Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	56548
Gene name	Carbohydrate sulfotransferase 7
Gene symbol	CHST7
Synonyms (NCBI Gene)	C6ST-2GST-5
Chromosome	X
Chromosome location	Xp11.3
Summary	This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and am

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029511	hsa-miR-26b-5p	Microarray	19088304
MIRT892598	hsa-miR-1185	CLIP-seq
MIRT892599	hsa-miR-127-3p	CLIP-seq
MIRT892600	hsa-miR-1294	CLIP-seq
MIRT892601	hsa-miR-134	CLIP-seq
MIRT892602	hsa-miR-1915	CLIP-seq
MIRT892603	hsa-miR-1973	CLIP-seq
MIRT892604	hsa-miR-203	CLIP-seq
MIRT892605	hsa-miR-214	CLIP-seq
MIRT892606	hsa-miR-25	CLIP-seq
MIRT892607	hsa-miR-2964a-3p	CLIP-seq
MIRT892608	hsa-miR-3118	CLIP-seq
MIRT892609	hsa-miR-3136-5p	CLIP-seq
MIRT892610	hsa-miR-32	CLIP-seq
MIRT892611	hsa-miR-337-3p	CLIP-seq
MIRT892612	hsa-miR-3605-5p	CLIP-seq
MIRT892613	hsa-miR-3619-5p	CLIP-seq
MIRT892614	hsa-miR-363	CLIP-seq
MIRT892615	hsa-miR-367	CLIP-seq
MIRT892616	hsa-miR-3677-3p	CLIP-seq
MIRT892617	hsa-miR-3679-5p	CLIP-seq
MIRT892618	hsa-miR-4270	CLIP-seq
MIRT892619	hsa-miR-4291	CLIP-seq
MIRT892620	hsa-miR-4312	CLIP-seq
MIRT892621	hsa-miR-4316	CLIP-seq
MIRT892622	hsa-miR-4439	CLIP-seq
MIRT892623	hsa-miR-4441	CLIP-seq
MIRT892624	hsa-miR-4446-5p	CLIP-seq
MIRT892625	hsa-miR-4513	CLIP-seq
MIRT892626	hsa-miR-4690-3p	CLIP-seq
MIRT892627	hsa-miR-532-5p	CLIP-seq
MIRT892628	hsa-miR-653	CLIP-seq
MIRT892629	hsa-miR-761	CLIP-seq
MIRT892630	hsa-miR-767-3p	CLIP-seq
MIRT892631	hsa-miR-922	CLIP-seq
MIRT892632	hsa-miR-92a	CLIP-seq
MIRT892633	hsa-miR-92b	CLIP-seq
MIRT2200719	hsa-miR-1825	CLIP-seq
MIRT2200720	hsa-miR-199a-5p	CLIP-seq
MIRT2200721	hsa-miR-199b-5p	CLIP-seq
MIRT2200722	hsa-miR-3925-3p	CLIP-seq
MIRT2200723	hsa-miR-512-3p	CLIP-seq
MIRT2200724	hsa-miR-515-5p	CLIP-seq
MIRT2200725	hsa-miR-766	CLIP-seq
MIRT2447058	hsa-miR-3682-5p	CLIP-seq
MIRT2447059	hsa-miR-4277	CLIP-seq
MIRT2447060	hsa-miR-548c-3p	CLIP-seq
MIRT2447058	hsa-miR-3682-5p	CLIP-seq
MIRT2447059	hsa-miR-4277	CLIP-seq
MIRT2447060	hsa-miR-548c-3p	CLIP-seq
MIRT2503425	hsa-miR-1243	CLIP-seq
MIRT2503426	hsa-miR-3654	CLIP-seq
MIRT2503427	hsa-miR-4261	CLIP-seq
MIRT2503428	hsa-miR-4528	CLIP-seq
MIRT2503429	hsa-miR-668	CLIP-seq
MIRT2503430	hsa-miR-875-3p	CLIP-seq
MIRT2503425	hsa-miR-1243	CLIP-seq
MIRT892605	hsa-miR-214	CLIP-seq
MIRT892606	hsa-miR-25	CLIP-seq
MIRT892607	hsa-miR-2964a-3p	CLIP-seq
MIRT2678197	hsa-miR-3074-5p	CLIP-seq
MIRT2678198	hsa-miR-3145-3p	CLIP-seq
MIRT892610	hsa-miR-32	CLIP-seq
MIRT892613	hsa-miR-3619-5p	CLIP-seq
MIRT892614	hsa-miR-363	CLIP-seq
MIRT2503426	hsa-miR-3654	CLIP-seq
MIRT892615	hsa-miR-367	CLIP-seq
MIRT2678199	hsa-miR-370	CLIP-seq
MIRT2503427	hsa-miR-4261	CLIP-seq
MIRT892619	hsa-miR-4291	CLIP-seq
MIRT2678200	hsa-miR-433	CLIP-seq
MIRT2503428	hsa-miR-4528	CLIP-seq
MIRT2503429	hsa-miR-668	CLIP-seq
MIRT892629	hsa-miR-761	CLIP-seq
MIRT892630	hsa-miR-767-3p	CLIP-seq
MIRT2503430	hsa-miR-875-3p	CLIP-seq
MIRT892631	hsa-miR-922	CLIP-seq
MIRT892632	hsa-miR-92a	CLIP-seq
MIRT892633	hsa-miR-92b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001517	Function	N-acetylglucosamine 6-O-sulfotransferase activity	IBA
GO:0001517	Function	N-acetylglucosamine 6-O-sulfotransferase activity	IDA	10913333
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005976	Process	Polysaccharide metabolic process	TAS	10781596
GO:0006044	Process	N-acetylglucosamine metabolic process	IBA
GO:0006044	Process	N-acetylglucosamine metabolic process	IDA	10913333
GO:0006790	Process	Sulfur compound metabolic process	IDA	10913333
GO:0006790	Process	Sulfur compound metabolic process	IEA
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008459	Function	Chondroitin 6-sulfotransferase activity	IBA
GO:0008459	Function	Chondroitin 6-sulfotransferase activity	IDA	10781596
GO:0008459	Function	Chondroitin 6-sulfotransferase activity	IEA
GO:0008459	Function	Chondroitin 6-sulfotransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10913333
GO:0016020	Component	Membrane	TAS	10781596
GO:0016740	Function	Transferase activity	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IDA	10781596
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	TAS

MIM	HGNC	e!Ensembl
300375	13817	ENSG00000147119

Q9NS84

Protein name

Carbohydrate sulfotransferase 7 (EC 2.8.2.-) (EC 2.8.2.17) (Chondroitin 6-sulfotransferase 2) (C6ST-2) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5) (GST-5) (N-acetylglucosamine 6-O-sulfotransferase 4) (GlcNAc6ST-4) (Gn6st-4)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	101 → 458	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin. {ECO:0000269|PubMed:10781596, ECO:000

Sequence

MKGRRRRRREYCKFALLLVLYTLVLLLVPSVLDGGRDGDKGAEHCPGLQRSLGVWSLEAA
AAGEREQGAEARAAEEGGANQSPRFPSNLSGAVGEAVSREKQHIYVHATWRTGSSFLGEL
FNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFRCDFSVLRLYAPPGDPAAR
APDTANLTTAALFRWRTNKVICSPPLCPGAPRARAEVGLVEDTACERSCPPVAIRALEAE
CRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRQGLLRESIQ
VLRTRQRGDRFHRVLLAHGVGARPGGQSRALPAAPRADFFLTGALEVICEAWLRDLLFAR
GAPAWLRRRYLRLRYEDLVRQPRAQLRRLLRFSGLRALAALDAFALNMTRGAAYGADRPF
HLSARDAREAVHAWRERLSREQVRQVEAACAPAMRLLAYPRSGEEGDAEQPREGETPLEM
DADGAT

Sequence length

486

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	Chondroitin sulfate biosynthesis

CHST7 (carbohydrate sulfotransferase 7)

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