LIPF (lipase F, gastric type)

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Gene Gene information from NCBI Gene database.
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Entrez ID 8513
Gene name Lipase F, gastric type
Gene symbol LIPF
Synonyms (NCBI Gene)
GLHGLHLAL
Chromosome 10
Chromosome location 10q23.31
Summary This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
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GO ID Ontology Definition Evidence Reference
GO:0004806 Function Triacylglycerol lipase activity IBA
GO:0004806 Function Triacylglycerol lipase activity IDA 2243091, 10358049
GO:0004806 Function Triacylglycerol lipase activity IEA
GO:0004806 Function Triacylglycerol lipase activity TAS 3304425
GO:0005515 Function Protein binding IPI 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
601980 6622 ENSG00000182333
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07098
Protein name Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3)
Protein function Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:10358049, PubMed:2243091). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). {
PDB 1HLG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00561 Abhydrolase_1 78 → 378 alpha/beta hydrolase fold Domain
Sequence
Sequence length 398
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Glycerolipid metabolism Digestion of dietary lipid
Metabolic pathways  
Fat digestion and absorption  
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PNLIPRP1 3 shared pathwaysGlycerolipid metabolism, Fat digestion and absorption, Digestion of dietary lipid Related via 3 shared pathways including Glycerolipid metabolism, Fat digestion and absorption. PNLIPRP2 3 shared pathwaysGlycerolipid metabolism, Fat digestion and absorption, Digestion of dietary lipid Related via 3 shared pathways including Glycerolipid metabolism, Fat digestion and absorption. PNLIPRP3 2 shared pathwaysGlycerolipid metabolism, Digestion of dietary lipid Related via 2 shared pathways including Glycerolipid metabolism, Digestion of dietary lipid. MOGAT3 2 shared pathwaysGlycerolipid metabolism, Fat digestion and absorption Related via 2 shared pathways including Glycerolipid metabolism, Fat digestion and absorption. PNLIP 3 shared pathwaysGlycerolipid metabolism, Fat digestion and absorption, Digestion of dietary lipid Related via 3 shared pathways including Glycerolipid metabolism, Fat digestion and absorption.
Alzheimer disease Linked via 2 of 5 related genesPNLIPRP1, PNLIPRP2 Glaucoma Linked via 1 of 5 related genesPNLIPRP1 Oligodendroglioma Linked via 1 of 5 related genesPNLIPRP1 Coronary artery disease Linked via 1 of 5 related genesPNLIPRP2 Pancreatic lipase deficiency Linked via 1 of 5 related genesPNLIP