CHTOP (chromatin target of PRMT1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26097
• Gene name: Chromatin target of PRMT1
• Gene symbol: CHTOP
• Synonyms (NCBI Gene): C10orf77, C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent

miRNA Show/Hide all (253)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020760	hsa-miR-155-5p	Proteomics	18668040
MIRT049707	hsa-miR-92a-3p	CLASH	23622248
MIRT048090	hsa-miR-197-3p	CLASH	23622248
MIRT045224	hsa-miR-186-5p	CLASH	23622248
MIRT041594	hsa-miR-193b-3p	CLASH	23622248
MIRT038414	hsa-miR-296-3p	CLASH	23622248
MIRT333285	hsa-miR-5700	HITS-CLIP	23313552
MIRT704676	hsa-miR-449b-3p	HITS-CLIP	23313552
MIRT704675	hsa-miR-4476	HITS-CLIP	23313552
MIRT704674	hsa-miR-6876-5p	HITS-CLIP	23313552
MIRT333277	hsa-miR-586	HITS-CLIP	23313552
MIRT704673	hsa-miR-4457	HITS-CLIP	23313552
MIRT266632	hsa-miR-4257	HITS-CLIP	23313552
MIRT266638	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT266622	hsa-let-7a-5p	HITS-CLIP	23313552
MIRT266623	hsa-let-7b-5p	HITS-CLIP	23313552
MIRT266624	hsa-let-7c-5p	HITS-CLIP	23313552
MIRT266625	hsa-let-7d-5p	HITS-CLIP	23313552
MIRT266626	hsa-let-7e-5p	HITS-CLIP	23313552
MIRT266627	hsa-let-7f-5p	HITS-CLIP	23313552
MIRT266629	hsa-let-7g-5p	HITS-CLIP	23313552
MIRT266630	hsa-let-7i-5p	HITS-CLIP	23313552
MIRT266634	hsa-miR-4458	HITS-CLIP	23313552
MIRT266635	hsa-miR-4500	HITS-CLIP	23313552
MIRT266628	hsa-miR-98-5p	HITS-CLIP	23313552
MIRT266636	hsa-miR-6077	HITS-CLIP	23313552
MIRT266631	hsa-miR-609	HITS-CLIP	23313552
MIRT266641	hsa-miR-8065	HITS-CLIP	23313552
MIRT704672	hsa-miR-1287-3p	HITS-CLIP	23313552
MIRT333285	hsa-miR-5700	HITS-CLIP	23313552
MIRT704676	hsa-miR-449b-3p	HITS-CLIP	23313552
MIRT704675	hsa-miR-4476	HITS-CLIP	23313552
MIRT704674	hsa-miR-6876-5p	HITS-CLIP	23313552
MIRT333277	hsa-miR-586	HITS-CLIP	23313552
MIRT704673	hsa-miR-4457	HITS-CLIP	23313552
MIRT266632	hsa-miR-4257	HITS-CLIP	23313552
MIRT266638	hsa-miR-6804-5p	HITS-CLIP	23313552
MIRT266622	hsa-let-7a-5p	HITS-CLIP	23313552
MIRT266623	hsa-let-7b-5p	HITS-CLIP	23313552
MIRT266624	hsa-let-7c-5p	HITS-CLIP	23313552
MIRT266625	hsa-let-7d-5p	HITS-CLIP	23313552
MIRT266626	hsa-let-7e-5p	HITS-CLIP	23313552
MIRT266627	hsa-let-7f-5p	HITS-CLIP	23313552
MIRT266629	hsa-let-7g-5p	HITS-CLIP	23313552
MIRT266630	hsa-let-7i-5p	HITS-CLIP	23313552
MIRT266634	hsa-miR-4458	HITS-CLIP	23313552
MIRT266635	hsa-miR-4500	HITS-CLIP	23313552
MIRT266628	hsa-miR-98-5p	HITS-CLIP	23313552
MIRT266636	hsa-miR-6077	HITS-CLIP	23313552
MIRT266631	hsa-miR-609	HITS-CLIP	23313552
MIRT266641	hsa-miR-8065	HITS-CLIP	23313552
MIRT704672	hsa-miR-1287-3p	HITS-CLIP	23313552
MIRT892835	hsa-let-7a	CLIP-seq
MIRT892836	hsa-let-7b	CLIP-seq
MIRT892837	hsa-let-7c	CLIP-seq
MIRT892838	hsa-let-7d	CLIP-seq
MIRT892839	hsa-let-7e	CLIP-seq
MIRT892840	hsa-let-7f	CLIP-seq
MIRT892841	hsa-let-7g	CLIP-seq
MIRT892842	hsa-let-7i	CLIP-seq
MIRT892843	hsa-miR-106a	CLIP-seq
MIRT892844	hsa-miR-106b	CLIP-seq
MIRT892845	hsa-miR-1185	CLIP-seq
MIRT892846	hsa-miR-1252	CLIP-seq
MIRT892847	hsa-miR-130a	CLIP-seq
MIRT892848	hsa-miR-130b	CLIP-seq
MIRT892849	hsa-miR-1321	CLIP-seq
MIRT892850	hsa-miR-138	CLIP-seq
MIRT892851	hsa-miR-141	CLIP-seq
MIRT892852	hsa-miR-154	CLIP-seq
MIRT892853	hsa-miR-17	CLIP-seq
MIRT892854	hsa-miR-200a	CLIP-seq
MIRT892855	hsa-miR-20a	CLIP-seq
MIRT892856	hsa-miR-20b	CLIP-seq
MIRT892857	hsa-miR-216a	CLIP-seq
MIRT892858	hsa-miR-301a	CLIP-seq
MIRT892859	hsa-miR-301b	CLIP-seq
MIRT892860	hsa-miR-302f	CLIP-seq
MIRT892861	hsa-miR-31	CLIP-seq
MIRT892862	hsa-miR-3122	CLIP-seq
MIRT892863	hsa-miR-3175	CLIP-seq
MIRT892864	hsa-miR-3184	CLIP-seq
MIRT892865	hsa-miR-320e	CLIP-seq
MIRT892866	hsa-miR-33a	CLIP-seq
MIRT892867	hsa-miR-33b	CLIP-seq
MIRT892868	hsa-miR-3605-5p	CLIP-seq
MIRT892869	hsa-miR-3666	CLIP-seq
MIRT892870	hsa-miR-3679-5p	CLIP-seq
MIRT892871	hsa-miR-3688-5p	CLIP-seq
MIRT892872	hsa-miR-3913-5p	CLIP-seq
MIRT892873	hsa-miR-3927	CLIP-seq
MIRT892874	hsa-miR-423-5p	CLIP-seq
MIRT892875	hsa-miR-4270	CLIP-seq
MIRT892876	hsa-miR-4272	CLIP-seq
MIRT892877	hsa-miR-4295	CLIP-seq
MIRT892878	hsa-miR-4441	CLIP-seq
MIRT892879	hsa-miR-4456	CLIP-seq
MIRT892880	hsa-miR-450b-3p	CLIP-seq
MIRT892881	hsa-miR-4521	CLIP-seq
MIRT892882	hsa-miR-4533	CLIP-seq
MIRT892883	hsa-miR-454	CLIP-seq
MIRT892884	hsa-miR-455-5p	CLIP-seq
MIRT892885	hsa-miR-4650-3p	CLIP-seq
MIRT892886	hsa-miR-4699-3p	CLIP-seq
MIRT892887	hsa-miR-4739	CLIP-seq
MIRT892888	hsa-miR-4756-5p	CLIP-seq
MIRT892889	hsa-miR-4761-5p	CLIP-seq
MIRT892890	hsa-miR-4772-5p	CLIP-seq
MIRT892891	hsa-miR-485-3p	CLIP-seq
MIRT892892	hsa-miR-513c	CLIP-seq
MIRT892893	hsa-miR-514b-5p	CLIP-seq
MIRT892894	hsa-miR-519a	CLIP-seq
MIRT892895	hsa-miR-519b-3p	CLIP-seq
MIRT892896	hsa-miR-519c-3p	CLIP-seq
MIRT892897	hsa-miR-519d	CLIP-seq
MIRT892898	hsa-miR-520d-5p	CLIP-seq
MIRT892899	hsa-miR-524-5p	CLIP-seq
MIRT892900	hsa-miR-548a-5p	CLIP-seq
MIRT892901	hsa-miR-548ab	CLIP-seq
MIRT892902	hsa-miR-548ak	CLIP-seq
MIRT892903	hsa-miR-548b-5p	CLIP-seq
MIRT892904	hsa-miR-548c-5p	CLIP-seq
MIRT892905	hsa-miR-548d-5p	CLIP-seq
MIRT892906	hsa-miR-548h	CLIP-seq
MIRT892907	hsa-miR-548i	CLIP-seq
MIRT892908	hsa-miR-548j	CLIP-seq
MIRT892909	hsa-miR-548m	CLIP-seq
MIRT892910	hsa-miR-548n	CLIP-seq
MIRT892911	hsa-miR-548w	CLIP-seq
MIRT892912	hsa-miR-548y	CLIP-seq
MIRT892913	hsa-miR-559	CLIP-seq
MIRT892914	hsa-miR-576-3p	CLIP-seq
MIRT892915	hsa-miR-584	CLIP-seq
MIRT892916	hsa-miR-603	CLIP-seq
MIRT892917	hsa-miR-769-3p	CLIP-seq
MIRT892918	hsa-miR-93	CLIP-seq
MIRT892919	hsa-miR-98	CLIP-seq
MIRT892868	hsa-miR-3605-5p	CLIP-seq
MIRT892920	hsa-miR-3689a-3p	CLIP-seq
MIRT892921	hsa-miR-3689c	CLIP-seq
MIRT892922	hsa-miR-4728-5p	CLIP-seq
MIRT1964628	hsa-miR-105	CLIP-seq
MIRT1964629	hsa-miR-1228	CLIP-seq
MIRT1964630	hsa-miR-135a	CLIP-seq
MIRT1964631	hsa-miR-135b	CLIP-seq
MIRT892852	hsa-miR-154	CLIP-seq
MIRT1964632	hsa-miR-25	CLIP-seq
MIRT1964633	hsa-miR-3192	CLIP-seq
MIRT1964634	hsa-miR-32	CLIP-seq
MIRT1964635	hsa-miR-329	CLIP-seq
MIRT1964636	hsa-miR-338-3p	CLIP-seq
MIRT1964637	hsa-miR-362-3p	CLIP-seq
MIRT1964638	hsa-miR-363	CLIP-seq
MIRT1964639	hsa-miR-367	CLIP-seq
MIRT1964640	hsa-miR-3670	CLIP-seq
MIRT1964641	hsa-miR-3912	CLIP-seq
MIRT1964642	hsa-miR-4261	CLIP-seq
MIRT1964643	hsa-miR-4311	CLIP-seq
MIRT1964644	hsa-miR-4314	CLIP-seq
MIRT1964645	hsa-miR-4530	CLIP-seq
MIRT1964646	hsa-miR-4646-5p	CLIP-seq
MIRT1964647	hsa-miR-4652-3p	CLIP-seq
MIRT1964648	hsa-miR-4659a-3p	CLIP-seq
MIRT1964649	hsa-miR-4659b-3p	CLIP-seq
MIRT892886	hsa-miR-4699-3p	CLIP-seq
MIRT1964650	hsa-miR-4705	CLIP-seq
MIRT1964651	hsa-miR-4724-5p	CLIP-seq
MIRT1964652	hsa-miR-4738-3p	CLIP-seq
MIRT892889	hsa-miR-4761-5p	CLIP-seq
MIRT1964653	hsa-miR-4762-3p	CLIP-seq
MIRT1964654	hsa-miR-4799-5p	CLIP-seq
MIRT892892	hsa-miR-513c	CLIP-seq
MIRT892893	hsa-miR-514b-5p	CLIP-seq
MIRT892914	hsa-miR-576-3p	CLIP-seq
MIRT1964655	hsa-miR-599	CLIP-seq
MIRT1964656	hsa-miR-642b	CLIP-seq
MIRT1964657	hsa-miR-92a	CLIP-seq
MIRT1964658	hsa-miR-92b	CLIP-seq
MIRT1964659	hsa-miR-942	CLIP-seq
MIRT1964628	hsa-miR-105	CLIP-seq
MIRT1964629	hsa-miR-1228	CLIP-seq
MIRT1964630	hsa-miR-135a	CLIP-seq
MIRT1964631	hsa-miR-135b	CLIP-seq
MIRT1964632	hsa-miR-25	CLIP-seq
MIRT1964634	hsa-miR-32	CLIP-seq
MIRT1964635	hsa-miR-329	CLIP-seq
MIRT1964637	hsa-miR-362-3p	CLIP-seq
MIRT1964638	hsa-miR-363	CLIP-seq
MIRT1964639	hsa-miR-367	CLIP-seq
MIRT1964653	hsa-miR-4762-3p	CLIP-seq
MIRT1964656	hsa-miR-642b	CLIP-seq
MIRT1964657	hsa-miR-92a	CLIP-seq
MIRT1964658	hsa-miR-92b	CLIP-seq
MIRT892891	hsa-miR-485-3p	CLIP-seq
MIRT1964628	hsa-miR-105	CLIP-seq
MIRT1964629	hsa-miR-1228	CLIP-seq
MIRT1964630	hsa-miR-135a	CLIP-seq
MIRT1964631	hsa-miR-135b	CLIP-seq
MIRT1964635	hsa-miR-329	CLIP-seq
MIRT1964637	hsa-miR-362-3p	CLIP-seq
MIRT1964653	hsa-miR-4762-3p	CLIP-seq
MIRT1964656	hsa-miR-642b	CLIP-seq
MIRT1964628	hsa-miR-105	CLIP-seq
MIRT1964629	hsa-miR-1228	CLIP-seq
MIRT1964630	hsa-miR-135a	CLIP-seq
MIRT1964631	hsa-miR-135b	CLIP-seq
MIRT1964632	hsa-miR-25	CLIP-seq
MIRT2503484	hsa-miR-3148	CLIP-seq
MIRT1964634	hsa-miR-32	CLIP-seq
MIRT1964635	hsa-miR-329	CLIP-seq
MIRT2503485	hsa-miR-3545-3p	CLIP-seq
MIRT1964637	hsa-miR-362-3p	CLIP-seq
MIRT1964638	hsa-miR-363	CLIP-seq
MIRT2503486	hsa-miR-3663-5p	CLIP-seq
MIRT1964639	hsa-miR-367	CLIP-seq
MIRT1964642	hsa-miR-4261	CLIP-seq
MIRT2503487	hsa-miR-433	CLIP-seq
MIRT2503488	hsa-miR-4481	CLIP-seq
MIRT1964651	hsa-miR-4724-5p	CLIP-seq
MIRT1964652	hsa-miR-4738-3p	CLIP-seq
MIRT2503489	hsa-miR-4745-5p	CLIP-seq
MIRT2503490	hsa-miR-4758-5p	CLIP-seq
MIRT1964653	hsa-miR-4762-3p	CLIP-seq
MIRT2503491	hsa-miR-563	CLIP-seq
MIRT892915	hsa-miR-584	CLIP-seq
MIRT1964656	hsa-miR-642b	CLIP-seq
MIRT1964657	hsa-miR-92a	CLIP-seq
MIRT1964658	hsa-miR-92b	CLIP-seq
MIRT1964628	hsa-miR-105	CLIP-seq
MIRT1964629	hsa-miR-1228	CLIP-seq
MIRT1964630	hsa-miR-135a	CLIP-seq
MIRT1964631	hsa-miR-135b	CLIP-seq
MIRT1964632	hsa-miR-25	CLIP-seq
MIRT2503484	hsa-miR-3148	CLIP-seq
MIRT1964634	hsa-miR-32	CLIP-seq
MIRT1964635	hsa-miR-329	CLIP-seq
MIRT2503485	hsa-miR-3545-3p	CLIP-seq
MIRT1964637	hsa-miR-362-3p	CLIP-seq
MIRT1964638	hsa-miR-363	CLIP-seq
MIRT2503486	hsa-miR-3663-5p	CLIP-seq
MIRT1964639	hsa-miR-367	CLIP-seq
MIRT1964642	hsa-miR-4261	CLIP-seq
MIRT2503488	hsa-miR-4481	CLIP-seq
MIRT1964651	hsa-miR-4724-5p	CLIP-seq
MIRT1964652	hsa-miR-4738-3p	CLIP-seq
MIRT2503489	hsa-miR-4745-5p	CLIP-seq
MIRT2503490	hsa-miR-4758-5p	CLIP-seq
MIRT1964653	hsa-miR-4762-3p	CLIP-seq
MIRT2503491	hsa-miR-563	CLIP-seq
MIRT892915	hsa-miR-584	CLIP-seq
MIRT1964656	hsa-miR-642b	CLIP-seq
MIRT1964657	hsa-miR-92a	CLIP-seq
MIRT1964658	hsa-miR-92b	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000346	Component	Transcription export complex	IDA	23299939
GO:0001701	Process	In utero embryonic development	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	14667819, 19858291, 23299939, 23602568, 25284789, 25416956, 30021884, 32296183, 32707033, 33961781, 37020021
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006338	Process	Chromatin remodeling	IMP	25284789
GO:0006406	Process	MRNA export from nucleus	IDA	23299939
GO:0008327	Function	Methyl-CpG binding	IBA
GO:0008327	Function	Methyl-CpG binding	IDA	25284789
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA	23299939
GO:0016607	Component	Nuclear speck	IEA
GO:0032781	Process	Positive regulation of ATP-dependent activity	IDA	23299939
GO:0051028	Process	MRNA transport	IEA
GO:0051096	Process	Positive regulation of helicase activity	IDA	23299939

Other IDs

• MIM: 614206
• HGNC: 24511
• e!Ensembl: ENSG00000160679

Protein

• UniProt ID: Q9Y3Y2
• Protein name: Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)
• Protein function: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylati
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13865	FoP_duplication	165 → 243	C-terminal duplication domain of Friend of PRMT1	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789). {ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.
• Sequence:

  MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPTPVNIRASMQQQQQLASARNRRLAQQME
  NRPSVQAALKLKQSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGG
  RATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGR
  GRGMIGRGRGGFGGRGRGRGRGRGALARPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMA
  QTDPETND

• Sequence length: 248

Pathways

Reactome Pathway

Transport of Mature mRNA derived from an Intron-Containing Transcript

mRNA 3'-end processing

RNA Polymerase II Transcription Termination

Related Genes

Sort by: Blended Diseases Pathways Evidence source

DDX39A 3 shared pathwaysTransport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, RNA Polymerase II Transcription Termination Related via 3 shared pathways including Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing. LUZP4 3 shared pathwaysTransport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, RNA Polymerase II Transcription Termination Related via 3 shared pathways including Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing. FYTTD1 3 shared pathwaysTransport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, RNA Polymerase II Transcription Termination Related via 3 shared pathways including Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing. POLDIP3 3 shared pathwaysTransport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, RNA Polymerase II Transcription Termination Related via 3 shared pathways including Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing. SARNP 3 shared pathwaysTransport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, RNA Polymerase II Transcription Termination Related via 3 shared pathways including Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
DDX39A	0	[]	3	["Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	0	[]
LUZP4	0	[]	3	["Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	0	[]
FYTTD1	0	[]	3	["Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	0	[]
POLDIP3	0	[]	3	["Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	0	[]
SARNP	0	[]	3	["Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	0	[]

Diseases Linked via Similar Genes

Kawasaki disease Linked via 1 of 5 related genesSARNP

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Kawasaki disease	1	["SARNP"]