Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4116
Gene name	Mago homolog, exon junction complex subunit
Gene symbol	MAGOH
Synonyms (NCBI Gene)	MAGOH1MAGOHA
Chromosome	1
Chromosome location	1p32.3
Summary	Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the ger

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miRTarBase ID	miRNA	Experiments	Reference
MIRT040138	hsa-miR-615-3p	CLASH	23622248
MIRT1126067	hsa-miR-146b-3p	CLIP-seq
MIRT1126068	hsa-miR-200b	CLIP-seq
MIRT1126069	hsa-miR-200c	CLIP-seq
MIRT1126070	hsa-miR-3173-5p	CLIP-seq
MIRT1126071	hsa-miR-4282	CLIP-seq
MIRT1126072	hsa-miR-429	CLIP-seq
MIRT1126073	hsa-miR-4731-3p	CLIP-seq
MIRT1126074	hsa-miR-4789-5p	CLIP-seq
MIRT1126075	hsa-miR-4801	CLIP-seq
MIRT1126076	hsa-miR-874	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI	23917022
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP	16209946
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IMP	22203037
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	10662555, 12730685, 12781131, 14730019, 14973490, 16170325, 16209946, 16601204, 16797590, 16923391, 16931718, 18026120, 18066079, 19410547, 19417104, 19478851, 20479275, 21139563, 22365833, 22522823, 22720776, 23084401, 23435562, 23788676, 24981860, 25416956, 25616068, 26496610, 285
GO:0005634	Component	Nucleus	IDA	22720776
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21289489
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	NAS	21289489
GO:0006397	Process	MRNA processing	IEA
GO:0006406	Process	MRNA export from nucleus	NAS	11532962
GO:0006417	Process	Regulation of translation	IEA
GO:0008380	Process	RNA splicing	IBA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0035145	Component	Exon-exon junction complex	IBA
GO:0035145	Component	Exon-exon junction complex	IDA	16601204, 18026120, 19410547, 23917022
GO:0035145	Component	Exon-exon junction complex	IEA
GO:0035145	Component	Exon-exon junction complex	IPI	16931718
GO:0050684	Process	Regulation of mRNA processing	IDA	23115303
GO:0051028	Process	MRNA transport	IEA
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:1990501	Component	Exon-exon junction subcomplex mago-y14	IEA
GO:1990501	Component	Exon-exon junction subcomplex mago-y14	IPI	12781131
GO:2000622	Process	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA	19478851

MIM	HGNC	e!Ensembl
602603	6815	ENSG00000162385

P61326

Protein name

Protein mago nashi homolog

Protein function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638). Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway (PubMed:23917022). The EJC

PDB

1P27 , 2HYI , 2J0Q , 2J0S , 2XB2 , 3EX7 , 7A5P , 7W59 , 7W5A , 7W5B , 7ZNJ , 8C6J , 8I0W , 9FMD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02792	Mago_nashi	5 → 146	Mago nashi protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEEL
KRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLR
VFYYLVQDLKCLVFSLIGLHFKIKPI

Sequence length

146

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Nucleocytoplasmic transport	Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA surveillance pathway	mRNA Splicing - Major Pathway
Spliceosome	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination
	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
MAGOHB	[]	8	["Nucleocytoplasmic transport","mRNA surveillance pathway","Spliceosome","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
RBM8A	[]	8	["Nucleocytoplasmic transport","mRNA surveillance pathway","Spliceosome","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
RNPS1	[]	7	["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
CASC3	[]	7	["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]
UPF3B	[]	7	["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]	[]

MAGOH (mago homolog, exon junction complex subunit)

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