CLDN25 (claudin 25)

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Gene Gene information from NCBI Gene database.
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Entrez ID 644672
Gene name Claudin 25
Gene symbol CLDN25
Synonyms (NCBI Gene)
-
Chromosome 11
Chromosome location 11q23.2
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellula
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005198 Function Structural molecule activity IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005923 Component Bicellular tight junction IBA
GO:0005923 Component Bicellular tight junction IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
620812 37218 ENSG00000228607
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
C9JDP6
Protein name Claudin-25
Protein function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00822 PMP22_Claudin 7 → 183 PMP-22/EMP/MP20/Claudin family Family
Sequence 
MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEMETWIMGIWEVCVDREEV
ATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGL
LGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGG
LLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSFHLMLRPRNLVI
Sequence length 229
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway
Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C
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CLDN24 6 shared pathwaysVirion - Hepatitis viruses, Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C Related via 6 shared pathways including Virion - Hepatitis viruses, Cell adhesion molecules. CLDN34 6 shared pathwaysVirion - Hepatitis viruses, Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C Related via 6 shared pathways including Virion - Hepatitis viruses, Cell adhesion molecules. CLDN16 6 shared pathwaysVirion - Hepatitis viruses, Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C Related via 6 shared pathways including Virion - Hepatitis viruses, Cell adhesion molecules. CLDN4 6 shared pathwaysVirion - Hepatitis viruses, Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C Related via 6 shared pathways including Virion - Hepatitis viruses, Cell adhesion molecules. CLDN3 6 shared pathwaysVirion - Hepatitis viruses, Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C Related via 6 shared pathways including Virion - Hepatitis viruses, Cell adhesion molecules.
Polycystic ovary syndrome Linked via 2 of 5 related genesCLDN16, CLDN4 Jeune syndrome Linked via 1 of 5 related genesCLDN24 Major depressive disorder Linked via 1 of 5 related genesCLDN24 Gout Linked via 1 of 5 related genesCLDN24 Stroke Linked via 1 of 5 related genesCLDN24