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Gene Gene information from NCBI Gene database.
Entrez ID 22794
Gene name CASC3 exon junction complex subunit
Gene symbol CASC3
Synonyms (NCBI Gene)
BTZMLN51
Chromosome 17
Chromosome location 17q21.1
Summary The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts w
miRNA miRNA information provided by mirtarbase database.
418 Show/Hide all (418)
miRTarBase ID miRNA Experiments Reference
MIRT004991 hsa-miR-125b-5p Microarray 17891175
MIRT021901 hsa-miR-128-3p Microarray 17612493
MIRT047186 hsa-miR-182-5p CLASH 23622248
MIRT046633 hsa-miR-222-3p CLASH 23622248
MIRT004991 hsa-miR-125b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37 Show/Hide all (37)
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
GO:0000398 Process MRNA splicing, via spliceosome IDA 29301961
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606504 17040 ENSG00000108349
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15234
Protein name Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
Protein function Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic str
PDB 2HYI , 2J0Q , 2J0S , 2J0U , 2XB2 , 3EX7 , 5XJC , 5YZG , 6ICZ , 7W59 , 7W5A , 7W5B , 8I0W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09405 Btz 137 → 249 CASC3/Barentsz eIF4AIII binding Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers. {ECO:0000269|PubMed:12080473}.
Sequence
MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALH
LRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEAN
DAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPA
YIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALY
GYDIRSAHN
PDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRN
AAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVR
DPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKL
AEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQ
PSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHI
SIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLY
PPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQV
YGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS
Sequence length 703
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Nucleocytoplasmic transport Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA surveillance pathway mRNA Splicing - Major Pathway
  mRNA 3'-end processing
  RNA Polymerase II Transcription Termination
  Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)