COX6B2 (cytochrome c oxidase subunit 6B2)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 125965
• Gene name: Cytochrome c oxidase subunit 6B2
• Gene symbol: COX6B2
• Synonyms (NCBI Gene): COXVIB2, CT59
• Chromosome: 19
• Chromosome location: 19q13.42

miRNA Show/Hide all (212)

miRTarBase ID	miRNA	Experiments	Reference
MIRT905456	hsa-miR-1285	CLIP-seq
MIRT905457	hsa-miR-149	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT905459	hsa-miR-1909	CLIP-seq
MIRT905460	hsa-miR-2467-3p	CLIP-seq
MIRT905461	hsa-miR-2861	CLIP-seq
MIRT905462	hsa-miR-3064-5p	CLIP-seq
MIRT905463	hsa-miR-3122	CLIP-seq
MIRT905464	hsa-miR-3160-3p	CLIP-seq
MIRT905465	hsa-miR-3165	CLIP-seq
MIRT905466	hsa-miR-3187-5p	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT905470	hsa-miR-3689a-3p	CLIP-seq
MIRT905471	hsa-miR-3689c	CLIP-seq
MIRT905472	hsa-miR-3913-5p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905474	hsa-miR-4257	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905476	hsa-miR-4456	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905478	hsa-miR-4487	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905481	hsa-miR-4728-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905483	hsa-miR-4793-5p	CLIP-seq
MIRT905484	hsa-miR-4794	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905486	hsa-miR-541	CLIP-seq
MIRT905487	hsa-miR-558	CLIP-seq
MIRT905488	hsa-miR-612	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT905490	hsa-miR-654-5p	CLIP-seq
MIRT905491	hsa-miR-661	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT1547447	hsa-miR-542-3p	CLIP-seq
MIRT1968502	hsa-miR-1268	CLIP-seq
MIRT1968503	hsa-miR-1268b	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT905460	hsa-miR-2467-3p	CLIP-seq
MIRT905463	hsa-miR-3122	CLIP-seq
MIRT905464	hsa-miR-3160-3p	CLIP-seq
MIRT1968504	hsa-miR-320e	CLIP-seq
MIRT1968505	hsa-miR-323-5p	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT905470	hsa-miR-3689a-3p	CLIP-seq
MIRT905471	hsa-miR-3689c	CLIP-seq
MIRT905472	hsa-miR-3913-5p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905474	hsa-miR-4257	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT1968506	hsa-miR-4486	CLIP-seq
MIRT905478	hsa-miR-4487	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT1968507	hsa-miR-4684-5p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905481	hsa-miR-4728-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905486	hsa-miR-541	CLIP-seq
MIRT1968508	hsa-miR-548c-3p	CLIP-seq
MIRT905487	hsa-miR-558	CLIP-seq
MIRT1968509	hsa-miR-585	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT905490	hsa-miR-654-5p	CLIP-seq
MIRT1968510	hsa-miR-876-3p	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT2204387	hsa-miR-24	CLIP-seq
MIRT905460	hsa-miR-2467-3p	CLIP-seq
MIRT905463	hsa-miR-3122	CLIP-seq
MIRT905464	hsa-miR-3160-3p	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT905470	hsa-miR-3689a-3p	CLIP-seq
MIRT905471	hsa-miR-3689c	CLIP-seq
MIRT905472	hsa-miR-3913-5p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905474	hsa-miR-4257	CLIP-seq
MIRT2204388	hsa-miR-4284	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905478	hsa-miR-4487	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905481	hsa-miR-4728-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905486	hsa-miR-541	CLIP-seq
MIRT905487	hsa-miR-558	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT905490	hsa-miR-654-5p	CLIP-seq
MIRT905491	hsa-miR-661	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT905463	hsa-miR-3122	CLIP-seq
MIRT905470	hsa-miR-3689a-3p	CLIP-seq
MIRT905471	hsa-miR-3689c	CLIP-seq
MIRT905472	hsa-miR-3913-5p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905481	hsa-miR-4728-5p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905486	hsa-miR-541	CLIP-seq
MIRT905490	hsa-miR-654-5p	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT2447499	hsa-miR-1205	CLIP-seq
MIRT2447500	hsa-miR-1207-3p	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT905459	hsa-miR-1909	CLIP-seq
MIRT905460	hsa-miR-2467-3p	CLIP-seq
MIRT2447501	hsa-miR-3144-5p	CLIP-seq
MIRT2447502	hsa-miR-3200-3p	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT2447503	hsa-miR-3925-3p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905474	hsa-miR-4257	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT2447504	hsa-miR-766	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT905460	hsa-miR-2467-3p	CLIP-seq
MIRT2507891	hsa-miR-3120-5p	CLIP-seq
MIRT905463	hsa-miR-3122	CLIP-seq
MIRT905464	hsa-miR-3160-3p	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT2507892	hsa-miR-3613-3p	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT2507893	hsa-miR-3664-5p	CLIP-seq
MIRT905470	hsa-miR-3689a-3p	CLIP-seq
MIRT905471	hsa-miR-3689c	CLIP-seq
MIRT2507894	hsa-miR-371-5p	CLIP-seq
MIRT2507895	hsa-miR-371b-5p	CLIP-seq
MIRT905472	hsa-miR-3913-5p	CLIP-seq
MIRT2447503	hsa-miR-3925-3p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905474	hsa-miR-4257	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905478	hsa-miR-4487	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905481	hsa-miR-4728-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905486	hsa-miR-541	CLIP-seq
MIRT2507896	hsa-miR-544b	CLIP-seq
MIRT1968508	hsa-miR-548c-3p	CLIP-seq
MIRT905487	hsa-miR-558	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT905490	hsa-miR-654-5p	CLIP-seq
MIRT2447504	hsa-miR-766	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq
MIRT905458	hsa-miR-1827	CLIP-seq
MIRT905460	hsa-miR-2467-3p	CLIP-seq
MIRT2507891	hsa-miR-3120-5p	CLIP-seq
MIRT905463	hsa-miR-3122	CLIP-seq
MIRT905464	hsa-miR-3160-3p	CLIP-seq
MIRT905467	hsa-miR-34b	CLIP-seq
MIRT905468	hsa-miR-3612	CLIP-seq
MIRT2507892	hsa-miR-3613-3p	CLIP-seq
MIRT905469	hsa-miR-3614-5p	CLIP-seq
MIRT2507893	hsa-miR-3664-5p	CLIP-seq
MIRT905470	hsa-miR-3689a-3p	CLIP-seq
MIRT905471	hsa-miR-3689c	CLIP-seq
MIRT2507894	hsa-miR-371-5p	CLIP-seq
MIRT2507895	hsa-miR-371b-5p	CLIP-seq
MIRT905472	hsa-miR-3913-5p	CLIP-seq
MIRT905473	hsa-miR-3929	CLIP-seq
MIRT905474	hsa-miR-4257	CLIP-seq
MIRT905475	hsa-miR-4419b	CLIP-seq
MIRT905477	hsa-miR-4478	CLIP-seq
MIRT905478	hsa-miR-4487	CLIP-seq
MIRT905479	hsa-miR-4649-3p	CLIP-seq
MIRT905480	hsa-miR-4722-5p	CLIP-seq
MIRT905481	hsa-miR-4728-5p	CLIP-seq
MIRT905482	hsa-miR-4768-3p	CLIP-seq
MIRT905485	hsa-miR-485-5p	CLIP-seq
MIRT905486	hsa-miR-541	CLIP-seq
MIRT1968508	hsa-miR-548c-3p	CLIP-seq
MIRT905487	hsa-miR-558	CLIP-seq
MIRT905489	hsa-miR-650	CLIP-seq
MIRT905490	hsa-miR-654-5p	CLIP-seq
MIRT905492	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006119	Process	Oxidative phosphorylation	IEA
GO:0016020	Component	Membrane	IEA
GO:0030061	Component	Mitochondrial crista	IBA
GO:0030061	Component	Mitochondrial crista	IDA	12874793
GO:0045277	Component	Respiratory chain complex IV	IEA

Other IDs

• MIM: 618127
• HGNC: 24380
• e!Ensembl: ENSG00000160471

Protein

• UniProt ID: Q6YFQ2
• Protein name: Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)
• Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02297	COX6B	21 → 85	Cytochrome oxidase c subunit VIb	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines. {ECO:0000269|PubMed:12874793, ECO:0000269|PubMed:15905330}.
• Sequence:

  MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYF
  RVYHSLCPISWVESWNEQIKNGIFAGKI

• Sequence length: 88

Pathways

KEGG Pathway

Oxidative phosphorylation

Metabolic pathways

Cardiac muscle contraction

Thermogenesis

Non-alcoholic fatty liver disease

Alzheimer disease

Parkinson disease

Amyotrophic lateral sclerosis

Huntington disease

Prion disease

Pathways of neurodegeneration - multiple diseases

Chemical carcinogenesis - reactive oxygen species

Diabetic cardiomyopathy

Related Genes

Sort by: Blended Diseases Pathways Evidence source

COX6A2 8 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy Related via 8 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX7A1 8 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy Related via 8 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX7A2 8 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy Related via 8 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX7B2 8 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy Related via 8 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction. COX8C 8 shared pathwaysOxidative phosphorylation, Cardiac muscle contraction, Thermogenesis, Non-alcoholic fatty liver disease, Parkinson disease, Prion disease, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy Related via 8 shared pathways including Oxidative phosphorylation, Cardiac muscle contraction.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
COX6A2	0	[]	8	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	0	[]
COX7A1	0	[]	8	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	0	[]
COX7A2	0	[]	8	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	0	[]
COX7B2	0	[]	8	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	0	[]
COX8C	0	[]	8	["Oxidative phosphorylation","Cardiac muscle contraction","Thermogenesis","Non-alcoholic fatty liver disease","Parkinson disease","Prion disease","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	0	[]

Diseases Linked via Similar Genes

Cytochrome c oxidase deficiency Linked via 1 of 5 related genesCOX6A2 Mitochondrial complex deficiency Linked via 1 of 5 related genesCOX6A2 Mitochondrial disease Linked via 1 of 5 related genesCOX6A2 Asthma Linked via 1 of 5 related genesCOX7A2 Alzheimer disease Linked via 1 of 5 related genesCOX7B2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Cytochrome c oxidase deficiency	1	["COX6A2"]
Mitochondrial complex deficiency	1	["COX6A2"]
Mitochondrial disease	1	["COX6A2"]
Asthma	1	["COX7A2"]
Alzheimer disease	1	["COX7B2"]