Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 23633
Gene name Karyopherin subunit alpha 6
Gene symbol KPNA6
Synonyms (NCBI Gene)
IPOA7
Chromosome 1
Chromosome location 1p35.2
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a het
miRNA miRNA information provided by mirtarbase database.
2163 Show/Hide all (2163)
miRTarBase ID miRNA Experiments Reference
MIRT027429 hsa-miR-98-5p Microarray 19088304
MIRT030446 hsa-miR-24-3p Microarray 19748357
MIRT052621 hsa-let-7a-5p CLASH 23622248
MIRT052349 hsa-let-7b-5p CLASH 23622248
MIRT049058 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29 Show/Hide all (29)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 10523667, 16713569, 20064372, 22810585, 25158218, 25416956, 25599645, 25910212, 26420826, 26496610, 28169297, 32296183, 33961781, 34950606, 35271311
GO:0005634 Component Nucleus IBA
GO:0005654 Component Nucleoplasm IBA
GO:0005654 Component Nucleoplasm NAS 20818336
GO:0005654 Component Nucleoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610563 6399 ENSG00000025800
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60684
Protein name Importin subunit alpha-7 (Karyopherin subunit alpha-6)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore
PDB 4UAD , 7RHT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00514 Arm 156 → 196 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 325 → 365 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 198 → 239 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 367 → 407 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 112 → 154 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 283 → 323 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 410 → 450 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 241 → 281 Armadillo/beta-catenin-like repeat Repeat
PF01749 IBB 13 → 102 Importin beta binding domain Family
PF16186 Arm_3 464 → 514 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10523667}.
Sequence
Sequence length 536
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Nucleocytoplasmic transport
Influenza A
Chemical carcinogenesis - receptor activation