ENOPH1 (enolase-phosphatase 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 58478
• Gene name: Enolase-phosphatase 1
• Gene symbol: ENOPH1
• Synonyms (NCBI Gene): E1, MASA, MST145, mtnC
• Chromosome: 4
• Chromosome location: 4q21.22

miRNA Show/Hide all (265)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019743	hsa-miR-375	Microarray	20215506
MIRT049352	hsa-miR-92a-3p	CLASH	23622248
MIRT042153	hsa-miR-484	CLASH	23622248
MIRT963647	hsa-miR-1229	CLIP-seq
MIRT963648	hsa-miR-124	CLIP-seq
MIRT963649	hsa-miR-1244	CLIP-seq
MIRT963650	hsa-miR-1252	CLIP-seq
MIRT963651	hsa-miR-1269	CLIP-seq
MIRT963652	hsa-miR-1269b	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT963654	hsa-miR-1288	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT963656	hsa-miR-148a	CLIP-seq
MIRT963657	hsa-miR-148b	CLIP-seq
MIRT963658	hsa-miR-152	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT963661	hsa-miR-2113	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT963664	hsa-miR-298	CLIP-seq
MIRT963665	hsa-miR-3117-5p	CLIP-seq
MIRT963666	hsa-miR-3121-3p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT963669	hsa-miR-3161	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT963671	hsa-miR-3173-3p	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT963675	hsa-miR-331-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963677	hsa-miR-342-3p	CLIP-seq
MIRT963678	hsa-miR-3612	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT963681	hsa-miR-3714	CLIP-seq
MIRT963682	hsa-miR-371-5p	CLIP-seq
MIRT963683	hsa-miR-371b-5p	CLIP-seq
MIRT963684	hsa-miR-3908	CLIP-seq
MIRT963685	hsa-miR-3910	CLIP-seq
MIRT963686	hsa-miR-3913-3p	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT963689	hsa-miR-3942-5p	CLIP-seq
MIRT963690	hsa-miR-409-3p	CLIP-seq
MIRT963691	hsa-miR-410	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT963695	hsa-miR-4305	CLIP-seq
MIRT963696	hsa-miR-4420	CLIP-seq
MIRT963697	hsa-miR-4422	CLIP-seq
MIRT963698	hsa-miR-4428	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT963701	hsa-miR-4490	CLIP-seq
MIRT963702	hsa-miR-4515	CLIP-seq
MIRT963703	hsa-miR-4639-5p	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT963706	hsa-miR-4678	CLIP-seq
MIRT963707	hsa-miR-4695-5p	CLIP-seq
MIRT963708	hsa-miR-4703-5p	CLIP-seq
MIRT963709	hsa-miR-4740-5p	CLIP-seq
MIRT963710	hsa-miR-4760-5p	CLIP-seq
MIRT963711	hsa-miR-4766-3p	CLIP-seq
MIRT963712	hsa-miR-4777-3p	CLIP-seq
MIRT963713	hsa-miR-489	CLIP-seq
MIRT963714	hsa-miR-506	CLIP-seq
MIRT963715	hsa-miR-5096	CLIP-seq
MIRT963716	hsa-miR-513c	CLIP-seq
MIRT963717	hsa-miR-514b-5p	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT963720	hsa-miR-548a-3p	CLIP-seq
MIRT963721	hsa-miR-548an	CLIP-seq
MIRT963722	hsa-miR-548e	CLIP-seq
MIRT963723	hsa-miR-548f	CLIP-seq
MIRT963724	hsa-miR-548g	CLIP-seq
MIRT963725	hsa-miR-562	CLIP-seq
MIRT963726	hsa-miR-576-3p	CLIP-seq
MIRT963727	hsa-miR-599	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT963729	hsa-miR-630	CLIP-seq
MIRT963730	hsa-miR-650	CLIP-seq
MIRT1985656	hsa-miR-1207-5p	CLIP-seq
MIRT963647	hsa-miR-1229	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT1985657	hsa-miR-153	CLIP-seq
MIRT1985658	hsa-miR-2110	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT963665	hsa-miR-3117-5p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT1985659	hsa-miR-3159	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT1985660	hsa-miR-3177-5p	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT1985661	hsa-miR-326	CLIP-seq
MIRT1985662	hsa-miR-330-5p	CLIP-seq
MIRT963677	hsa-miR-342-3p	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT1985663	hsa-miR-4271	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT963695	hsa-miR-4305	CLIP-seq
MIRT1985664	hsa-miR-4307	CLIP-seq
MIRT963696	hsa-miR-4420	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT1985665	hsa-miR-448	CLIP-seq
MIRT1985666	hsa-miR-4643	CLIP-seq
MIRT1985667	hsa-miR-4659a-3p	CLIP-seq
MIRT1985668	hsa-miR-4659b-3p	CLIP-seq
MIRT1985669	hsa-miR-466	CLIP-seq
MIRT1985670	hsa-miR-4667-5p	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT963706	hsa-miR-4678	CLIP-seq
MIRT1985671	hsa-miR-4700-5p	CLIP-seq
MIRT1985672	hsa-miR-4725-3p	CLIP-seq
MIRT1985673	hsa-miR-4736	CLIP-seq
MIRT963710	hsa-miR-4760-5p	CLIP-seq
MIRT1985674	hsa-miR-4763-3p	CLIP-seq
MIRT1985675	hsa-miR-4789-3p	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT1985676	hsa-miR-549	CLIP-seq
MIRT963726	hsa-miR-576-3p	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT1985677	hsa-miR-637	CLIP-seq
MIRT2220101	hsa-miR-1227	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT1985658	hsa-miR-2110	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT2220102	hsa-miR-3064-3p	CLIP-seq
MIRT963665	hsa-miR-3117-5p	CLIP-seq
MIRT963666	hsa-miR-3121-3p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT2220103	hsa-miR-3141	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT1985661	hsa-miR-326	CLIP-seq
MIRT1985662	hsa-miR-330-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963691	hsa-miR-410	CLIP-seq
MIRT1985663	hsa-miR-4271	CLIP-seq
MIRT2220104	hsa-miR-4282	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963695	hsa-miR-4305	CLIP-seq
MIRT2220105	hsa-miR-4329	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT1985670	hsa-miR-4667-5p	CLIP-seq
MIRT1985671	hsa-miR-4700-5p	CLIP-seq
MIRT1985672	hsa-miR-4725-3p	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT1985676	hsa-miR-549	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT1985677	hsa-miR-637	CLIP-seq
MIRT963647	hsa-miR-1229	CLIP-seq
MIRT963650	hsa-miR-1252	CLIP-seq
MIRT963651	hsa-miR-1269	CLIP-seq
MIRT963652	hsa-miR-1269b	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT963654	hsa-miR-1288	CLIP-seq
MIRT963655	hsa-miR-1296	CLIP-seq
MIRT1985657	hsa-miR-153	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963663	hsa-miR-2909	CLIP-seq
MIRT963664	hsa-miR-298	CLIP-seq
MIRT2523950	hsa-miR-3124-3p	CLIP-seq
MIRT963667	hsa-miR-3125	CLIP-seq
MIRT963668	hsa-miR-3158-3p	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT963671	hsa-miR-3173-3p	CLIP-seq
MIRT2523951	hsa-miR-3174	CLIP-seq
MIRT1985660	hsa-miR-3177-5p	CLIP-seq
MIRT963672	hsa-miR-3180-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963677	hsa-miR-342-3p	CLIP-seq
MIRT963678	hsa-miR-3612	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT2523952	hsa-miR-374a	CLIP-seq
MIRT2523953	hsa-miR-374b	CLIP-seq
MIRT963686	hsa-miR-3913-3p	CLIP-seq
MIRT963687	hsa-miR-3916	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT963690	hsa-miR-409-3p	CLIP-seq
MIRT963691	hsa-miR-410	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT2220104	hsa-miR-4282	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT1985664	hsa-miR-4307	CLIP-seq
MIRT963698	hsa-miR-4428	CLIP-seq
MIRT2523954	hsa-miR-4432	CLIP-seq
MIRT963699	hsa-miR-4437	CLIP-seq
MIRT963700	hsa-miR-4446-3p	CLIP-seq
MIRT1985665	hsa-miR-448	CLIP-seq
MIRT963702	hsa-miR-4515	CLIP-seq
MIRT2523955	hsa-miR-4517	CLIP-seq
MIRT1985666	hsa-miR-4643	CLIP-seq
MIRT1985669	hsa-miR-466	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT963707	hsa-miR-4695-5p	CLIP-seq
MIRT963709	hsa-miR-4740-5p	CLIP-seq
MIRT1985675	hsa-miR-4789-3p	CLIP-seq
MIRT963713	hsa-miR-489	CLIP-seq
MIRT963718	hsa-miR-520a-5p	CLIP-seq
MIRT963719	hsa-miR-525-5p	CLIP-seq
MIRT963728	hsa-miR-600	CLIP-seq
MIRT963730	hsa-miR-650	CLIP-seq
MIRT963650	hsa-miR-1252	CLIP-seq
MIRT963653	hsa-miR-127-5p	CLIP-seq
MIRT1985657	hsa-miR-153	CLIP-seq
MIRT963659	hsa-miR-200b	CLIP-seq
MIRT963660	hsa-miR-200c	CLIP-seq
MIRT963662	hsa-miR-2116	CLIP-seq
MIRT963664	hsa-miR-298	CLIP-seq
MIRT2523950	hsa-miR-3124-3p	CLIP-seq
MIRT963670	hsa-miR-3163	CLIP-seq
MIRT2523951	hsa-miR-3174	CLIP-seq
MIRT1985660	hsa-miR-3177-5p	CLIP-seq
MIRT963673	hsa-miR-3200-3p	CLIP-seq
MIRT963674	hsa-miR-3200-5p	CLIP-seq
MIRT963676	hsa-miR-340	CLIP-seq
MIRT963679	hsa-miR-3672	CLIP-seq
MIRT963680	hsa-miR-3688-3p	CLIP-seq
MIRT963686	hsa-miR-3913-3p	CLIP-seq
MIRT963688	hsa-miR-3924	CLIP-seq
MIRT963692	hsa-miR-4273	CLIP-seq
MIRT2220104	hsa-miR-4282	CLIP-seq
MIRT963693	hsa-miR-429	CLIP-seq
MIRT963694	hsa-miR-4303	CLIP-seq
MIRT1985664	hsa-miR-4307	CLIP-seq
MIRT2523954	hsa-miR-4432	CLIP-seq
MIRT1985665	hsa-miR-448	CLIP-seq
MIRT1985666	hsa-miR-4643	CLIP-seq
MIRT1985669	hsa-miR-466	CLIP-seq
MIRT963704	hsa-miR-4670-3p	CLIP-seq
MIRT963705	hsa-miR-4677-5p	CLIP-seq
MIRT1985675	hsa-miR-4789-3p	CLIP-seq
MIRT963713	hsa-miR-489	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008652	Process	Amino acid biosynthetic process	IEA
GO:0009086	Process	Methionine biosynthetic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IBA
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IDA	15843022
GO:0019509	Process	L-methionine salvage from methylthioadenosine	IEA
GO:0043874	Function	Acireductone synthase activity	IBA
GO:0043874	Function	Acireductone synthase activity	IDA	15843022
GO:0043874	Function	Acireductone synthase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9UHY7
• Protein name: Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)
• Protein function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the aci
• PDB: 1YNS , 1ZS9
• Sequence:

  MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLR
  KQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRA
  AFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHF
  DTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTD
  DEKTYYSLITSFSELYLPSST

• Sequence length: 261

Pathways

KEGG Pathway	Reactome Pathway
Cysteine and methionine metabolism	Methionine salvage pathway
Metabolic pathways

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	40708016	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	40708016	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	BEFREE	16088863, 8826452		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30066900		★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	BEFREE	15662685, 16088863, 8636066		★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	BEFREE	15662685		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	8782167, 8826452, 9744477		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31281503		★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	30066900		★☆☆☆☆ Found in Text Mining only
MASA SYNDROME (disorder)	MASA syndrome	BEFREE	15662685, 8809896, 8826452		★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	8782167, 8826452, 9744477		★☆☆☆☆ Found in Text Mining only
Thumb in palm deformity	Adducted thumbs syndrome	BEFREE	16088863, 7762552, 8636066		★☆☆☆☆ Found in Text Mining only
X-linked hydrocephalus syndrome	Hydrocephalus Syndrome, X-Linked	BEFREE	8636066, 8826452, 9521424		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ADI1 2 shared pathwaysCysteine and methionine metabolism, Methionine salvage pathway Related via 2 shared pathways including Cysteine and methionine metabolism, Methionine salvage pathway. MRI1 2 shared pathwaysCysteine and methionine metabolism, Methionine salvage pathway Related via 2 shared pathways including Cysteine and methionine metabolism, Methionine salvage pathway. MTAP 2 shared pathwaysCysteine and methionine metabolism, Methionine salvage pathway Related via 2 shared pathways including Cysteine and methionine metabolism, Methionine salvage pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ADI1	0	[]	2	["Cysteine and methionine metabolism","Methionine salvage pathway"]	0	[]
MRI1	0	[]	2	["Cysteine and methionine metabolism","Methionine salvage pathway"]	0	[]
MTAP	0	[]	2	["Cysteine and methionine metabolism","Methionine salvage pathway"]	0	[]

Diseases Linked via Similar Genes

Prostatic neoplasms Linked via 2 of 3 related genesADI1, MTAP Basal cell carcinoma Linked via 1 of 3 related genesMTAP Biliary tract cancer Linked via 1 of 3 related genesMTAP Breast cancer Linked via 1 of 3 related genesMTAP Cancer Linked via 1 of 3 related genesMTAP

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Prostatic neoplasms	2	["ADI1","MTAP"]
Basal cell carcinoma	1	["MTAP"]
Biliary tract cancer	1	["MTAP"]
Breast cancer	1	["MTAP"]
Cancer	1	["MTAP"]