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Gene Gene information from NCBI Gene database.
Entrez ID 2252
Gene name Fibroblast growth factor 7
Gene symbol FGF7
Synonyms (NCBI Gene)
HBGF-7KGF
Chromosome 15
Chromosome location 15q21.2
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cel
miRNA miRNA information provided by mirtarbase database.
799 Show/Hide all (799)
miRTarBase ID miRNA Experiments Reference
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19701459
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19701459
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19701459
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19177201
MIRT003482 hsa-miR-155-5p Review 20026422
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
JUN Unknown 15840658
NFKB1 Unknown 9869450
RELA Unknown 9869450
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49 Show/Hide all (49)
GO ID Ontology Definition Evidence Reference
GO:0001935 Process Endothelial cell proliferation IEA
GO:0001938 Process Positive regulation of endothelial cell proliferation IEA
GO:0005111 Function Type 2 fibroblast growth factor receptor binding IBA
GO:0005515 Function Protein binding IPI 1309608
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
148180 3685 ENSG00000140285
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P21781
Protein name Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor)
Protein function Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00167 FGF 65 → 189 Fibroblast growth factor Domain
Tissue specificity TISSUE SPECIFICITY: Epithelial cell.
Sequence
Sequence length 194
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
MAPK signaling pathway PI3K Cascade
Ras signaling pathway PIP3 activates AKT signaling
Rap1 signaling pathway FGFR2b ligand binding and activation
Calcium signaling pathway Activated point mutants of FGFR2
PI3K-Akt signaling pathway Constitutive Signaling by Aberrant PI3K in Cancer
Regulation of actin cytoskeleton Phospholipase C-mediated cascade; FGFR2
Pathways in cancer PI-3K cascade:FGFR2
Chemical carcinogenesis - receptor activation SHC-mediated cascade:FGFR2
Melanoma FRS-mediated FGFR2 signaling
Breast cancer Negative regulation of FGFR2 signaling
Gastric cancer Signaling by FGFR2 in disease
  RAF/MAP kinase cascade
  PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (13)
Phenotype Name Clinical Significance Source Reference Evidence Score
CLEFT LIP — CTD 17963255
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLEFT PALATE — CTD, Disgenet
CTD, Disgenet
17963255
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLEFT UPPER LIP — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COMPLETE UNILATERAL CLEFT LIP — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GINGIVAL HYPERPLASIA — CTD 11023675
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (158)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 8759054, 9070494
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma GWASCAT_DG 28604730
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Rickets Rickets BEFREE 25165185
★★★★★
★☆☆☆☆
Found in Text Mining only
Alopecia Alopecia BEFREE 29693180
★★★★★
★☆☆☆☆
Found in Text Mining only
Alveolitis, Fibrosing Alveolitis CTD_human_DG 15677771
★★★★★
★☆☆☆☆
Found in Text Mining only
Ameloblastoma Ameloblastoma BEFREE 24002438
★★★★★
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 17525264
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 39342401 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Ataxia telangiectasia Pubtator 26587829 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 29707971
★★★★★
★☆☆☆☆
Found in Text Mining only