Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	81544
Gene name	Glycerophosphodiester phosphodiesterase domain containing 5
Gene symbol	GDPD5
Synonyms (NCBI Gene)	GDE2PP1665
Chromosome	11
Chromosome location	11q13.4-q13.5
Summary	Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]

113 Show/Hide all (113)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051947	hsa-let-7b-5p	CLASH	23622248
MIRT049585	hsa-miR-92a-3p	CLASH	23622248
MIRT703343	hsa-miR-874-3p	HITS-CLIP	23313552
MIRT703342	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT703341	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT703340	hsa-miR-3943	HITS-CLIP	23313552
MIRT703339	hsa-miR-6760-5p	HITS-CLIP	23313552
MIRT703338	hsa-miR-3617-3p	HITS-CLIP	23313552
MIRT703337	hsa-miR-652-3p	HITS-CLIP	23313552
MIRT703336	hsa-miR-922	HITS-CLIP	23313552
MIRT703335	hsa-miR-214-3p	HITS-CLIP	23313552
MIRT703334	hsa-miR-3619-5p	HITS-CLIP	23313552
MIRT703333	hsa-miR-761	HITS-CLIP	23313552
MIRT703332	hsa-miR-4270	HITS-CLIP	23313552
MIRT703331	hsa-miR-4441	HITS-CLIP	23313552
MIRT703330	hsa-miR-6754-5p	HITS-CLIP	23313552
MIRT703329	hsa-miR-1205	HITS-CLIP	23313552
MIRT703328	hsa-miR-6889-3p	HITS-CLIP	23313552
MIRT703327	hsa-miR-1286	HITS-CLIP	23313552
MIRT703326	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT703325	hsa-miR-6132	HITS-CLIP	23313552
MIRT703324	hsa-miR-6836-5p	HITS-CLIP	23313552
MIRT703323	hsa-miR-1909-3p	HITS-CLIP	23313552
MIRT703322	hsa-miR-6722-3p	HITS-CLIP	23313552
MIRT703321	hsa-miR-7976	HITS-CLIP	23313552
MIRT703320	hsa-miR-3173-5p	HITS-CLIP	23313552
MIRT703319	hsa-miR-6799-3p	HITS-CLIP	23313552
MIRT703318	hsa-miR-146b-3p	HITS-CLIP	23313552
MIRT703317	hsa-miR-4683	HITS-CLIP	23313552
MIRT703316	hsa-miR-4291	HITS-CLIP	23313552
MIRT703315	hsa-miR-188-3p	HITS-CLIP	23313552
MIRT703343	hsa-miR-874-3p	HITS-CLIP	23313552
MIRT703342	hsa-miR-873-5p	HITS-CLIP	23313552
MIRT703341	hsa-miR-383-5p	HITS-CLIP	23313552
MIRT703340	hsa-miR-3943	HITS-CLIP	23313552
MIRT703339	hsa-miR-6760-5p	HITS-CLIP	23313552
MIRT703338	hsa-miR-3617-3p	HITS-CLIP	23313552
MIRT703337	hsa-miR-652-3p	HITS-CLIP	23313552
MIRT703336	hsa-miR-922	HITS-CLIP	23313552
MIRT703335	hsa-miR-214-3p	HITS-CLIP	23313552
MIRT703334	hsa-miR-3619-5p	HITS-CLIP	23313552
MIRT703333	hsa-miR-761	HITS-CLIP	23313552
MIRT703332	hsa-miR-4270	HITS-CLIP	23313552
MIRT703331	hsa-miR-4441	HITS-CLIP	23313552
MIRT703330	hsa-miR-6754-5p	HITS-CLIP	23313552
MIRT703329	hsa-miR-1205	HITS-CLIP	23313552
MIRT703328	hsa-miR-6889-3p	HITS-CLIP	23313552
MIRT703327	hsa-miR-1286	HITS-CLIP	23313552
MIRT703326	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT703325	hsa-miR-6132	HITS-CLIP	23313552
MIRT703324	hsa-miR-6836-5p	HITS-CLIP	23313552
MIRT703323	hsa-miR-1909-3p	HITS-CLIP	23313552
MIRT703322	hsa-miR-6722-3p	HITS-CLIP	23313552
MIRT703321	hsa-miR-7976	HITS-CLIP	23313552
MIRT703320	hsa-miR-3173-5p	HITS-CLIP	23313552
MIRT703319	hsa-miR-6799-3p	HITS-CLIP	23313552
MIRT703318	hsa-miR-146b-3p	HITS-CLIP	23313552
MIRT703317	hsa-miR-4683	HITS-CLIP	23313552
MIRT703316	hsa-miR-4291	HITS-CLIP	23313552
MIRT703315	hsa-miR-188-3p	HITS-CLIP	23313552
MIRT1016066	hsa-miR-1285	CLIP-seq
MIRT1016067	hsa-miR-1287	CLIP-seq
MIRT1016068	hsa-miR-218	CLIP-seq
MIRT1016069	hsa-miR-2278	CLIP-seq
MIRT1016070	hsa-miR-3135b	CLIP-seq
MIRT1016071	hsa-miR-3138	CLIP-seq
MIRT1016072	hsa-miR-3187-5p	CLIP-seq
MIRT1016073	hsa-miR-3622b-5p	CLIP-seq
MIRT1016074	hsa-miR-3660	CLIP-seq
MIRT1016075	hsa-miR-3672	CLIP-seq
MIRT1016076	hsa-miR-3945	CLIP-seq
MIRT1016077	hsa-miR-4253	CLIP-seq
MIRT1016078	hsa-miR-4468	CLIP-seq
MIRT1016079	hsa-miR-4499	CLIP-seq
MIRT1016080	hsa-miR-450b-3p	CLIP-seq
MIRT1016081	hsa-miR-4512	CLIP-seq
MIRT1016082	hsa-miR-4513	CLIP-seq
MIRT1016083	hsa-miR-4526	CLIP-seq
MIRT1016084	hsa-miR-4638-3p	CLIP-seq
MIRT1016085	hsa-miR-4700-3p	CLIP-seq
MIRT1016086	hsa-miR-4713-3p	CLIP-seq
MIRT1016087	hsa-miR-4716-3p	CLIP-seq
MIRT1016088	hsa-miR-4768-3p	CLIP-seq
MIRT1016089	hsa-miR-4800-5p	CLIP-seq
MIRT1016090	hsa-miR-544b	CLIP-seq
MIRT1016091	hsa-miR-612	CLIP-seq
MIRT1016092	hsa-miR-622	CLIP-seq
MIRT1016093	hsa-miR-636	CLIP-seq
MIRT1016094	hsa-miR-638	CLIP-seq
MIRT1016095	hsa-miR-769-3p	CLIP-seq
MIRT2000779	hsa-miR-1207-3p	CLIP-seq
MIRT2000780	hsa-miR-1289	CLIP-seq
MIRT2000781	hsa-miR-2467-5p	CLIP-seq
MIRT2000782	hsa-miR-2861	CLIP-seq
MIRT2000783	hsa-miR-3136-3p	CLIP-seq
MIRT2000784	hsa-miR-3664-3p	CLIP-seq
MIRT2000785	hsa-miR-3927	CLIP-seq
MIRT2000786	hsa-miR-4433	CLIP-seq
MIRT2000787	hsa-miR-4451	CLIP-seq
MIRT2000788	hsa-miR-4459	CLIP-seq
MIRT1016088	hsa-miR-4768-3p	CLIP-seq
MIRT2000789	hsa-miR-486-3p	CLIP-seq
MIRT2000783	hsa-miR-3136-3p	CLIP-seq
MIRT1016071	hsa-miR-3138	CLIP-seq
MIRT2234258	hsa-miR-335	CLIP-seq
MIRT2234259	hsa-miR-4701-5p	CLIP-seq
MIRT1016089	hsa-miR-4800-5p	CLIP-seq
MIRT2234260	hsa-miR-485-5p	CLIP-seq
MIRT1016090	hsa-miR-544b	CLIP-seq
MIRT2234261	hsa-miR-588	CLIP-seq
MIRT2234262	hsa-miR-604	CLIP-seq
MIRT1016092	hsa-miR-622	CLIP-seq
MIRT2388415	hsa-miR-1909	CLIP-seq

17 Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 26871637
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0008889	Function	Glycerophosphodiester phosphodiesterase activity	IBA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030426	Component	Growth cone	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IBA
GO:0047389	Function	Glycerophosphocholine phosphodiesterase activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

MIM	HGNC	e!Ensembl
609632	28804	ENSG00000158555

Q8WTR4

Protein name

Glycerophosphodiester phosphodiesterase domain-containing protein 5 (Glycerophosphocholine phosphodiesterase GDPD5) (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 2) (Phosphoinositide phospholipase C GDPD5) (EC 3.1.4.11)

Protein function

Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03009	GDPD	233 → 370	Glycerophosphoryl diester phosphodiesterase family	Family

Sequence

MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLTFTFGLTLTWLY
FWWEVHNDYDEFNWYLYNRMGYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNL
HWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHVGAVAAVTMLSWIVA
GQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLA
PEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASML
NWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAELLELAKGNATLLLNLR
DPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVAS
LRRGHIQRLNLRYTQVSRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHA
LSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVR
RTSRDVSIMKEKLIFSEISDGVEVSDVLSVCSDNSYDTYANSTATPVGPRGGGSHTKTLI
ERSGR

Sequence length

605

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	26621817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL DYSTROPHY	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	29212778	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	26621817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EYE DISEASE	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (16)
Alzheimer Disease	Alzheimer disease	Pubtator	33731436	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis, Familial	Amyotrophic lateral sclerosis	BEFREE	28103900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22279038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22279038, 27356959	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29635904		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	33924653	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22279038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22279038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	22279038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22279038		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	17275818		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	36430219	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	28103900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Refractory anemias	Anemia	BEFREE	17275818		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	17275818		★★★★★ ★☆☆☆☆ Found in Text Mining only

GDPD5 (glycerophosphodiester phosphodiesterase domain containing 5)

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