The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts w
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic str
["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["Nucleocytoplasmic transport","mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
0
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Diseases Linked via Similar GenesDiseases curated for genes most similar to CASC3 (see Related Genes above), that are NOT already directly curated for CASC3 itself -- a lead worth checking, not a confirmed association.