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Gene Gene information from NCBI Gene database.
Entrez ID 22916
Gene name Nuclear cap binding protein subunit 2
Gene symbol NCBP2
Synonyms (NCBI Gene)
CBC2CBP20NIP1PIG55
Chromosome 3
Chromosome location 3q29
Summary The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5` cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and co
miRNA miRNA information provided by mirtarbase database.
524 Show/Hide all (524)
miRTarBase ID miRNA Experiments Reference
MIRT025377 hsa-miR-34a-5p Sequencing 20371350
MIRT026313 hsa-miR-192-5p Sequencing 20371350
MIRT030403 hsa-miR-24-3p Microarray 19748357
MIRT050630 hsa-miR-19b-3p CLASH 23622248
MIRT038675 hsa-miR-10a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
58 Show/Hide all (58)
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 11551508
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 17873884, 18369367
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS 16186820
GO:0000339 Function RNA cap binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605133 7659 ENSG00000114503
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52298
Protein name Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)
Protein function Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silen
PDB 1H2T , 1H2U , 1H2V , 1H6K , 1N52 , 1N54 , 3FEX , 3FEY , 5OO6 , 5OOB , 6D0Y , 7ABG , 8BY6 , 8PMP , 8PNT , 8SRR , 8SUY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 42 → 112 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Sequence
MSGGLLKALRSDSYVELSQYRDQHFRGDNEEQEKLLKKSCTLYVGNLSFYTTEEQIYELF
SKSGDIKKIIMGLDKMKKTACGFCFVEYYSRADAENAMRYINGTRLDDRIIR
TDWDAGFK
EGRQYGRGRSGGQVRDEYRQDYDAGRGGYGKLAQNQ
Sequence length 156
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Nucleocytoplasmic transport SLBP independent Processing of Histone Pre-mRNAs
mRNA surveillance pathway Formation of RNA Pol II elongation complex
Spliceosome Formation of the Early Elongation Complex
  Transport of the SLBP independent Mature mRNA
  Transport of the SLBP Dependant Mature mRNA
  Transport of Mature mRNA Derived from an Intronless Transcript
  Transport of Mature mRNA derived from an Intron-Containing Transcript
  snRNP Assembly
  RNA Polymerase II Pre-transcription Events
  FGFR2 alternative splicing
  RNA polymerase II transcribes snRNA genes
  mRNA Capping
  mRNA Splicing - Major Pathway
  mRNA Splicing - Minor Pathway
  mRNA 3'-end processing
  Processing of Capped Intron-Containing Pre-mRNA
  RNA Polymerase II Transcription Termination
  SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
  Processing of Intronless Pre-mRNAs
  Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
  Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)