Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9074
Gene name	Claudin 6
Gene symbol	CLDN6
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16p13.3
Summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space.

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miRTarBase ID	miRNA	Experiments
MIRT895498	hsa-miR-15a	CLIP-seq
MIRT895499	hsa-miR-15b	CLIP-seq
MIRT895500	hsa-miR-16	CLIP-seq
MIRT895501	hsa-miR-1825	CLIP-seq
MIRT895502	hsa-miR-1910	CLIP-seq
MIRT895503	hsa-miR-195	CLIP-seq
MIRT895504	hsa-miR-198	CLIP-seq
MIRT895505	hsa-miR-199a-5p	CLIP-seq
MIRT895506	hsa-miR-199b-5p	CLIP-seq
MIRT895507	hsa-miR-2053	CLIP-seq
MIRT895508	hsa-miR-214	CLIP-seq
MIRT895509	hsa-miR-3121-5p	CLIP-seq
MIRT895510	hsa-miR-361-3p	CLIP-seq
MIRT895511	hsa-miR-3619-5p	CLIP-seq
MIRT895512	hsa-miR-3913-3p	CLIP-seq
MIRT895513	hsa-miR-3943	CLIP-seq
MIRT895514	hsa-miR-424	CLIP-seq
MIRT895515	hsa-miR-4530	CLIP-seq
MIRT895516	hsa-miR-4680-5p	CLIP-seq
MIRT895517	hsa-miR-489	CLIP-seq
MIRT895518	hsa-miR-497	CLIP-seq
MIRT895519	hsa-miR-541	CLIP-seq
MIRT895520	hsa-miR-654-5p	CLIP-seq
MIRT895521	hsa-miR-761	CLIP-seq
MIRT895522	hsa-miR-873	CLIP-seq
MIRT895498	hsa-miR-15a	CLIP-seq
MIRT895499	hsa-miR-15b	CLIP-seq
MIRT895500	hsa-miR-16	CLIP-seq
MIRT895503	hsa-miR-195	CLIP-seq
MIRT895508	hsa-miR-214	CLIP-seq
MIRT895510	hsa-miR-361-3p	CLIP-seq
MIRT895511	hsa-miR-3619-5p	CLIP-seq
MIRT895513	hsa-miR-3943	CLIP-seq
MIRT895514	hsa-miR-424	CLIP-seq
MIRT895515	hsa-miR-4530	CLIP-seq
MIRT895516	hsa-miR-4680-5p	CLIP-seq
MIRT895518	hsa-miR-497	CLIP-seq
MIRT895521	hsa-miR-761	CLIP-seq
MIRT895522	hsa-miR-873	CLIP-seq
MIRT2386153	hsa-miR-3120-3p	CLIP-seq
MIRT2386153	hsa-miR-3120-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0001618	Function	Virus receptor activity	IMP	20375010
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	20375010, 32296183, 36935496
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20375010
GO:0005886	Component	Plasma membrane	IEA
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005923	Component	Bicellular tight junction	ISS
GO:0007155	Process	Cell adhesion	IBA
GO:0016020	Component	Membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016338	Process	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS
GO:0042802	Function	Identical protein binding	ISS
GO:0045216	Process	Cell-cell junction organization	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0070830	Process	Bicellular tight junction assembly	IBA

MIM	HGNC	e!Ensembl
615798	2048	ENSG00000184697

P56747

Protein name

Claudin-6 (Skullin)

Protein function

Plays a major role in tight junction-specific obliteration of the intercellular space. ; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. {ECO:0000269|PubMed:17804490, ECO:000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00822	PMP22_Claudin	4 → 181	PMP-22/EMP/MP20/Claudin family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. {ECO:0000269|PubMed:17804490}.

Sequence

MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG
QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT
SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL
LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV

Sequence length

220

Interactions

View interactions

KEGG Pathway
Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C

CLDN6 (claudin 6)

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