Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	374454
Gene name	Keratin 77
Gene symbol	KRT77
Synonyms (NCBI Gene)	K1BKRT1B
Chromosome	12
Chromosome location	12q13.13
Summary	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat

59 Show/Hide all (59)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028485	hsa-miR-30a-5p	Proteomics	18668040
MIRT1101498	hsa-miR-1193	CLIP-seq
MIRT1101499	hsa-miR-147	CLIP-seq
MIRT1101500	hsa-miR-219-1-3p	CLIP-seq
MIRT1101501	hsa-miR-3175	CLIP-seq
MIRT1101502	hsa-miR-3667-5p	CLIP-seq
MIRT1101503	hsa-miR-3688-5p	CLIP-seq
MIRT1101504	hsa-miR-3691-3p	CLIP-seq
MIRT1101505	hsa-miR-378g	CLIP-seq
MIRT1101506	hsa-miR-3911	CLIP-seq
MIRT1101507	hsa-miR-3941	CLIP-seq
MIRT1101508	hsa-miR-4487	CLIP-seq
MIRT1101509	hsa-miR-466	CLIP-seq
MIRT1101510	hsa-miR-4672	CLIP-seq
MIRT1101511	hsa-miR-571	CLIP-seq
MIRT1101512	hsa-miR-619	CLIP-seq
MIRT1101513	hsa-miR-644	CLIP-seq
MIRT2027590	hsa-miR-1827	CLIP-seq
MIRT2027591	hsa-miR-214	CLIP-seq
MIRT2027592	hsa-miR-2355-5p	CLIP-seq
MIRT2027593	hsa-miR-2467-3p	CLIP-seq
MIRT2027594	hsa-miR-3125	CLIP-seq
MIRT2027595	hsa-miR-3612	CLIP-seq
MIRT2027596	hsa-miR-3619-5p	CLIP-seq
MIRT2027597	hsa-miR-3916	CLIP-seq
MIRT2027598	hsa-miR-4281	CLIP-seq
MIRT2027599	hsa-miR-432	CLIP-seq
MIRT2027600	hsa-miR-4436b-3p	CLIP-seq
MIRT2027601	hsa-miR-4443	CLIP-seq
MIRT2027602	hsa-miR-4530	CLIP-seq
MIRT2027603	hsa-miR-650	CLIP-seq
MIRT2027604	hsa-miR-761	CLIP-seq
MIRT2027605	hsa-miR-890	CLIP-seq
MIRT2258946	hsa-miR-1200	CLIP-seq
MIRT2258947	hsa-miR-2115	CLIP-seq
MIRT2258948	hsa-miR-3140-5p	CLIP-seq
MIRT2258949	hsa-miR-3153	CLIP-seq
MIRT1101501	hsa-miR-3175	CLIP-seq
MIRT2258950	hsa-miR-3192	CLIP-seq
MIRT2258951	hsa-miR-3662	CLIP-seq
MIRT2258952	hsa-miR-376a	CLIP-seq
MIRT2258953	hsa-miR-376b	CLIP-seq
MIRT2258954	hsa-miR-4290	CLIP-seq
MIRT2258955	hsa-miR-4314	CLIP-seq
MIRT2027602	hsa-miR-4530	CLIP-seq
MIRT2258956	hsa-miR-4646-5p	CLIP-seq
MIRT2258957	hsa-miR-4668-5p	CLIP-seq
MIRT2258958	hsa-miR-4761-3p	CLIP-seq
MIRT2258959	hsa-miR-493	CLIP-seq
MIRT2258960	hsa-miR-494	CLIP-seq
MIRT2258961	hsa-miR-508-5p	CLIP-seq
MIRT2258962	hsa-miR-516a-3p	CLIP-seq
MIRT2258963	hsa-miR-873	CLIP-seq
MIRT2559533	hsa-miR-200b	CLIP-seq
MIRT2559534	hsa-miR-200c	CLIP-seq
MIRT2559535	hsa-miR-22	CLIP-seq
MIRT2559536	hsa-miR-374c	CLIP-seq
MIRT2559537	hsa-miR-429	CLIP-seq
MIRT2559538	hsa-miR-655	CLIP-seq

12 Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IDA	16117782
GO:0005882	Component	Intermediate filament	IEA
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0031424	Process	Keratinization	IBA
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IEA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
611158	20411	ENSG00000189182

Q7Z794

Protein name

Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00038	Filament	163 → 476	Intermediate filament protein	Coiled-coil
PF16208	Keratin_2_head	4 → 160	Keratin type II head	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed exclusively in skin. {ECO:0000269|PubMed:15737194}.

Sequence

MSHQFSSQSAFSSMSRRVYSTSSSAGSGGGSPAVGSVCYARGRCGGGGYGIHGRGFGSRS
LYNLGGSRSISINLMGRSTSGFCQGGGVGGFGGGRGFGVGSTGAGGFGGGGFGGAGFGTS
NFGLGGFGPYCPPGGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFID
KVRFLEQQNQVLQTKWELLQQVNTSTGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEV
RSMQDVVEDYKSKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLK
YLFLTELSQVQTHISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTK
YQELQITAGRHGDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQA
LQDAWQKLQDLEEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGE
LQSHVSISVQNSQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRSGGGYGS
GCGGGGGSYGGSGRSGRGSSRVQIIQTSTNTSHRRILE

Sequence length

578

Interactions

View interactions

Reactome Pathway
Keratinization
Formation of the cornified envelope

KRT77 (keratin 77)

Bookmark This Gene