MRI1 (methylthioribose-1-phosphate isomerase 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 84245 |
| Gene name | Methylthioribose-1-phosphate isomerase 1 |
| Gene symbol | MRI1 |
| Synonyms (NCBI Gene) |
M1PiMRDIMTNAYpr118w
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| Chromosome | 19 |
| Chromosome location | 19p13.13 |
| Summary | This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein |
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SNPs
SNP information provided by dbSNP.
1
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miRNA
miRNA information provided by mirtarbase database.
643
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9BV20 | ||||||||||
| Protein name | Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) | ||||||||||
| Protein function | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK ty | ||||||||||
| PDB | 4LDQ , 4LDR | ||||||||||
| Family and domains |
Pfam
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| Sequence | |||||||||||
| Sequence length | 369 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with MRI1 across shared curated disease and pathway associations.
3
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to MRI1 (see Related Genes above), that are NOT already directly curated for MRI1 itself -- a lead worth checking, not a confirmed association.
5
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