Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	2134
Gene name	Exostosin like glycosyltransferase 1
Gene symbol	EXTL1
Synonyms (NCBI Gene)	EXTL
Chromosome	1
Chromosome location	1p36.11
Summary	This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involv

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miRTarBase ID	miRNA	Experiments
MIRT973532	hsa-miR-10a	CLIP-seq
MIRT973533	hsa-miR-10b	CLIP-seq
MIRT973534	hsa-miR-1228	CLIP-seq
MIRT973535	hsa-miR-1229	CLIP-seq
MIRT973536	hsa-miR-136	CLIP-seq
MIRT973537	hsa-miR-3135	CLIP-seq
MIRT973538	hsa-miR-3189-3p	CLIP-seq
MIRT973539	hsa-miR-339-5p	CLIP-seq
MIRT973540	hsa-miR-3620	CLIP-seq
MIRT973541	hsa-miR-4258	CLIP-seq
MIRT973542	hsa-miR-4268	CLIP-seq
MIRT973543	hsa-miR-4448	CLIP-seq
MIRT973544	hsa-miR-4449	CLIP-seq
MIRT973545	hsa-miR-4632	CLIP-seq
MIRT973546	hsa-miR-4676-5p	CLIP-seq
MIRT973547	hsa-miR-575	CLIP-seq
MIRT973548	hsa-miR-767-3p	CLIP-seq
MIRT1988422	hsa-miR-2116	CLIP-seq
MIRT1988423	hsa-miR-2467-5p	CLIP-seq
MIRT973539	hsa-miR-339-5p	CLIP-seq
MIRT1988424	hsa-miR-3942-3p	CLIP-seq
MIRT973541	hsa-miR-4258	CLIP-seq
MIRT973544	hsa-miR-4449	CLIP-seq
MIRT973545	hsa-miR-4632	CLIP-seq
MIRT1988425	hsa-miR-4677-5p	CLIP-seq
MIRT973532	hsa-miR-10a	CLIP-seq
MIRT973533	hsa-miR-10b	CLIP-seq
MIRT973534	hsa-miR-1228	CLIP-seq
MIRT973537	hsa-miR-3135	CLIP-seq
MIRT973539	hsa-miR-339-5p	CLIP-seq
MIRT973540	hsa-miR-3620	CLIP-seq
MIRT973541	hsa-miR-4258	CLIP-seq
MIRT973544	hsa-miR-4449	CLIP-seq
MIRT973545	hsa-miR-4632	CLIP-seq
MIRT973546	hsa-miR-4676-5p	CLIP-seq
MIRT973547	hsa-miR-575	CLIP-seq
MIRT2680404	hsa-miR-2114	CLIP-seq
MIRT2680405	hsa-miR-3150b-3p	CLIP-seq
MIRT2680406	hsa-miR-4254	CLIP-seq
MIRT2680407	hsa-miR-4292	CLIP-seq
MIRT2680408	hsa-miR-4308	CLIP-seq
MIRT2680409	hsa-miR-4645-5p	CLIP-seq
MIRT2680410	hsa-miR-4673	CLIP-seq
MIRT2680411	hsa-miR-4742-5p	CLIP-seq
MIRT2680412	hsa-miR-4784	CLIP-seq
MIRT2680413	hsa-miR-765	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	TAS	9037597
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IBA
GO:0006486	Process	Protein glycosylation	IEA
GO:0008375	Function	Acetylglucosaminyltransferase activity	IBA
GO:0008375	Function	Acetylglucosaminyltransferase activity	IEA
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IDA	11390981
GO:0015012	Process	Heparan sulfate proteoglycan biosynthetic process	IEA
GO:0015020	Function	Glucuronosyltransferase activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0050508	Function	Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IDA	11390981
GO:0050508	Function	Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IEA

MIM	HGNC	e!Ensembl
601738	3515	ENSG00000158008

Q92935

Protein name

Exostosin-like 1 (EC 2.4.1.224) (Exostosin-L) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein)

Protein function

Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS) (PubMed:11390981). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) (PubMed:11390981). Appears to lack GlcNAcT I and GlcAT-II activitie

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03016	Exostosin	88 → 335	Exostosin family	Family
PF09258	Glyco_transf_64	419 → 659	Glycosyl transferase family 64 domain	Domain

Sequence

MQSWRRRKSLWLALSASWLLLVLLGGFSLLRLALPPRPRPGASQGWPRWLDAELLQSFSQ
PGELPEDAVSPPQAPHGGSCNWESCFDTSKCRGDGLKVFVYPAVGTISETHRRILASIEG
SRFYTFSPAGACLLLLLSLDAQTGECSSMPLQWNRGRNHLVLRLHPAPCPRTFQLGQAMV
AEASPTVDSFRPGFDVALPFLPEAHPLRGGAPGQLRQHSPQPGVALLALEEERGGWRTAD
TGSSACPWDGRCEQDPGPGQTQRQETLPNATFCLISGHRPEAASRFLQALQAGCIPVLLS
PRWELPFSEVIDWTKAAIVADERLPLQVLAALQEMSPARVLALRQQTQFLWDAYFSSVEK
VIHTTLEVIQDRIFGTSAHPSLLWNSPPGALLALSTFSTSPQDFPFYYLQQGSRPEGRFS
ALIWVGPPGQPPLKLIQAVAGSQHCAQILVLWSNERPLPSRWPETAVPLTVIDGHRKVSD
RFYPYSTIRTDAILSLDARSSLSTSEVDFAFLVWQSFPERMVGFLTSSHFWDEAHGGWGY
TAERTNEFSMVLTTAAFYHRYYHTLFTHSLPKALRTLADEAPTCVDVLMNFIVAAVTKLP
PIKVPYGKQRQEAAPLAPGGPGPRPKPPAPAPDCINQIAAAFGHMPLLSSRLRLDPVLFK
DPVSVQRKKYRSLEKP

Sequence length

676

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glycosaminoglycan biosynthesis - heparan sulfate / heparin	XBP1(S) activates chaperone genes
Metabolic pathways

EXTL1 (exostosin like glycosyltransferase 1)

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