KRT84 (keratin 84)

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Gene Gene information from NCBI Gene database.
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Entrez ID 3890
Gene name Keratin 84
Gene symbol KRT84
Synonyms (NCBI Gene)
HB4KRTHB4
Chromosome 12
Chromosome location 12q13.13
Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome
miRNA miRNA information provided by mirtarbase database.
4
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miRTarBase ID miRNA Experiments Reference
MIRT2027684 hsa-miR-4659a-3p CLIP-seq
MIRT2027685 hsa-miR-4659b-3p CLIP-seq
MIRT2027686 hsa-miR-942 CLIP-seq
MIRT2259015 hsa-miR-4487 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
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GO ID Ontology Definition Evidence Reference
GO:0001942 Process Hair follicle development NAS 10692104
GO:0005200 Function Structural constituent of cytoskeleton NAS 10692104
GO:0005829 Component Cytosol IEA
GO:0005829 Component Cytosol TAS
GO:0005882 Component Intermediate filament IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
602766 6461 ENSG00000161849
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NSB2
Protein name Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00038 Filament 164 → 475 Intermediate filament protein Coiled-coil
PF16208 Keratin_2_head 16 → 161 Keratin type II head Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the hair follicles. {ECO:0000269|PubMed:10692104}.
Sequence
Sequence length 600
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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Reactome Pathway
Keratinization
Formation of the cornified envelope
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PKP3 2 shared pathwaysKeratinization, Formation of the cornified envelope Related via 2 shared pathways including Keratinization, Formation of the cornified envelope. KRT71 2 shared pathwaysKeratinization, Formation of the cornified envelope Related via 2 shared pathways including Keratinization, Formation of the cornified envelope. KRT74 2 shared pathwaysKeratinization, Formation of the cornified envelope Related via 2 shared pathways including Keratinization, Formation of the cornified envelope. KRT72 2 shared pathwaysKeratinization, Formation of the cornified envelope Related via 2 shared pathways including Keratinization, Formation of the cornified envelope. KRT80 2 shared pathwaysKeratinization, Formation of the cornified envelope Related via 2 shared pathways including Keratinization, Formation of the cornified envelope.
Androgenetic alopecia Linked via 2 of 5 related genesKRT71, KRT74 Hypotrichosis Linked via 2 of 5 related genesKRT71, KRT74 Woolly hair Linked via 2 of 5 related genesKRT71, KRT74 Anorectal malformation Linked via 1 of 5 related genesPKP3 Prostatic neoplasms Linked via 1 of 5 related genesPKP3