GOLIM4 (golgi integral membrane protein 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27333
• Gene name: Golgi integral membrane protein 4
• Gene symbol: GOLIM4
• Synonyms (NCBI Gene): GIMPC, GOLPH4, GPP130, P138
• Chromosome: 3
• Chromosome location: 3q26.2
• Summary: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reti

miRNA Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049004	hsa-miR-92a-3p	CLASH	23622248
MIRT048034	hsa-miR-148a-3p	CLASH	23622248
MIRT045671	hsa-miR-149-5p	CLASH	23622248
MIRT643154	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT643153	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT643152	hsa-miR-302a-5p	HITS-CLIP	23824327
MIRT643151	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT643150	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT643149	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT548052	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT548051	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT548050	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT548049	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT548048	hsa-miR-646	PAR-CLIP	21572407
MIRT548047	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT548046	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT548044	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT548045	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT548043	hsa-miR-940	PAR-CLIP	21572407
MIRT548042	hsa-miR-2682-5p	PAR-CLIP	21572407
MIRT548041	hsa-miR-34b-5p	PAR-CLIP	21572407
MIRT548040	hsa-miR-449c-5p	PAR-CLIP	21572407
MIRT548039	hsa-miR-5000-5p	PAR-CLIP	21572407
MIRT548038	hsa-miR-936	PAR-CLIP	21572407
MIRT548036	hsa-miR-4468	PAR-CLIP	21572407
MIRT548037	hsa-miR-6806-5p	PAR-CLIP	21572407
MIRT548034	hsa-miR-8055	PAR-CLIP	21572407
MIRT548035	hsa-miR-105-3p	PAR-CLIP	21572407
MIRT548052	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT548051	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT548050	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT548049	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT548048	hsa-miR-646	PAR-CLIP	21572407
MIRT548047	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT548046	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT548044	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT548045	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT548043	hsa-miR-940	PAR-CLIP	21572407
MIRT548042	hsa-miR-2682-5p	PAR-CLIP	21572407
MIRT548041	hsa-miR-34b-5p	PAR-CLIP	21572407
MIRT548040	hsa-miR-449c-5p	PAR-CLIP	21572407
MIRT548039	hsa-miR-5000-5p	PAR-CLIP	21572407
MIRT548038	hsa-miR-936	PAR-CLIP	21572407
MIRT548036	hsa-miR-4468	PAR-CLIP	21572407
MIRT548037	hsa-miR-6806-5p	PAR-CLIP	21572407
MIRT526478	hsa-miR-222-5p	PAR-CLIP	21572407
MIRT548034	hsa-miR-8055	PAR-CLIP	21572407
MIRT548035	hsa-miR-105-3p	PAR-CLIP	21572407
MIRT548032	hsa-miR-4282	PAR-CLIP	21572407
MIRT548033	hsa-miR-3163	PAR-CLIP	21572407
MIRT548031	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT548030	hsa-miR-3659	PAR-CLIP	21572407
MIRT548029	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT548028	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT548027	hsa-miR-4477a	PAR-CLIP	21572407
MIRT548025	hsa-miR-4658	PAR-CLIP	21572407
MIRT548026	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT548024	hsa-miR-487a-5p	PAR-CLIP	21572407
MIRT548023	hsa-miR-487b-5p	PAR-CLIP	21572407
MIRT526480	hsa-miR-16-1-3p	PAR-CLIP	22012620
MIRT526479	hsa-miR-556-3p	PAR-CLIP	22012620
MIRT526478	hsa-miR-222-5p	PAR-CLIP	22012620
MIRT526477	hsa-miR-30a-3p	PAR-CLIP	22012620
MIRT526476	hsa-miR-30d-3p	PAR-CLIP	22012620
MIRT526475	hsa-miR-30e-3p	PAR-CLIP	22012620
MIRT643154	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT643153	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT643152	hsa-miR-302a-5p	HITS-CLIP	23824327
MIRT643151	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT643150	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT643149	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT548052	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT548051	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT548050	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT548049	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT548048	hsa-miR-646	PAR-CLIP	21572407
MIRT548047	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT548046	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT548044	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT548045	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT548043	hsa-miR-940	PAR-CLIP	21572407
MIRT548042	hsa-miR-2682-5p	PAR-CLIP	21572407
MIRT548041	hsa-miR-34b-5p	PAR-CLIP	21572407
MIRT548040	hsa-miR-449c-5p	PAR-CLIP	21572407
MIRT548039	hsa-miR-5000-5p	PAR-CLIP	21572407
MIRT548038	hsa-miR-936	PAR-CLIP	21572407
MIRT548036	hsa-miR-4468	PAR-CLIP	21572407
MIRT548037	hsa-miR-6806-5p	PAR-CLIP	21572407
MIRT548034	hsa-miR-8055	PAR-CLIP	21572407
MIRT548035	hsa-miR-105-3p	PAR-CLIP	21572407
MIRT548052	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT548051	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT548050	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT548049	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT548048	hsa-miR-646	PAR-CLIP	21572407
MIRT548047	hsa-miR-1910-3p	PAR-CLIP	21572407
MIRT548046	hsa-miR-6511a-5p	PAR-CLIP	21572407
MIRT548044	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT548045	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT548043	hsa-miR-940	PAR-CLIP	21572407
MIRT548042	hsa-miR-2682-5p	PAR-CLIP	21572407
MIRT548041	hsa-miR-34b-5p	PAR-CLIP	21572407
MIRT548040	hsa-miR-449c-5p	PAR-CLIP	21572407
MIRT548039	hsa-miR-5000-5p	PAR-CLIP	21572407
MIRT548038	hsa-miR-936	PAR-CLIP	21572407
MIRT548036	hsa-miR-4468	PAR-CLIP	21572407
MIRT548037	hsa-miR-6806-5p	PAR-CLIP	21572407
MIRT526478	hsa-miR-222-5p	PAR-CLIP	21572407
MIRT548034	hsa-miR-8055	PAR-CLIP	21572407
MIRT548035	hsa-miR-105-3p	PAR-CLIP	21572407
MIRT548032	hsa-miR-4282	PAR-CLIP	21572407
MIRT548033	hsa-miR-3163	PAR-CLIP	21572407
MIRT548031	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT548030	hsa-miR-3659	PAR-CLIP	21572407
MIRT548029	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT548028	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT548027	hsa-miR-4477a	PAR-CLIP	21572407
MIRT548025	hsa-miR-4658	PAR-CLIP	21572407
MIRT548026	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT548024	hsa-miR-487a-5p	PAR-CLIP	21572407
MIRT548023	hsa-miR-487b-5p	PAR-CLIP	21572407
MIRT526480	hsa-miR-16-1-3p	PAR-CLIP	22012620
MIRT526479	hsa-miR-556-3p	PAR-CLIP	22012620
MIRT526478	hsa-miR-222-5p	PAR-CLIP	22012620
MIRT526477	hsa-miR-30a-3p	PAR-CLIP	22012620
MIRT526476	hsa-miR-30d-3p	PAR-CLIP	22012620
MIRT526475	hsa-miR-30e-3p	PAR-CLIP	22012620
MIRT1026917	hsa-miR-2682	CLIP-seq
MIRT1026918	hsa-miR-3684	CLIP-seq
MIRT1026919	hsa-miR-4305	CLIP-seq
MIRT1026920	hsa-miR-4307	CLIP-seq
MIRT1026921	hsa-miR-449c	CLIP-seq
MIRT2004556	hsa-miR-300	CLIP-seq
MIRT2004557	hsa-miR-381	CLIP-seq
MIRT2004558	hsa-miR-4666-3p	CLIP-seq
MIRT2004559	hsa-miR-494	CLIP-seq
MIRT2004560	hsa-miR-499-3p	CLIP-seq
MIRT2004561	hsa-miR-499a-3p	CLIP-seq
MIRT2004562	hsa-miR-556-5p	CLIP-seq
MIRT2237353	hsa-miR-2116	CLIP-seq
MIRT1026917	hsa-miR-2682	CLIP-seq
MIRT1026920	hsa-miR-4307	CLIP-seq
MIRT1026921	hsa-miR-449c	CLIP-seq
MIRT2237354	hsa-miR-450b-5p	CLIP-seq
MIRT2237355	hsa-miR-4677-5p	CLIP-seq
MIRT2237356	hsa-miR-4742-3p	CLIP-seq
MIRT2237357	hsa-miR-486-5p	CLIP-seq
MIRT2004560	hsa-miR-499-3p	CLIP-seq
MIRT2004561	hsa-miR-499a-3p	CLIP-seq
MIRT2237358	hsa-miR-507	CLIP-seq
MIRT2004562	hsa-miR-556-5p	CLIP-seq
MIRT2237359	hsa-miR-557	CLIP-seq
MIRT2237360	hsa-miR-605	CLIP-seq
MIRT2004556	hsa-miR-300	CLIP-seq
MIRT2004557	hsa-miR-381	CLIP-seq
MIRT2004558	hsa-miR-4666-3p	CLIP-seq
MIRT2004559	hsa-miR-494	CLIP-seq
MIRT2004560	hsa-miR-499-3p	CLIP-seq
MIRT2004561	hsa-miR-499a-3p	CLIP-seq
MIRT2004562	hsa-miR-556-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	9201717
GO:0005794	Component	Golgi apparatus	IEA
GO:0005796	Component	Golgi lumen	TAS	9201717
GO:0005801	Component	Cis-Golgi network	TAS	9201717
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	9201717
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9201717
GO:0030133	Component	Transport vesicle	TAS
GO:0030139	Component	Endocytic vesicle	TAS	9201717
GO:0032580	Component	Golgi cisterna membrane	IEA

Other IDs

• MIM: 606805
• HGNC: 15448
• e!Ensembl: ENSG00000173905

Protein

• UniProt ID: O00461
• Protein name: Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)
• Protein function: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
• Sequence:

  MGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQ
  LQVVYEHRSRLEKSLQKERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQM
  LKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKETVYNLRE
  ENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDT
  LNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAE
  DTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEE
  HDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQ
  VEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQ
  AHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEA
  DRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAG
  NPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGEEQEV
  RDDNRPKGREEHYEEEEEEEEDGAAVAEKSHRRAEM

• Sequence length: 696

Pathways

Reactome Pathway:

Intra-Golgi traffic

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (12)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BARRETT'S ESOPHAGUS	—	GWAS catalog	24121790	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	30487263	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIGESTIVE SYSTEM DISEASE	—	GWAS catalog	24121790	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPILEPSY	—	GWAS catalog	25087078	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL ADENOCARCINOMA	—	GWAS catalog	24121790	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENERALISED EPILEPSY	—	GWAS catalog	25087078	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	38965376	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARTIAL EPILEPSY	—	GWAS catalog	25087078	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROLIFERATIVE DIABETIC RETINOPATHY	—	GWAS catalog	30487263	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	38469033	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (14)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	29274321		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33722196	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	34180133	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	30068697		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	30068697	Inhibit	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	40649939	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	40649939	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	30068697		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	17854043		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34180133	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30068697		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	40649939	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	30068697	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PRSS55 3 shared diseasesBarrett esophagus, Esophageal adenocarcinoma, Psychiatric disorders 3 shared evidence sourcesGWAS catalog (Barrett esophagus), GWAS catalog (Esophageal adenocarcinoma), GWAS catalog (Psychiatric disorders) Related via 3 shared diseases including Barrett esophagus, Esophageal adenocarcinoma — evidence mostly GWAS catalog. OGA 3 shared diseasesPartial epilepsy, Epilepsy, Generalized epilepsy 3 shared evidence sourcesGWAS catalog (Epilepsy), GWAS catalog (Generalized epilepsy), GWAS catalog (Partial epilepsy) Related via 3 shared diseases including Partial epilepsy, Epilepsy — evidence mostly GWAS catalog. BARX1 3 shared diseasesBarrett esophagus, Digestive system disease, Esophageal adenocarcinoma 3 shared evidence sourcesGWAS catalog (Barrett esophagus), GWAS catalog (Digestive system disease), GWAS catalog (Esophageal adenocarcinoma) Related via 3 shared diseases including Barrett esophagus, Digestive system disease — evidence mostly GWAS catalog. CAMSAP2 3 shared diseasesPartial epilepsy, Epilepsy, Generalized epilepsy 3 shared evidence sourcesGWAS catalog (Epilepsy), GWAS catalog (Generalized epilepsy), GWAS catalog (Partial epilepsy) Related via 3 shared diseases including Partial epilepsy, Epilepsy — evidence mostly GWAS catalog. KHDRBS2 3 shared diseasesBarrett esophagus, Digestive system disease, Esophageal adenocarcinoma 3 shared evidence sourcesGWAS catalog (Barrett esophagus), GWAS catalog (Digestive system disease), GWAS catalog (Esophageal adenocarcinoma) Related via 3 shared diseases including Barrett esophagus, Digestive system disease — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PRSS55	3	["Barrett esophagus","Esophageal adenocarcinoma","Psychiatric disorders"]	0	[]	3	["GWAS catalog (Barrett esophagus)","GWAS catalog (Esophageal adenocarcinoma)","GWAS catalog (Psychiatric disorders)"]
OGA	3	["Partial epilepsy","Epilepsy","Generalized epilepsy"]	0	[]	3	["GWAS catalog (Epilepsy)","GWAS catalog (Generalized epilepsy)","GWAS catalog (Partial epilepsy)"]
BARX1	3	["Barrett esophagus","Digestive system disease","Esophageal adenocarcinoma"]	0	[]	3	["GWAS catalog (Barrett esophagus)","GWAS catalog (Digestive system disease)","GWAS catalog (Esophageal adenocarcinoma)"]
CAMSAP2	3	["Partial epilepsy","Epilepsy","Generalized epilepsy"]	0	[]	3	["GWAS catalog (Epilepsy)","GWAS catalog (Generalized epilepsy)","GWAS catalog (Partial epilepsy)"]
KHDRBS2	3	["Barrett esophagus","Digestive system disease","Esophageal adenocarcinoma"]	0	[]	3	["GWAS catalog (Barrett esophagus)","GWAS catalog (Digestive system disease)","GWAS catalog (Esophageal adenocarcinoma)"]

Diseases Linked via Similar Genes

Obesity Linked via 2 of 5 related genesPRSS55, KHDRBS2 Alzheimer disease Linked via 2 of 5 related genesOGA, KHDRBS2 Neurotic disorder Linked via 1 of 5 related genesPRSS55 Attention deficit hyperactivity disorder Linked via 1 of 5 related genesOGA Autism Linked via 1 of 5 related genesOGA

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Obesity	2	["PRSS55","KHDRBS2"]
Alzheimer disease	2	["OGA","KHDRBS2"]
Neurotic disorder	1	["PRSS55"]
Attention deficit hyperactivity disorder	1	["OGA"]
Autism	1	["OGA"]