Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	55110
Gene name	Mago homolog B, exon junction complex subunit
Gene symbol	MAGOHB
Synonyms (NCBI Gene)	MGN2magomagoh
Chromosome	12
Chromosome location	12p13.2

111 Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050618	hsa-miR-20a-5p	CLASH	23622248
MIRT1126077	hsa-miR-1208	CLIP-seq
MIRT1126078	hsa-miR-140-5p	CLIP-seq
MIRT1126079	hsa-miR-148a	CLIP-seq
MIRT1126080	hsa-miR-148b	CLIP-seq
MIRT1126081	hsa-miR-152	CLIP-seq
MIRT1126082	hsa-miR-153	CLIP-seq
MIRT1126083	hsa-miR-181a	CLIP-seq
MIRT1126084	hsa-miR-181b	CLIP-seq
MIRT1126085	hsa-miR-181c	CLIP-seq
MIRT1126086	hsa-miR-181d	CLIP-seq
MIRT1126087	hsa-miR-23a	CLIP-seq
MIRT1126088	hsa-miR-23b	CLIP-seq
MIRT1126089	hsa-miR-23c	CLIP-seq
MIRT1126090	hsa-miR-29a	CLIP-seq
MIRT1126091	hsa-miR-29b	CLIP-seq
MIRT1126092	hsa-miR-29c	CLIP-seq
MIRT1126093	hsa-miR-3120-3p	CLIP-seq
MIRT1126094	hsa-miR-3121-3p	CLIP-seq
MIRT1126095	hsa-miR-3182	CLIP-seq
MIRT1126096	hsa-miR-3616-5p	CLIP-seq
MIRT1126097	hsa-miR-3647-5p	CLIP-seq
MIRT1126098	hsa-miR-3936	CLIP-seq
MIRT1126099	hsa-miR-3977	CLIP-seq
MIRT1126100	hsa-miR-4262	CLIP-seq
MIRT1126101	hsa-miR-4263	CLIP-seq
MIRT1126102	hsa-miR-4276	CLIP-seq
MIRT1126103	hsa-miR-4328	CLIP-seq
MIRT1126104	hsa-miR-448	CLIP-seq
MIRT1126105	hsa-miR-455-3p	CLIP-seq
MIRT1126106	hsa-miR-4697-3p	CLIP-seq
MIRT1126107	hsa-miR-4795-5p	CLIP-seq
MIRT1126108	hsa-miR-513a-5p	CLIP-seq
MIRT1126109	hsa-miR-548ac	CLIP-seq
MIRT1126110	hsa-miR-548ae	CLIP-seq
MIRT1126111	hsa-miR-548aj	CLIP-seq
MIRT1126112	hsa-miR-548am	CLIP-seq
MIRT1126113	hsa-miR-548d-3p	CLIP-seq
MIRT1126114	hsa-miR-548x	CLIP-seq
MIRT1126115	hsa-miR-548z	CLIP-seq
MIRT1126116	hsa-miR-573	CLIP-seq
MIRT1126117	hsa-miR-576-5p	CLIP-seq
MIRT1126118	hsa-miR-600	CLIP-seq
MIRT1126119	hsa-miR-767-5p	CLIP-seq
MIRT1126120	hsa-miR-944	CLIP-seq
MIRT2266096	hsa-miR-101	CLIP-seq
MIRT2266097	hsa-miR-1228	CLIP-seq
MIRT2266098	hsa-miR-124	CLIP-seq
MIRT2266099	hsa-miR-1245b-5p	CLIP-seq
MIRT2266100	hsa-miR-1255a	CLIP-seq
MIRT2266101	hsa-miR-1255b	CLIP-seq
MIRT2266102	hsa-miR-1273d	CLIP-seq
MIRT2266103	hsa-miR-1297	CLIP-seq
MIRT2266104	hsa-miR-1303	CLIP-seq
MIRT2266105	hsa-miR-1324	CLIP-seq
MIRT2266106	hsa-miR-199a-3p	CLIP-seq
MIRT2266107	hsa-miR-199b-3p	CLIP-seq
MIRT2266108	hsa-miR-26a	CLIP-seq
MIRT2266109	hsa-miR-26b	CLIP-seq
MIRT2266110	hsa-miR-300	CLIP-seq
MIRT2266111	hsa-miR-3123	CLIP-seq
MIRT2266112	hsa-miR-3129-5p	CLIP-seq
MIRT2266113	hsa-miR-3142	CLIP-seq
MIRT2266114	hsa-miR-3144-5p	CLIP-seq
MIRT2266115	hsa-miR-3148	CLIP-seq
MIRT2266116	hsa-miR-3151	CLIP-seq
MIRT2266117	hsa-miR-3166	CLIP-seq
MIRT2266118	hsa-miR-3191	CLIP-seq
MIRT2266119	hsa-miR-3199	CLIP-seq
MIRT2266120	hsa-miR-381	CLIP-seq
MIRT2266121	hsa-miR-3920	CLIP-seq
MIRT2266122	hsa-miR-3925-5p	CLIP-seq
MIRT2266123	hsa-miR-3978	CLIP-seq
MIRT2266124	hsa-miR-4293	CLIP-seq
MIRT2266125	hsa-miR-4305	CLIP-seq
MIRT1126103	hsa-miR-4328	CLIP-seq
MIRT2266126	hsa-miR-4447	CLIP-seq
MIRT2266127	hsa-miR-4465	CLIP-seq
MIRT2266128	hsa-miR-4472	CLIP-seq
MIRT2266129	hsa-miR-4645-3p	CLIP-seq
MIRT2266130	hsa-miR-4652-5p	CLIP-seq
MIRT2266131	hsa-miR-4654	CLIP-seq
MIRT2266132	hsa-miR-4666-3p	CLIP-seq
MIRT2266133	hsa-miR-4670-3p	CLIP-seq
MIRT2266134	hsa-miR-4769-5p	CLIP-seq
MIRT2266135	hsa-miR-4771	CLIP-seq
MIRT2266136	hsa-miR-4789-5p	CLIP-seq
MIRT2266137	hsa-miR-491-5p	CLIP-seq
MIRT2266138	hsa-miR-506	CLIP-seq
MIRT2266139	hsa-miR-512-5p	CLIP-seq
MIRT2266140	hsa-miR-553	CLIP-seq
MIRT2266141	hsa-miR-579	CLIP-seq
MIRT2266142	hsa-miR-624	CLIP-seq
MIRT2266143	hsa-miR-890	CLIP-seq
MIRT2266144	hsa-miR-936	CLIP-seq
MIRT2390466	hsa-miR-1243	CLIP-seq
MIRT2390467	hsa-miR-2861	CLIP-seq
MIRT2390468	hsa-miR-3654	CLIP-seq
MIRT2390469	hsa-miR-4265	CLIP-seq
MIRT2390470	hsa-miR-4296	CLIP-seq
MIRT2390471	hsa-miR-4318	CLIP-seq
MIRT2390472	hsa-miR-4322	CLIP-seq
MIRT2390473	hsa-miR-4417	CLIP-seq
MIRT2453619	hsa-miR-3973	CLIP-seq
MIRT2453620	hsa-miR-520g	CLIP-seq
MIRT2453621	hsa-miR-520h	CLIP-seq
MIRT2453622	hsa-miR-548l	CLIP-seq
MIRT2453619	hsa-miR-3973	CLIP-seq
MIRT2453620	hsa-miR-520g	CLIP-seq
MIRT2453621	hsa-miR-520h	CLIP-seq
MIRT2453622	hsa-miR-548l	CLIP-seq

30 Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI	23917022
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28502770
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21044950, 21516116, 25416956, 26496610, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	28502770
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21289489
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005829	Component	Cytosol	NAS	21289489
GO:0006397	Process	MRNA processing	IEA
GO:0006406	Process	MRNA export from nucleus	NAS	11532962
GO:0008380	Process	RNA splicing	IBA
GO:0008380	Process	RNA splicing	IEA
GO:0035145	Component	Exon-exon junction complex	IBA
GO:0035145	Component	Exon-exon junction complex	IDA	23917022
GO:0035145	Component	Exon-exon junction complex	IEA
GO:0035145	Component	Exon-exon junction complex	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0050684	Process	Regulation of mRNA processing	ISS
GO:0051028	Process	MRNA transport	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28502770
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IDA	29301961
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:1990501	Component	Exon-exon junction subcomplex mago-y14	IEA
GO:1990501	Component	Exon-exon junction subcomplex mago-y14	IPI	25416956
GO:2000622	Process	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISS

MIM	HGNC	e!Ensembl
619552	25504	ENSG00000111196

Q96A72

Protein name

Protein mago nashi homolog 2

Protein function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961, PubMed:30705154). Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022)

PDB

5XJC , 5YZG , 6ICZ , 6QDV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02792	Mago_nashi	7 → 148	Mago nashi protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVME
ELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEG
LRVFYYLVQDLKCLVFSLIGLHFKIKPI

Sequence length

148

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Nucleocytoplasmic transport	Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA surveillance pathway	mRNA Splicing - Major Pathway
Spliceosome	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OVARIAN CYSTS	—	CTD	21239663	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (13)
Brain Neoplasms	Brain neoplasms	Pubtator	37294214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28263985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	18360708	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Corpus Luteum Cyst	Corpus Luteum Cyst	CTD_human_DG	21239663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	37294214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37294214, 37390121	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	12821948		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29955178		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36497117	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	36497117	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Cysts	Ovarian Cysts	CTD_human_DG	21239663		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	38268030	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
MAGOH	[]	8	["Nucleocytoplasmic transport","mRNA surveillance pathway","Spliceosome","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
RBM8A	[]	8	["Nucleocytoplasmic transport","mRNA surveillance pathway","Spliceosome","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
RNPS1	[]	7	["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
CASC3	[]	7	["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
UPF3B	[]	7	["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]

MAGOHB (mago homolog B, exon junction complex subunit)

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