DFFB (DNA fragmentation factor subunit beta)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1677
• Gene name: DNA fragmentation factor subunit beta
• Gene symbol: DFFB
• Synonyms (NCBI Gene): CAD, CPAN, DFF-40, DFF2, DFF40
• Chromosome: 1
• Chromosome location: 1p36.32
• Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal uni

miRNA Show/Hide all (252)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002560	hsa-miR-124-3p	Microarray	15685193
MIRT002560	hsa-miR-124-3p	Microarray	18668037
MIRT002560	hsa-miR-124-3p	Microarray	15685193
MIRT039441	hsa-miR-421	CLASH	23622248
MIRT709662	hsa-miR-4428	HITS-CLIP	19536157
MIRT709661	hsa-miR-1255b-2-3p	HITS-CLIP	19536157
MIRT709660	hsa-miR-4476	HITS-CLIP	19536157
MIRT709659	hsa-miR-6876-5p	HITS-CLIP	19536157
MIRT709658	hsa-miR-3929	HITS-CLIP	19536157
MIRT709657	hsa-miR-4419b	HITS-CLIP	19536157
MIRT709656	hsa-miR-4478	HITS-CLIP	19536157
MIRT709655	hsa-miR-589-5p	HITS-CLIP	19536157
MIRT709654	hsa-miR-3928-3p	HITS-CLIP	19536157
MIRT709653	hsa-miR-485-5p	HITS-CLIP	19536157
MIRT709652	hsa-miR-6884-5p	HITS-CLIP	19536157
MIRT709651	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709650	hsa-miR-4533	HITS-CLIP	19536157
MIRT709649	hsa-miR-3915	HITS-CLIP	19536157
MIRT709648	hsa-miR-665	HITS-CLIP	19536157
MIRT709662	hsa-miR-4428	HITS-CLIP	19536157
MIRT709661	hsa-miR-1255b-2-3p	HITS-CLIP	19536157
MIRT709660	hsa-miR-4476	HITS-CLIP	19536157
MIRT709659	hsa-miR-6876-5p	HITS-CLIP	19536157
MIRT709658	hsa-miR-3929	HITS-CLIP	19536157
MIRT709657	hsa-miR-4419b	HITS-CLIP	19536157
MIRT709656	hsa-miR-4478	HITS-CLIP	19536157
MIRT709655	hsa-miR-589-5p	HITS-CLIP	19536157
MIRT709654	hsa-miR-3928-3p	HITS-CLIP	19536157
MIRT709653	hsa-miR-485-5p	HITS-CLIP	19536157
MIRT709652	hsa-miR-6884-5p	HITS-CLIP	19536157
MIRT709651	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709650	hsa-miR-4533	HITS-CLIP	19536157
MIRT709649	hsa-miR-3915	HITS-CLIP	19536157
MIRT709648	hsa-miR-665	HITS-CLIP	19536157
MIRT933481	hsa-miR-1228	CLIP-seq
MIRT933482	hsa-miR-1268	CLIP-seq
MIRT933483	hsa-miR-1268b	CLIP-seq
MIRT933484	hsa-miR-1299	CLIP-seq
MIRT933485	hsa-miR-145	CLIP-seq
MIRT933486	hsa-miR-2115	CLIP-seq
MIRT933487	hsa-miR-3122	CLIP-seq
MIRT933488	hsa-miR-3147	CLIP-seq
MIRT933489	hsa-miR-3622a-3p	CLIP-seq
MIRT933490	hsa-miR-3622b-3p	CLIP-seq
MIRT933491	hsa-miR-3672	CLIP-seq
MIRT933492	hsa-miR-3689a-3p	CLIP-seq
MIRT933493	hsa-miR-3689c	CLIP-seq
MIRT933494	hsa-miR-3909	CLIP-seq
MIRT933495	hsa-miR-3913-5p	CLIP-seq
MIRT933496	hsa-miR-3926	CLIP-seq
MIRT933497	hsa-miR-3928	CLIP-seq
MIRT933498	hsa-miR-4259	CLIP-seq
MIRT933499	hsa-miR-4293	CLIP-seq
MIRT933500	hsa-miR-4433	CLIP-seq
MIRT933501	hsa-miR-4459	CLIP-seq
MIRT933502	hsa-miR-4672	CLIP-seq
MIRT933503	hsa-miR-4684-5p	CLIP-seq
MIRT933504	hsa-miR-4711-5p	CLIP-seq
MIRT933505	hsa-miR-4728-5p	CLIP-seq
MIRT933506	hsa-miR-4768-3p	CLIP-seq
MIRT933507	hsa-miR-4773	CLIP-seq
MIRT933508	hsa-miR-4786-5p	CLIP-seq
MIRT933509	hsa-miR-4793-3p	CLIP-seq
MIRT933510	hsa-miR-4797-5p	CLIP-seq
MIRT933511	hsa-miR-541	CLIP-seq
MIRT933512	hsa-miR-544b	CLIP-seq
MIRT933513	hsa-miR-548c-3p	CLIP-seq
MIRT933514	hsa-miR-548s	CLIP-seq
MIRT933515	hsa-miR-589	CLIP-seq
MIRT933516	hsa-miR-654-5p	CLIP-seq
MIRT933517	hsa-miR-759	CLIP-seq
MIRT933518	hsa-miR-766	CLIP-seq
MIRT933519	hsa-miR-769-5p	CLIP-seq
MIRT933520	hsa-miR-875-3p	CLIP-seq
MIRT933521	hsa-miR-890	CLIP-seq
MIRT933481	hsa-miR-1228	CLIP-seq
MIRT1976324	hsa-miR-138	CLIP-seq
MIRT1976325	hsa-miR-24	CLIP-seq
MIRT933487	hsa-miR-3122	CLIP-seq
MIRT1976326	hsa-miR-3155	CLIP-seq
MIRT1976327	hsa-miR-3155b	CLIP-seq
MIRT1976328	hsa-miR-3178	CLIP-seq
MIRT1976329	hsa-miR-342-3p	CLIP-seq
MIRT933489	hsa-miR-3622a-3p	CLIP-seq
MIRT933490	hsa-miR-3622b-3p	CLIP-seq
MIRT933491	hsa-miR-3672	CLIP-seq
MIRT933492	hsa-miR-3689a-3p	CLIP-seq
MIRT933493	hsa-miR-3689c	CLIP-seq
MIRT933495	hsa-miR-3913-5p	CLIP-seq
MIRT933496	hsa-miR-3926	CLIP-seq
MIRT1976330	hsa-miR-4258	CLIP-seq
MIRT1976331	hsa-miR-4284	CLIP-seq
MIRT933499	hsa-miR-4293	CLIP-seq
MIRT1976332	hsa-miR-4299	CLIP-seq
MIRT933500	hsa-miR-4433	CLIP-seq
MIRT933501	hsa-miR-4459	CLIP-seq
MIRT1976333	hsa-miR-4486	CLIP-seq
MIRT1976334	hsa-miR-4505	CLIP-seq
MIRT933505	hsa-miR-4728-5p	CLIP-seq
MIRT933506	hsa-miR-4768-3p	CLIP-seq
MIRT933507	hsa-miR-4773	CLIP-seq
MIRT933508	hsa-miR-4786-5p	CLIP-seq
MIRT1976335	hsa-miR-484	CLIP-seq
MIRT933511	hsa-miR-541	CLIP-seq
MIRT933512	hsa-miR-544b	CLIP-seq
MIRT933514	hsa-miR-548s	CLIP-seq
MIRT933516	hsa-miR-654-5p	CLIP-seq
MIRT933519	hsa-miR-769-5p	CLIP-seq
MIRT1976336	hsa-miR-922	CLIP-seq
MIRT933481	hsa-miR-1228	CLIP-seq
MIRT933482	hsa-miR-1268	CLIP-seq
MIRT933483	hsa-miR-1268b	CLIP-seq
MIRT1976325	hsa-miR-24	CLIP-seq
MIRT933487	hsa-miR-3122	CLIP-seq
MIRT1976329	hsa-miR-342-3p	CLIP-seq
MIRT933489	hsa-miR-3622a-3p	CLIP-seq
MIRT933490	hsa-miR-3622b-3p	CLIP-seq
MIRT933491	hsa-miR-3672	CLIP-seq
MIRT933492	hsa-miR-3689a-3p	CLIP-seq
MIRT933493	hsa-miR-3689c	CLIP-seq
MIRT933495	hsa-miR-3913-5p	CLIP-seq
MIRT933496	hsa-miR-3926	CLIP-seq
MIRT933497	hsa-miR-3928	CLIP-seq
MIRT1976331	hsa-miR-4284	CLIP-seq
MIRT933499	hsa-miR-4293	CLIP-seq
MIRT933500	hsa-miR-4433	CLIP-seq
MIRT933501	hsa-miR-4459	CLIP-seq
MIRT2211761	hsa-miR-4537	CLIP-seq
MIRT933503	hsa-miR-4684-5p	CLIP-seq
MIRT933504	hsa-miR-4711-5p	CLIP-seq
MIRT933505	hsa-miR-4728-5p	CLIP-seq
MIRT933506	hsa-miR-4768-3p	CLIP-seq
MIRT933507	hsa-miR-4773	CLIP-seq
MIRT933508	hsa-miR-4786-5p	CLIP-seq
MIRT933509	hsa-miR-4793-3p	CLIP-seq
MIRT933510	hsa-miR-4797-5p	CLIP-seq
MIRT933511	hsa-miR-541	CLIP-seq
MIRT933512	hsa-miR-544b	CLIP-seq
MIRT933513	hsa-miR-548c-3p	CLIP-seq
MIRT933514	hsa-miR-548s	CLIP-seq
MIRT933515	hsa-miR-589	CLIP-seq
MIRT933516	hsa-miR-654-5p	CLIP-seq
MIRT933517	hsa-miR-759	CLIP-seq
MIRT933518	hsa-miR-766	CLIP-seq
MIRT933519	hsa-miR-769-5p	CLIP-seq
MIRT933521	hsa-miR-890	CLIP-seq
MIRT933489	hsa-miR-3622a-3p	CLIP-seq
MIRT933490	hsa-miR-3622b-3p	CLIP-seq
MIRT1976330	hsa-miR-4258	CLIP-seq
MIRT933499	hsa-miR-4293	CLIP-seq
MIRT933508	hsa-miR-4786-5p	CLIP-seq
MIRT933509	hsa-miR-4793-3p	CLIP-seq
MIRT933510	hsa-miR-4797-5p	CLIP-seq
MIRT933512	hsa-miR-544b	CLIP-seq
MIRT933517	hsa-miR-759	CLIP-seq
MIRT933518	hsa-miR-766	CLIP-seq
MIRT933519	hsa-miR-769-5p	CLIP-seq
MIRT933481	hsa-miR-1228	CLIP-seq
MIRT933487	hsa-miR-3122	CLIP-seq
MIRT933492	hsa-miR-3689a-3p	CLIP-seq
MIRT933493	hsa-miR-3689c	CLIP-seq
MIRT933495	hsa-miR-3913-5p	CLIP-seq
MIRT933505	hsa-miR-4728-5p	CLIP-seq
MIRT2515520	hsa-miR-10a	CLIP-seq
MIRT2515521	hsa-miR-10b	CLIP-seq
MIRT2515522	hsa-miR-1207-3p	CLIP-seq
MIRT933481	hsa-miR-1228	CLIP-seq
MIRT933482	hsa-miR-1268	CLIP-seq
MIRT933483	hsa-miR-1268b	CLIP-seq
MIRT2515523	hsa-miR-143	CLIP-seq
MIRT2515524	hsa-miR-22	CLIP-seq
MIRT933487	hsa-miR-3122	CLIP-seq
MIRT2515525	hsa-miR-339-5p	CLIP-seq
MIRT2515526	hsa-miR-3613-3p	CLIP-seq
MIRT933489	hsa-miR-3622a-3p	CLIP-seq
MIRT933490	hsa-miR-3622b-3p	CLIP-seq
MIRT2515527	hsa-miR-3646	CLIP-seq
MIRT2515528	hsa-miR-3670	CLIP-seq
MIRT933491	hsa-miR-3672	CLIP-seq
MIRT2515529	hsa-miR-3682-3p	CLIP-seq
MIRT933492	hsa-miR-3689a-3p	CLIP-seq
MIRT933493	hsa-miR-3689c	CLIP-seq
MIRT2515530	hsa-miR-371-5p	CLIP-seq
MIRT2515531	hsa-miR-371b-5p	CLIP-seq
MIRT2515532	hsa-miR-380	CLIP-seq
MIRT933495	hsa-miR-3913-5p	CLIP-seq
MIRT933499	hsa-miR-4293	CLIP-seq
MIRT2515533	hsa-miR-4325	CLIP-seq
MIRT2515534	hsa-miR-4328	CLIP-seq
MIRT2515535	hsa-miR-4421	CLIP-seq
MIRT933500	hsa-miR-4433	CLIP-seq
MIRT2515536	hsa-miR-4454	CLIP-seq
MIRT933501	hsa-miR-4459	CLIP-seq
MIRT2515537	hsa-miR-4495	CLIP-seq
MIRT2515538	hsa-miR-450b-5p	CLIP-seq
MIRT933503	hsa-miR-4684-5p	CLIP-seq
MIRT2515539	hsa-miR-4725-5p	CLIP-seq
MIRT933505	hsa-miR-4728-5p	CLIP-seq
MIRT933506	hsa-miR-4768-3p	CLIP-seq
MIRT2515540	hsa-miR-4770	CLIP-seq
MIRT933508	hsa-miR-4786-5p	CLIP-seq
MIRT2515541	hsa-miR-495	CLIP-seq
MIRT2515542	hsa-miR-504	CLIP-seq
MIRT2515543	hsa-miR-507	CLIP-seq
MIRT933511	hsa-miR-541	CLIP-seq
MIRT933512	hsa-miR-544b	CLIP-seq
MIRT933513	hsa-miR-548c-3p	CLIP-seq
MIRT2515544	hsa-miR-556-5p	CLIP-seq
MIRT2515545	hsa-miR-557	CLIP-seq
MIRT2515546	hsa-miR-570	CLIP-seq
MIRT2515547	hsa-miR-642b	CLIP-seq
MIRT933516	hsa-miR-654-5p	CLIP-seq
MIRT933519	hsa-miR-769-5p	CLIP-seq
MIRT2515548	hsa-miR-802	CLIP-seq
MIRT2515520	hsa-miR-10a	CLIP-seq
MIRT2515521	hsa-miR-10b	CLIP-seq
MIRT933481	hsa-miR-1228	CLIP-seq
MIRT933482	hsa-miR-1268	CLIP-seq
MIRT933483	hsa-miR-1268b	CLIP-seq
MIRT2515523	hsa-miR-143	CLIP-seq
MIRT933487	hsa-miR-3122	CLIP-seq
MIRT2515525	hsa-miR-339-5p	CLIP-seq
MIRT2515526	hsa-miR-3613-3p	CLIP-seq
MIRT933489	hsa-miR-3622a-3p	CLIP-seq
MIRT933490	hsa-miR-3622b-3p	CLIP-seq
MIRT2515528	hsa-miR-3670	CLIP-seq
MIRT933491	hsa-miR-3672	CLIP-seq
MIRT2515529	hsa-miR-3682-3p	CLIP-seq
MIRT933492	hsa-miR-3689a-3p	CLIP-seq
MIRT933493	hsa-miR-3689c	CLIP-seq
MIRT2515530	hsa-miR-371-5p	CLIP-seq
MIRT2515531	hsa-miR-371b-5p	CLIP-seq
MIRT933495	hsa-miR-3913-5p	CLIP-seq
MIRT2515535	hsa-miR-4421	CLIP-seq
MIRT933500	hsa-miR-4433	CLIP-seq
MIRT2515536	hsa-miR-4454	CLIP-seq
MIRT933501	hsa-miR-4459	CLIP-seq
MIRT933503	hsa-miR-4684-5p	CLIP-seq
MIRT2515539	hsa-miR-4725-5p	CLIP-seq
MIRT933505	hsa-miR-4728-5p	CLIP-seq
MIRT933506	hsa-miR-4768-3p	CLIP-seq
MIRT2515540	hsa-miR-4770	CLIP-seq
MIRT933508	hsa-miR-4786-5p	CLIP-seq
MIRT2515541	hsa-miR-495	CLIP-seq
MIRT2515542	hsa-miR-504	CLIP-seq
MIRT933511	hsa-miR-541	CLIP-seq
MIRT933512	hsa-miR-544b	CLIP-seq
MIRT933513	hsa-miR-548c-3p	CLIP-seq
MIRT2515544	hsa-miR-556-5p	CLIP-seq
MIRT933516	hsa-miR-654-5p	CLIP-seq
MIRT933519	hsa-miR-769-5p	CLIP-seq
MIRT2515548	hsa-miR-802	CLIP-seq

Gene ontology (GO) Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	19882353, 22253444
GO:0003677	Function	DNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IEA
GO:0004536	Function	DNA nuclease activity	IBA
GO:0004536	Function	DNA nuclease activity	IMP	19944011
GO:0004536	Function	DNA nuclease activity	TAS	9671700
GO:0005515	Function	Protein binding	IPI	11371636, 19882353, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	10959840, 15572351, 22253444
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	9108473, 22253444
GO:0005829	Component	Cytosol	TAS
GO:0006308	Process	DNA catabolic process	IMP	19944011
GO:0006309	Process	Apoptotic DNA fragmentation	IBA
GO:0006309	Process	Apoptotic DNA fragmentation	IDA	15572351
GO:0006309	Process	Apoptotic DNA fragmentation	IDA	22253444
GO:0006309	Process	Apoptotic DNA fragmentation	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019899	Function	Enzyme binding	IPI	10959840
GO:0019904	Function	Protein domain specific binding	IPI	19944011
GO:0030263	Process	Apoptotic chromosome condensation	IDA	10959840
GO:0032991	Component	Protein-containing complex	IDA	11371636
GO:0042802	Function	Identical protein binding	IPI	11371636
GO:0097718	Function	Disordered domain specific binding	IPI	11371636
GO:1902511	Process	Negative regulation of apoptotic DNA fragmentation	IDA	11371636

Other IDs

• MIM: 601883
• HGNC: 2773
• e!Ensembl: ENSG00000169598

Protein

• UniProt ID: O76075
• Protein name: DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (Caspase-activated nuclease) (CPAN) (DNA fragmentation factor 40 kDa subunit) (DFF-40)
• Protein function: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
• PDB: 1IBX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02017	CIDE-N	5 → 79	CIDE-N domain	Domain
  PF09230	DFF40	100 → 323	DNA fragmentation factor 40 kDa	Domain

• Sequence:

  MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTEDYF
  PSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQRLLA
  DLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSYPSTVGA
  EAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHS
  INPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLK
  LVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPVRKRQ

• Sequence length: 338

Pathways

KEGG Pathway:

Apoptosis

Reactome Pathway:

Apoptosis induced DNA fragmentation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

DFFA 2 shared pathwaysApoptosis, Apoptosis induced DNA fragmentation Related via 2 shared pathways including Apoptosis, Apoptosis induced DNA fragmentation. CASP3 2 shared pathwaysApoptosis, Apoptosis induced DNA fragmentation Related via 2 shared pathways including Apoptosis, Apoptosis induced DNA fragmentation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
DFFA	0	[]	2	["Apoptosis","Apoptosis induced DNA fragmentation"]	0	[]
CASP3	0	[]	2	["Apoptosis","Apoptosis induced DNA fragmentation"]	0	[]

Diseases Linked via Similar Genes

Major depressive disorder Linked via 1 of 2 related genesDFFA Alzheimer disease Linked via 1 of 2 related genesCASP3 Brain ischemia Linked via 1 of 2 related genesCASP3 Calcinosis Linked via 1 of 2 related genesCASP3 Cerebral hemorrhage Linked via 1 of 2 related genesCASP3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Major depressive disorder	1	["DFFA"]
Alzheimer disease	1	["CASP3"]
Brain ischemia	1	["CASP3"]
Calcinosis	1	["CASP3"]
Cerebral hemorrhage	1	["CASP3"]