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Gene Gene information from NCBI Gene database.
Entrez ID 2005
Gene name ETS transcription factor ELK4
Gene symbol ELK4
Synonyms (NCBI Gene)
SAP1
Chromosome 1
Chromosome location 1q32.1
Summary This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promo
miRNA miRNA information provided by mirtarbase database.
2272 Show/Hide all (2272)
miRTarBase ID miRNA Experiments Reference
MIRT052289 hsa-let-7b-5p CLASH 23622248
MIRT041755 hsa-miR-484 CLASH 23622248
MIRT616985 hsa-miR-8485 HITS-CLIP 23824327
MIRT183809 hsa-miR-181a-5p HITS-CLIP 23824327
MIRT183810 hsa-miR-181b-5p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
AR Unknown 18469865
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24 Show/Hide all (24)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 22722849
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 11846562
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600246 3326 ENSG00000158711
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P28324
Protein name ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)
Protein function Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repressio
PDB 1BC7 , 1BC8 , 1HBX , 1K6O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00178 Ets 6 → 85 Ets-domain Domain
Sequence
MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLS
RALRYYYVKNIIKKVNGQKFVYKFV
SYPEILNMDPMTVGRIEGDCESLNFSEVSSSSKDV
ENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNVKLFKLIKTENPAEKLAEKKS
PQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSSEETIQALETLVSPKLPSLEAPT
SASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHPDIDTDIDSVASQPMELPENLSLEP
KDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVITSSDPSPLGILSPSLPTASLTPAFFSQ
TPIILTPSPLLSSIHFWSTLSPVAPLSPARLQGANTLFQFPSVLNSHGPFTLSGLDGPST
PGPFSPDLQKT
Sequence length 431
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
MAPK signaling pathway
Human T-cell leukemia virus 1 infection
Transcriptional misregulation in cancer