsa-miR-483-3p	CLIP-seq
MIRT1200897	hsa-miR-485-5p	CLIP-seq
MIRT1200898	hsa-miR-491-5p	CLIP-seq
MIRT1200899	hsa-miR-500a	CLIP-seq
MIRT1200900	hsa-miR-500b	CLIP-seq
MIRT1200901	hsa-miR-505	CLIP-seq
MIRT1200902	hsa-miR-571	CLIP-seq
MIRT1200903	hsa-miR-609	CLIP-seq
MIRT1200904	hsa-miR-615-5p	CLIP-seq
MIRT1200905	hsa-miR-619	CLIP-seq
MIRT1200906	hsa-miR-620	CLIP-seq
MIRT1200907	hsa-miR-625	CLIP-seq
MIRT1200908	hsa-miR-873	CLIP-seq
MIRT1200909	hsa-miR-885-5p	CLIP-seq
MIRT1200910	hsa-miR-96	CLIP-seq
MIRT2058067	hsa-miR-3189-3p	CLIP-seq
MIRT2058068	hsa-miR-502-5p	CLIP-seq
MIRT2058069	hsa-miR-885-3p	CLIP-seq
MIRT1200826	hsa-miR-1228	CLIP-seq
MIRT2286485	hsa-miR-1238	CLIP-seq
MIRT2286486	hsa-miR-3124-3p	CLIP-seq
MIRT2286487	hsa-miR-3607-3p	CLIP-seq
MIRT2286488	hsa-miR-4677-3p	CLIP-seq
MIRT2286489	hsa-miR-4718	CLIP-seq
MIRT2286490	hsa-miR-515-5p	CLIP-seq
MIRT2431782	hsa-miR-105	CLIP-seq
MIRT2431783	hsa-miR-3154	CLIP-seq
MIRT2431784	hsa-miR-3646	CLIP-seq
MIRT1200869	hsa-miR-4316	CLIP-seq
MIRT2686733	hsa-miR-1294	CLIP-seq
MIRT2686734	hsa-miR-186	CLIP-seq
MIRT2686735	hsa-miR-2276	CLIP-seq
MIRT2686736	hsa-miR-3126-5p	CLIP-seq
MIRT2686737	hsa-miR-3176	CLIP-seq
MIRT2686738	hsa-miR-3622a-3p	CLIP-seq
MIRT2686739	hsa-miR-3622b-3p	CLIP-seq
MIRT1200862	hsa-miR-3680	CLIP-seq
MIRT2686740	hsa-miR-3714	CLIP-seq
MIRT2686741	hsa-miR-3922-3p	CLIP-seq
MIRT2686742	hsa-miR-412	CLIP-seq
MIRT2686743	hsa-miR-4254	CLIP-seq
MIRT1200869	hsa-miR-4316	CLIP-seq
MIRT1200870	hsa-miR-4419a	CLIP-seq
MIRT1200877	hsa-miR-4510	CLIP-seq
MIRT2686744	hsa-miR-4672	CLIP-seq
MIRT2286488	hsa-miR-4677-3p	CLIP-seq
MIRT2686745	hsa-miR-4687-3p	CLIP-seq
MIRT2686746	hsa-miR-4695-3p	CLIP-seq
MIRT1200885	hsa-miR-4700-3p	CLIP-seq
MIRT2686747	hsa-miR-4708-3p	CLIP-seq
MIRT2686748	hsa-miR-4736	CLIP-seq
MIRT2686749	hsa-miR-4772-3p	CLIP-seq
MIRT2686750	hsa-miR-518a-5p	CLIP-seq
MIRT2686751	hsa-miR-527	CLIP-seq
MIRT1200905	hsa-miR-619	CLIP-seq
MIRT2686752	hsa-miR-629	CLIP-seq
MIRT2686753	hsa-miR-661	CLIP-seq
MIRT2686754	hsa-miR-940	CLIP-seq

13 Show/Hide all (13)

GO ID	Ontology	Definition	Evidence
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0003674	Function	Molecular_function	ND
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IBA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0008150	Process	Biological_process	ND
GO:0015074	Process	DNA integration	IEA
GO:0016020	Component	Membrane	IEA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IBA

MIM	HGNC	e!Ensembl
620129	20165	ENSG00000205978

Q9P2P1

Protein name

Protein NYNRIN (NYN domain and retroviral integrase catalytic domain-containing protein) (Protein cousin of GIN1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11977	RNase_Zc3h12a	791 → 942	Zc3h12a-like Ribonuclease NYN domain	Domain
PF17919	RT_RNaseH_2	1130 → 1230	RNase H-like domain found in reverse transcriptase	Domain
PF17921	Integrase_H2C2	1536 → 1593	Integrase zinc binding domain	Domain

Sequence

MLLSGGDPPAQEWFMVQTKSKPRVQRQRLQVQRIFRVKLNAFQSRPDTPYFWLQLEGPRE
NMGKAKEYLKGLCSPELWKEVRYPPILHCAFLGAQGLFLDCLCWSTLAYLVPGPPGSLMV
GGLTESFIMTQNWLEELVGRLRWGPAPLLTPRGIWEAEVTRAFGALVWIRGDQHAGDLLQ
LPPAVQELLLSLVRDAAGKEDIIEWLSRFGISDSHSDPEVLICPPQQQKEAPAMVSVGES
PGPFVDMGTLQNRGPENSKRLSSLGATGSLITAQSTPQEAANQLVRVGSNNQDGMDSAQE
EGTVQATSSQDSTNHTQALLKQRQVQKIEDKLLFQPPVSALGVCPPWKAWTPGPAFGPLW
PGAIAATFWRINELHSLHLAWLLSQACFNFPFWQRPLGPIQLKLPGQNPLPLNLEWKQKE
LAPLPSAESPAGRPDGGLGGEAALQNCPRPEISPKVTSLLVVPGSSDVKDKVSSDLPQIG
PPLTSTPQLQAGGEPGDQGSMQLDFKGLEEGPAPVLPTGQGKPVAQGGLTDQSVPGAQTV
PETLKVPMAAAVPKAENPSRTQVPSAAPKLPTSRMMLAVHTEPAAPEVPLAPTKPTAQLM
ATAQKTVVNQPVLVAQVEPTTPKTPQAQKMPVAKTSPAGPKTPKAQAGPAATVSKAPAAS
KAPAAPKVPVTPRVSRAPKTPAAQKVPTDAGPTLDVARLLSEVQPTSRASVSLLKGQGQA
GRQGPQSSGTLALSSKHQFQMEGLLGAWEGAPRQPPRHLQANSTVTSFQRYHEALNTPFE
LNLSGEPGNQGLRRVVIDGSSVAMVHGLQHFFSCRGIAMAVQFFWNRGHREVTVFVPTWQ
LKKNRRVRESHFLTKLHSLKMLSITPSQLENGKKITTYDYRFMVKLAEETDGIIVTNEQI
HILMNSSKKLMVKDRLLPFTFAGNLFMVPDDPLGRDGPTLDEFLKKPNRLDTDIGNFLKV
WKTLPPSSASVTELSDDADSGPLESLPNMEEVREEKEERQDEEQRQGQGTQKAAEEDDLD
SSLASVFRVECPSLSEEILRCLSLHDPPDGALDIDLLPGAASPYLGIPWDGKAPCQQVLA
HLAQLTIPSNFTALSFFMGFMDSHRDAIPDYEALVGPLHSLLKQKPDWQWDQEHEEAFLA
LKRALVSALCLMAPNSQLPFRLEVTVSHVALTAILHQEHSGRKHPIAYTSKPLLPDEESQ
GPQSGGDSPYAVAWALKHFSRCIGDTPVVLDLSYASRTTADPEVREGRRVSKAWLIRWSL
LVQDKGKRALELALLQGLLGENRLLTPAASMPRFFQVLPPFSDLSTFVCIHMSGYCFYRE
DEWCAGFGLYVLSPTSPPVSLSFSCSPYTPTYAHLAAVACGLERFGQSPLPVVFLTHCNW
IFSLLWELLPLWRARGFLSSDGAPLPHPSLLSYIISLTSGLSSLPFIYRTSYRGSLFAVT
VDTLAKQGAQGGGQWWSLPKDVPAPTVSPHAMGKRPNLLALQLSDSTLADIIARLQAGQK
LSGSSPFSSAFNSLSLDKESGLLMFKGDKKPRVWVVPTQLRRDLIFSVHDIPLGAHQRPE
ETYKKLRLLGWWPGMQEHVKDYCRSCLFCIPRNLIGSELKVIESPWPLRSTAPWSNLQIE
VVGPVTISEEGHKHVLIVADPNTRWVEAFPLKPYTHTAVAQVLLQHVFARWGVPVRLEAA
QGPQFARHVLVSCGLALGAQVASLSRDLQFPCLTSSGAYWEFKRALKEFIFLHGKKWAAS
LPLLHLAFRASSTDATPFKVLTGGESRLTEPLWWEMSSANIEGLKMDVFLLQLVGELLEL
HWRVADKASEKAENRRFKRESQEKEWNVGDQVLLLSLPRNGSSAKWVGPFYIGDRLSLSL
YRIWGFPTPEKLGCIYPSSLMKAFAKSGTPLSFKVLEQ

Sequence length

1898

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (16)
Cervical cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	38965376	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatoblastoma	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOGONADISM	—	GWAS catalog	40316537	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	GWAS catalog	35131881	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NYNRIN-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Predisposition to Wilms tumor	Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	29930801	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	32499647, 38374256	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Wilms Tumor	Wilms tumor	Pubtator	30885698, 38110397	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NYNRIN (NYN domain and retroviral integrase containing)

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