DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10294 |
| Gene name | DnaJ heat shock protein family (Hsp40) member A2 |
| Gene symbol | DNAJA2 |
| Synonyms (NCBI Gene) |
CPR3DJ3DJA2DNAJDNJ3HIRIP4PRO3015RDJ2
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| Chromosome | 16 |
| Chromosome location | 16q11.2 |
| Summary | The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O60884 | ||||||||||||||||||||
| Protein name | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | ||||||||||||||||||||
| Protein function | Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). | ||||||||||||||||||||
| PDB | 7ZHS | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MANVADTKLYDILGVPPGASENELKKAYRKLAKEYHPDKNPNAGDKFKEISFAYEVLSNP |
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| Sequence length | 412 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with DNAJA2 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to DNAJA2 (see Related Genes above), that are NOT already directly curated for DNAJA2 itself -- a lead worth checking, not a confirmed association.
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