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Gene Gene information from NCBI Gene database.
Entrez ID 2319
Gene name Flotillin 2
Gene symbol FLOT2
Synonyms (NCBI Gene)
ECS-1ECS1ESAESA1M17S1
Chromosome 17
Chromosome location 17q11.2
Summary Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, J
miRNA miRNA information provided by mirtarbase database.
422 Show/Hide all (422)
miRTarBase ID miRNA Experiments Reference
MIRT019295 hsa-miR-148b-3p Microarray 17612493
MIRT022325 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023557 hsa-miR-1-3p Proteomics 18668040
MIRT023557 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT042495 hsa-miR-423-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
56 Show/Hide all (56)
GO ID Ontology Definition Evidence Reference
GO:0001931 Component Uropod IDA 21696602
GO:0001931 Component Uropod IEA
GO:0002020 Function Protease binding IBA
GO:0002080 Component Acrosomal membrane IEA
GO:0005515 Function Protein binding IPI 17113085, 21119006, 21696602, 24167781, 24809731, 25229320, 30021884
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
131560 3758 ENSG00000132589
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14254
Protein name Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)
Protein function May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01145 Band_7 5 → 188 SPFH domain / Band 7 family Family
PF15975 Flot 311 → 422 Flotillin Family
Tissue specificity TISSUE SPECIFICITY: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed i
Sequence
Sequence length 428
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Insulin signaling pathway Synaptic adhesion-like molecules