Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	8325
Gene name	Frizzled class receptor 8
Gene symbol	FZD8
Synonyms (NCBI Gene)	FZ-8hFZ8
Chromosome	10
Chromosome location	10p11.21
Summary	This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are couple

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miRTarBase ID	miRNA	Experiments	Reference
MIRT007255	hsa-miR-375	Luciferase reporter assay	23393589
MIRT007255	hsa-miR-375	Luciferase reporter assay	23396279
MIRT016029	hsa-miR-374b-5p	Sequencing	20371350
MIRT018441	hsa-miR-335-5p	Microarray	18185580
MIRT051873	hsa-let-7c-5p	CLASH	23622248
MIRT668238	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT668237	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT668236	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT668235	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT668234	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT668233	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT668231	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT668232	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT668230	hsa-miR-4433a-5p	HITS-CLIP	23824327
MIRT007255	hsa-miR-375	Luciferase reporter assayWestern blotting	32716585
MIRT668238	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT668237	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT668236	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT668235	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT668234	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT668233	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT668231	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT668232	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT668230	hsa-miR-4433a-5p	HITS-CLIP	23824327
MIRT1008571	hsa-miR-1261	CLIP-seq
MIRT1008572	hsa-miR-3188	CLIP-seq
MIRT1008573	hsa-miR-3201	CLIP-seq
MIRT1008574	hsa-miR-329	CLIP-seq
MIRT1008575	hsa-miR-362-3p	CLIP-seq
MIRT1008576	hsa-miR-3941	CLIP-seq
MIRT1008577	hsa-miR-4279	CLIP-seq
MIRT1008578	hsa-miR-4286	CLIP-seq
MIRT1008579	hsa-miR-4667-3p	CLIP-seq
MIRT1008580	hsa-miR-4755-3p	CLIP-seq
MIRT1008581	hsa-miR-4791	CLIP-seq
MIRT1008582	hsa-miR-603	CLIP-seq
MIRT1008583	hsa-miR-9	CLIP-seq
MIRT1998821	hsa-miR-2116	CLIP-seq
MIRT1998822	hsa-miR-4651	CLIP-seq
MIRT1998823	hsa-miR-4677-5p	CLIP-seq
MIRT1998824	hsa-miR-5095	CLIP-seq
MIRT1998825	hsa-miR-600	CLIP-seq
MIRT1998826	hsa-miR-608	CLIP-seq
MIRT2232517	hsa-miR-125a-3p	CLIP-seq
MIRT2232518	hsa-miR-150	CLIP-seq
MIRT2232519	hsa-miR-1915	CLIP-seq
MIRT2232520	hsa-miR-3200-5p	CLIP-seq
MIRT2232521	hsa-miR-345	CLIP-seq
MIRT1998822	hsa-miR-4651	CLIP-seq
MIRT1008579	hsa-miR-4667-3p	CLIP-seq
MIRT2232522	hsa-miR-4713-5p	CLIP-seq
MIRT2232523	hsa-miR-4726-3p	CLIP-seq
MIRT2232524	hsa-miR-532-3p	CLIP-seq
MIRT1998826	hsa-miR-608	CLIP-seq
MIRT2388314	hsa-miR-298	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	22682250
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	11295046
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0017147	Function	Wnt-protein binding	IBA
GO:0017147	Function	Wnt-protein binding	IEA
GO:0030165	Function	PDZ domain binding	IEA
GO:0030165	Function	PDZ domain binding	IPI	18256285
GO:0030182	Process	Neuron differentiation	ISS
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	22575959
GO:0033077	Process	T cell differentiation in thymus	IEA
GO:0035567	Process	Non-canonical Wnt signaling pathway	IBA
GO:0042813	Function	Wnt receptor activity	IBA
GO:0042813	Function	Wnt receptor activity	IDA	28733458
GO:0042813	Function	Wnt receptor activity	IEA
GO:0042813	Function	Wnt receptor activity	TAS	11295046
GO:0060070	Process	Canonical Wnt signaling pathway	IBA
GO:0060070	Process	Canonical Wnt signaling pathway	IDA	28733458
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IEA
GO:0060070	Process	Canonical Wnt signaling pathway	IMP	22138402
GO:0098992	Component	Neuronal dense core vesicle	IEA
GO:1990851	Component	Wnt-Frizzled-LRP5/6 complex	IEA

MIM	HGNC	e!Ensembl
606146	4046	ENSG00000177283

Q9H461

Protein name

Frizzled-8 (Fz-8) (hFz8)

Protein function

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway l

PDB

5UN5 , 5UN6 , 6NDZ , 8X0T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01392	Fz	35 → 143	Fz domain	Domain
PF01534	Frizzled	268 → 620	Frizzled/Smoothened family membrane region	Family

Tissue specificity

TISSUE SPECIFICITY: Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.

Sequence

MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGS
GHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVS
VSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFL
IDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGA
GAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLT
WFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDN
LRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLY
TVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITS
GVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGG
GGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV

Sequence length

694

Interactions

View interactions

KEGG Pathway	Reactome Pathway
mTOR signaling pathway	Asymmetric localization of PCP proteins
Wnt signaling pathway	Regulation of FZD by ubiquitination
Hippo signaling pathway	RNF mutants show enhanced WNT signaling and proliferation
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
FZD5	[]	14	["mTOR signaling pathway","Wnt signaling pathway","Hippo signaling pathway","Signaling pathways regulating pluripotency of stem cells","Melanogenesis","Cushing syndrome","Proteoglycans in cancer","Basal cell carcinoma","Breast cancer","Hepatocellular carcinoma","Gastric cancer","Asymmetric localization of PCP proteins"]	[]
FZD6	[]	13	["mTOR signaling pathway","Wnt signaling pathway","Hippo signaling pathway","Signaling pathways regulating pluripotency of stem cells","Melanogenesis","Cushing syndrome","Proteoglycans in cancer","Basal cell carcinoma","Breast cancer","Hepatocellular carcinoma","Gastric cancer","Regulation of FZD by ubiquitination"]	[]
FZD10	[]	11	["mTOR signaling pathway","Wnt signaling pathway","Hippo signaling pathway","Signaling pathways regulating pluripotency of stem cells","Melanogenesis","Cushing syndrome","Proteoglycans in cancer","Basal cell carcinoma","Breast cancer","Hepatocellular carcinoma","Gastric cancer"]	[]
FZD9	[]	11	["mTOR signaling pathway","Wnt signaling pathway","Hippo signaling pathway","Signaling pathways regulating pluripotency of stem cells","Melanogenesis","Cushing syndrome","Proteoglycans in cancer","Basal cell carcinoma","Breast cancer","Hepatocellular carcinoma","Gastric cancer"]	[]
FZD4	[]	14	["mTOR signaling pathway","Wnt signaling pathway","Hippo signaling pathway","Signaling pathways regulating pluripotency of stem cells","Melanogenesis","Cushing syndrome","Proteoglycans in cancer","Basal cell carcinoma","Breast cancer","Hepatocellular carcinoma","Gastric cancer","Asymmetric localization of PCP proteins"]	[]

FZD8 (frizzled class receptor 8)

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