Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the f
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
0
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Diseases Linked via Similar GenesDiseases curated for genes most similar to H3C2 (see Related Genes above), that are NOT already directly curated for H3C2 itself -- a lead worth checking, not a confirmed association.