Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4759
Gene name	Neuraminidase 2
Gene symbol	NEU2
Synonyms (NCBI Gene)	SIAL2
Chromosome	2
Chromosome location	2q37.1
Summary	This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonst

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004308	Function	Exo-alpha-sialidase activity	IBA
GO:0004308	Function	Exo-alpha-sialidase activity	IDA	14613940, 22228546, 26193330
GO:0004308	Function	Exo-alpha-sialidase activity	IEA
GO:0004308	Function	Exo-alpha-sialidase activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 26193330, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8253770
GO:0005764	Component	Lysosome	IBA
GO:0005829	Component	Cytosol	IDA	10561456, 26193330
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006516	Process	Glycoprotein catabolic process	IDA	14613940
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006689	Process	Ganglioside catabolic process	IBA
GO:0006689	Process	Ganglioside catabolic process	IDA	14613940, 22228546
GO:0006689	Process	Ganglioside catabolic process	IEA
GO:0009313	Process	Oligosaccharide catabolic process	IBA
GO:0009313	Process	Oligosaccharide catabolic process	IDA	14613940, 22228546, 26193330
GO:0009313	Process	Oligosaccharide catabolic process	IEA
GO:0016020	Component	Membrane	IBA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0046479	Process	Glycosphingolipid catabolic process	TAS
GO:1902494	Component	Catalytic complex	IDA	26193330

MIM	HGNC	e!Ensembl
605528	7759	ENSG00000115488

Q9Y3R4

Protein name

Sialidase-2 (EC 3.2.1.18) (Cytosolic sialidase) (N-acetyl-alpha-neuraminidase 2)

Protein function

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546). R

PDB

1SNT , 1SO7 , 1VCU , 2F0Z , 2F10 , 2F11 , 2F12 , 2F13 , 2F24 , 2F25 , 2F26 , 2F27 , 2F28 , 2F29 , 4NC5 , 4NCS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13088	BNR_2	32 → 346	BNR repeat-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1. {ECO:0000269|PubMed:10191093}.

Sequence

MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYD
APTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRAN
VTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYA
YRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHL
RARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTH
SWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYE
EIVFLMFTLKQAFPAEYLPQ

Sequence length

380

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Other glycan degradation	Glycosphingolipid metabolism
Sphingolipid metabolism	Sialic acid metabolism
Metabolic pathways

NEU2 (neuraminidase 2)

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